Abstract: This invention refers to photo-crosslinked hydrogel materials based in gellan gum suitable for tissue engineering and regenerative medicine applications or as drug delivery systems. Formulations of gellan gum with different degrees of acylation serve as precursor material for insertion of a polymerizable moiety. The materials are capable of free radical polymerization with a photo-initiator at mild temperatures and exposure to ultraviolet light, enabling control of reticulation and withstanding the encapsulation of human and animal cells and/or drugs, and any combination thereof. The physicochemical and biological properties can be adjusted by combining different formulations of gellan gum and reaction conditions.

Abstract: Friedelin is a natural compound with promising proprieties. On its own or with chemical modification it is possible to introduce relevant biological activities, e.g., anti-cancer, anti-aging and agrochemical. Its availability in significant amounts has been a major drawback on its regular use and in the pursuit of different applications. Cork and cork-derived materials (e.g., black condensate) are the most relevant sources of Friedelin in nature (up to 10% in concentration). The present invention reports straight-forward procedures to extract and purify Friedelin from cork and cork-derived materials (e.g., black condensate). It uses solvent extraction and (re)crystallization techniques easy to scale up to an industrial level, with a low solvent and low time consumption, high yields, up to 2.9%, and high purity degrees, up to 96%.

Abstract: The invention relates to a device for tissue engineering a bone equivalent comprising a scaffold material, which scaffold material comprises a matrix based on a destructured, natural, starch-based polymer. The invention further relates to a process for tissue engineering said bone equivalent, a hybrid structure obtainable by said process, and to the use of said hybrid structure in various surgical treatments.

Abstract: The invention relates to a device for tissue engineering a bone equivalent comprising a scaffold material, which scaffold material comprises a matrix based on a destructured, natural, starch-based polymer. The invention further relates to a process for tissue engineering said bone equivalent, a hybrid structure obtainable by said process, and to the use of said hybrid structure in various surgical treatments.

Abstract: The invention relates to a device for tissue engineering a bone equivalent comprising a scaffold material, which scaffold material comprises a matrix based on a destructured, natural, starch-based polymer. The invention further relates to a process for tissue engineering said bone equivalent, a hybrid structure obtainable by said process, and to the use of said hybrid structure in various surgical treatments.