Abstract: A microfluidic system for the validation and study of nanomaterials, drugs, or mixtures thereof for biomedical and/or pharmaceutic applications includes a device for the production of an organoid cell culture having: a base layer for support; a transducer layer arranged on the base layer; and an intermediate layer, arranged on the transducer layer. The intermediate layer has a plurality of cavities for organoid cell growth and a microchannel network for fluid flow, a heating device, and at least a plurality of sensors in each cavity for cell parameter control and growth. Each sensor is located for measuring an organoid cell growth parameter in the interior of each cavity. The heating device is located in the interior of each cavity. The heating device and the plurality of sensors are in direct contact with the organoid cell culture. The plurality of sensors is selected from temperature sensor, pH sensor, heaters or combinations thereof.