Abstract: Provided herein are GLP-1 receptor modulator compounds, pharmaceutical compositions, methods of their preparation, and methods of their use in treatment, and/or diagnosis.

Abstract: Onboard a machine adapted to move on one predetermined path, a database stores definition data of landmark objects along the path and associated to its 3D geographical coordinates and a capture block provides images of the scene in front of the machine. The capture block includes a teledetection block adapted to create an image from received echos and to calculate from the echoes, direction and distance, relative to the machine, of the echoing object.

Abstract: The present disclosure relates to novel intermediates, preparation process thereof, and a process for producing isofetamid. The present disclosure also relates to the use of novel intermediates for preparing isofetamid. The present disclosure further relates to a process for preparation of some other intermediates of isofetamid using the novel intermediates.

Abstract: A flip-to-side mount of the present disclosure includes a main shaft arranged in a left-right direction; a first frame body sleeved on the main shaft which is adapted to move left and right relative to the first frame body and to rotate synchronously with the first frame body; a second frame body rotatably arranged on an end of the main shaft, an end of the second frame body being provided with a plurality of clamping grooves along a circumferential direction; a first pin arranged on the main shaft and accommodated in corresponding ones of the clamping grooves, rotation of the second frame body driving the first pin to move towards right and out of the corresponding ones; and an elastic member adapted to drive the main shaft to move towards the first frame body. The present disclosure also provides a magnifier optic.

Abstract: The present disclosure provides multi-specific molecules specific for SIPR-alpha and one or more target antigens, isolated polynucleotide encoding the same, pharmaceutical compositions comprising the same, and the uses thereof. The present disclosure provides the multi-specific molecule provided comprises a SIRP-alpha binding domain, an activating receptor-binding domain comprising an Fc domain, and a target antigen binding domain.

Abstract: Provided are anti-CLDN18 (in particular, anti-CLDN18.2) antibodies or antigen-binding fragments thereof, isolated polynucleotides encoding the same, pharmaceutical composition comprising the same and the uses thereof.

Abstract: Provided herein are GLP-1 receptor modulator compounds, pharmaceutical compositions, methods of their preparation, and methods of their use in treatment, and/or diagnosis.

Abstract: A power distribution control approach employs power distribution buses that are controllably energized and de-energized to control which aerial vehicle systems received power based on the applicable operational mode. A method of controlling power distribution in an electrically powered vertical takeoff and landing aircraft includes receiving an operational mode indication that identifies an operational mode. The operational mode is one of predetermined operational modes for the aircraft. Power distribution buses of the aircraft are controlled, based on the operational mode indication, to control each of the power distribution buses to be energized or de-energized.

Abstract: A special-shaped thin-film transistor and an array substrate are provided. The special-shaped thin-film transistor includes a first gate portion, a first compensation electrode, and a first source electrode. The first compensation electrode is connected to the first gate portion. The first source electrode includes a first extension part, a first source portion, and a second extension part which are connected in sequence. Part of the first extension part overlaps the first gate portion, and part of the second extension part overlaps the first compensation electrode.

Abstract: Power distribution systems, battery packs, and batteries employ battery modules that are connected in series to generate a high-voltage output and in parallel to generate a low-voltage output. A battery includes battery modules and a direct current to direct current converter. The battery modules are electrically connected in series to generate a first battery high-voltage output. The battery modules are electrically connected in parallel to generate a battery modules low-voltage output. The direct current to direct current converter generates a battery low-voltage output from the battery modules low-voltage output.

Abstract: A thermoplastic composition comprising: 45-90 wt % of a polycarbonate; 5-15 wt % of a brominated polycarbonate; a polycarbonate-siloxane copolymer in an amount effective to provide 0.2-2 wt % siloxane based on the total weight of the thermoplastic composition; 2-10 wt % of a silicone-containing impact modifier comprising a core-shell impact modifier; 0.1-1 wt % of a flame retardant comprising an alkyl sulfonate salt, aromatic sulfone sulfonate, an aromatic sulfonate salt, or a combination thereof; optionally, 0.5-10 wt % titanium dioxide; optionally, 0.1-1 wt % carbon black, wherein the wt % of each component is based on the total weight of the composition, which totals 100 wt %.

