Abstract: Bcl-2 inhibitors, pharmaceutical compositions thereof, and methods of use thereof are provided. In particular, Bcl-2 inhibitors of formula (I) are provided, wherein the variable groups are as defined in the specification. The Bcl-2 inhibitors can be used to treat cell proliferative disorders.

Abstract: The present application provides a piezoelectric microphone including a substrate having a back cavity and a piezoelectric cantilever diaphragm fixed to the substrate, the piezoelectric cantilever diaphragm includes a fixed end fixedly connected to the substrate and a movable end connected to the fixed end and suspended above the back cavity, the piezoelectric microphone further includes a support back plate, the support back plate includes a support arm opposite to and spaced apart from the movable end of the piezoelectric cantilever diaphragm and a fixing arm that fixes the support arm. The piezoelectric microphone of the present disclosure has better stability compared to the related art.

Abstract: An actuator device includes: an actuator including first contacts arranged in a first direction; and a wire member including second contacts and joined to the actuator. The second contacts are arranged in the first direction and respectively connected to the first contacts. Each of particular contacts as the first contacts or the second contacts has a protruding and recessed portion including: at least two protrusions; and a recess between the at least two protrusions. The particular contacts include: at least one central-region contact disposed on a central region in the first direction; and at least one end-region contact disposed nearer to an end region than to the central region in the first direction. The protruding and recessed portion of each of the at least one central-region contact is different in shape from the protruding and recessed portion of each of the at least one end-region contact.

Abstract: Facilitating localization of code defect of an application includes receiving a set of element-value pairs generated by running the application with a test case. Further differences are identified between the set of element-value pairs and a baseline data result for the test case. Tree maps associated with respective elements are displayed in the set of element-value pairs, each of the tree maps representing relationship of code entities of the application related to its associated element, wherein one or more of the tree maps are marked out to show the differences thereby identifying potential defective codes of the application that have caused the differences.

Abstract: A dispenser for sheet products includes a housing having a space inside for accommodating a stack of sheet products, wherein the housing includes a dispensing opening for dispensing a sheet product from the front of the stack, an electronic controller configured to receive a pull-out signal indicating the removal of a product from the front of the stack through the dispensing opening and, upon receiving said pull-out signal, to send out a drive signal to transfer a number of sheet products from the front of the stack into a presentation position, and a pull-out detector for detecting the removal of a product from the front of the stack through the dispensing opening and for providing the pull-out signal to the controller.

Abstract: Disclosed is a railway hopper car comprising a car body (6), a top cover (1, 2), a bogie (24), a braking device (21), a coupler buffer device (22), and a bottom door (25, 28) and a bottom door opening and closing mechanism (23) mounted at a discharge port at the bottom of a chassis. The railway hopper car further comprises a longitudinal saddle (31) disposed in the center of the car body (6) in the length direction thereof and arranged along the longitudinal direction of the car body (6). By providing the longitudinal saddle (31), the sequential requirement to close the left bottom door (25) and the right bottom door (28) is eliminated, thereby simplifying the structure of the linkage bottom door opening and closing mechanism and reducing manufacture and maintenance costs thereof.

Abstract: The present invention provides the use of Cimicifugae rhizoma triterpenoid saponin extract, Cimicifugae rhizoma, actein, deoxyactein, or a composition formed by actein and deoxyactein in the preparation of a medicament or a functional health product for autoimmune diseases. The present invention also provides a pharmaceutical composition for autoimmune diseases and a pharmaceutical composition for inhibiting inflammatory cytokines. The invention provides new applications of Cimicifugae rhizoma triterpenoid saponin extract, Cimicifugae rhizoma, actein, deoxyactein, etc., and widens the application field of medicines or functional health products for autoimmune diseases. The raw materials source is plenty, the cost is low, and it has a broad market application value.

Abstract: An approach is provided for generating a scaling plan. Plans for onboarding first tenant(s) a cloud computing environment and offboarding second tenant(s) of the cloud computing environment are received. Historical data about behavior of tenants of the cloud computing environment is received. Based on the received plans and the historical data, a scaling plan for scaling computer resources of external systems during the onboarding and the offboarding is generated. The scaling plan specifies a timeline indicating dates and times at which changes in workloads associated with the external systems are required for the onboarding and the offboarding. Based on the scaling plan, a scaling is determined to be needed for computer resource(s) of one of the external systems. Responsive to determining that the scaling is needed, the scaling for the computer resource(s) is triggered at a date and a time indicated by the timeline.

Abstract: An advanced map matching algorithm is disclosed, which embeds the road topology inherently in a set of path candidates. Road connectivity is maintained even in special situations such as U-turns, reverse driving, and tunnels. Careful path candidate management is designed to reduce the candidate count while preserving well-matching candidates. Paths are treated and evaluated independently using multiple criteria, which makes the algorithm reliable and robust in different scenarios.

Abstract: Systems and methods are disclosed which provide for a “factory-calibrated” sensor. In doing so, the systems and methods include predictive prospective modeling of sensor behavior, and also include predictive modeling of physiology. With these two correction factors, a consistent determination of sensitivity can be achieved, thus achieving factory calibration.