Abstract: A system may include a memory and a processor in communication with the memory. The processor may be configured to perform operations. The operations may include synchronizing a policy between a primary node and a compute node and maintaining a resource registry on a client of the primary node. The operations may include communicating a direct communication between the client and the compute node, and the direct communication may include a first task. The operations may include returning a first result for the first task directly from the compute node to the client.

Abstract: A thermoplastic polycarbonate composition comprising: 5 to 28 wt % of a brominated polycarbonate; 45 to 90 wt % of a homopolycarbonate having a weight average molecular weight from 20,000-25,000 grams/mole as measured via gel permeation chromathography using bisphenol A homopolycarbonate standards; 0 to 15 wt % of an aromatic poly(ester-carbonate) comprising carbonate units derived from bisphenol A, resorcinol, or a combination thereof, and ester units derived from a bisphenol, preferably bisphenol A, or resorcinol, and terephthalic acid, isoterephthalic acid, or a combination thereof, wherein a molar ratio of carbonate units to ester units ranges from 1:99 to 99:1; 2 to 10 wt % of a core-shell impact modifier; 1 to 7 wt % of an ?,?-unsaturated glycidyl ester copolymer impact modifier; 0.6 to 3.5 wt % color composition comprising titanium dioxide and carbon black; wherein the wt % of each component is based on the total weight of the composition, which totals 100 wt %.

Abstract: Provided are conjugate molecules comprising a CD39 inhibitory portion capable of interfering interaction between CD39 and its substrate, and a TGF ? inhibitory portion capable of interfering interaction between TGF ? and its receptor, isolated polynucleotides encoding the same, pharmaceutical compositions comprising the same and the uses thereof.

Abstract: To reduce crosstalk between bond wires, one illustrative integrated circuit includes an array of photoemitters arranged along a centerline, with adjacent photoemitters having contact pads on opposite sides of the centerline. An illustrative assembly includes an integrated circuit chip having an array of photoemitter contact pads; a printed circuit board having a recess in which the integrated circuit chip is mounted; and bond wires connecting the contact pads with respective contact pads on the printed circuit board. An illustrative cable connector includes a module that optically couples optical fibers to an array of photoemitters on an integrated circuit chip mounted to a printed circuit board. Each photoemitter has contact pads connected to the printed circuit board contact pads by bond wires, the bond wires for each photoemitter being routed in an opposite direction relative to the bond wires for any adjacent photoemitters in the array.

Abstract: Provided are a video clipping and model training method, relating to the field of video technologies, and in particular, to the field of short video technologies. The video clipping method includes: acquiring interaction behavior data for an original video file; determining interaction heat at respective time points of the original video file, according to the interaction behavior data; selecting N time points with highest interaction heat, to take the selected time points as interest points of the original video file, where N is a positive integer; and clipping the original video file based on the respective interest points, to obtain N clipped video files. Therefore, high-quality short video files can be generated.

Abstract: Provided are a video title generation method, an electronic device and a storage medium, which relate to a technical field of video, and in particular to a technical field of short video. The method includes: obtaining a plurality of pieces of optional text information, for a first video file; determining central text information, from the plurality of pieces of optional text information, the central text information being optional text information with the highest similarity to content of the first video file; and determining the central text information as a title of the first video file. That is, an interest point in an original video file can be determined according to user's interactive behavior data on the original video file, and the original video file can be clipped based on the interest point to obtain a plurality of clipped video files, namely, short videos.

Abstract: The invention relates to a preparation method of (4-isopropoxy-2-methyl)phenyl isopropyl ketone, particularly the preparation method includes: reacting m-cresol with thiocyanate in the presence of a catalyst to obtain a product A; reacting the product A with haloisopropane in the presence of a base and a catalyst to obtain a product B; reacting the product B with isopropyl magnesium halide and treating to obtain (4-isopropoxy-2-methyl)phenyl isopropyl ketone. The purity of (4-isopropoxy-2-methyl)phenyl isopropyl ketone prepared is more than 99%, and the total yield is more than 79%. The method according to the present invention avoids the use of toxic reagents and the generation of a large amount of acidic wastewater, reduces the reaction temperature, and improves the reaction yield. The process route is simple and efficient, and the cost is reduced. The purity of the resulting product is high, the production security is greatly improved, and the method is easy to industrialize.