Abstract: A feature fusion and dense connection-based method for infrared plane object detection includes: constructing an infrared image dataset containing an object to be recognized, calibrating a position and class of the object to be recognized in the infrared image dataset, and obtaining an original known label image; dividing the infrared image dataset into a training set and a validation set; performing image enhancement preprocessing on images in the training set, performing feature extraction and feature fusion, and obtaining classification results and bounding boxes through a regression network; calculating a loss function according to the classification results and the bounding boxes in combination with the original known label image, and updating parameter values of a convolutional neural network; repeating the steps to iteratively update the parameters of the convolutional neural network; and processing images in the validation set through the parameters to obtain a final object detection result map.

Abstract: Embodiments of the present disclosure relate to methods and network nodes and user equipment for measurement reporting. In example embodiments, a method implemented in a user equipment is provided. According to the method, the user equipment detects a plurality of beams from one or more of the UE's neighboring nodes, forms one measurement result of a group based on beam grouping information, and then send measurement report to the UE's serving node, including the measurement result of the group is included in the measurement report. According to the present disclosure, more neighboring nodes can be reported by the UE in a measurement report.

Abstract: There is provided an aerosol-generating system including an aerosol-generating device and an aerosol-forming cartridge including at least one aerosol-forming substrate, wherein in use the aerosol-forming cartridge is at least partially received within the aerosol-generating device. The system further includes at least one electric heater configured to heat the at least one aerosol-forming substrate, at least one air inlet, and at least one air outlet. The system further includes an air flow channel extending between the at least one air inlet and the at least one air outlet. The air flow channel is in fluid communication with the aerosol-forming substrate, and has an internal wall surface on which one or more flow disturbing devices are disposed, the flow disturbing devices being arranged to create a turbulent boundary layer in a flow of air drawn through the air flow channel.

Abstract: An injection molding apparatus comprising a clamp plate, a heated manifold, an actuator, a mold and a cooling device, wherein the cooling device comprises: a heat transmitter comprising a distal arm or member and a proximal base or member, the distal arm or member being mounted by a spring loadable interconnection or engagement to or with the proximal base or member, the clamp plate, the mold, the manifold, the actuator and the heat transmitter being assemblable together in an arrangement wherein the spring loadable interconnection is loaded urging the distal end surface of the distal arm or member into compressed engagement with the clamp plate.

Abstract: The present disclosure provides a robot mapping method as well as a robot and a computer readable storage medium using the same. The method includes: detecting a marker with identification information capable of being identified by the robot in a current scene; determining whether the detected marker meets a preset condition; and mapping the current scene based on the marker, if the detected marker meets the preset condition. The robot mapping method can not only map the current scene, but also effectively reduce the difficulty of loops and the number of false loops.

Abstract: The present disclosure provides a device and method for depth sensing by utilizing the combination of a ranging sensor and an image sensor. The ranging sensor can accurately detect distance measurement from an object. The image sensor can take images with high resolution of the object. By combining each sensor data from the ranging sensor and the image sensor, accurate depth information with high resolution of the object may be obtained. A structured light having patterned shapes are used in conjunction with the ranging sensor to receive reflected patterned shapes of the object. These reflected patterned shapes are used to analyze distance measurements associated with the specific patterned shapes. These distance measurements from both the ranging sensor and the image sensor is aligned and combined to generate an accurate depth map with high resolution using a processor of an electronic device including the ranging sensor and the image sensor.

Abstract: The present disclosure provides advantageous interference anchor. More particularly, an advantageous tendon interference anchor configured to be inserted through impaction. The tendon interference anchor may include an anchor body having a proximal end, distal end, longitudinal axis, and an outer surface and at least one protrusion extending outwardly from the outer surface of the anchor body in a direction non-parallel to the longitudinal axis of the anchor body.

Abstract: The present disclosure relates to a display substrate, a method for driving the same, and a display panel. The display substrate includes a base substrate as well as gate lines, data lines and a gate driver on the base substrate, the gate line being connected to the gate driver, and electrostatic rings and control components corresponding to at least one gate line are further disposed on the base substrate, each of the gate lines being connected to the electrostatic ring by a corresponding control component. The electrostatic ring is configured to load a control voltage to turn on the corresponding control component after the display panel is turned off, and the corresponding control component is configured to be turned on to change a voltage on the gate line into a turn-on voltage after the display panel is turned off.

Abstract: Embodiments described herein provide a gas supply system for reducing purge time and increasing processing throughput, and an atomic layer deposition (ALD) chamber having the same. The gas supply system includes an inert gas line and a precursor supply line. The inert gas line is configured to be coupled to an inlet of the chamber separate from the precursor supply line. Therefore, the inert gas is supplied concurrently to the precursor supply line and the processing region of the chamber such that total purge time is reduced. The reduction of the total purge time due to the gas supply system increases purge efficiency and increases processing throughput. Furthermore, the gas supply system allows inert gas to be utilized as a dilution gas during flow of precursors.

Abstract: In some examples, a networked computing system comprises a backup node cluster of a backup service in communication with a host database node cluster of a host, a host database at least initially undiscovered by the backup node cluster, one or more processors coupled with memory storing instructions that, when executed, perform operations comprising at least installing a backup agent on at least one node of the host database node cluster, registering the host at the backup service, based on the host registration, triggering a host database discovery process to discover the undiscovered database automatically, the discovery process including a discovery call, in response to the discovery call, receiving metadata relating to the discovered database, and communicating with the discovered database.