Abstract: This disclosure provides methods, devices, and systems for controlling motion-activated switches. The present implementations more specifically relate to relay controller that prevent motion-activated switches from turning off devices associated with an environment in which people are present. In some aspects, a motion-activated switch may include a relay controller coupled to a motion sensor, a camera, and a relay. The motion sensor outputs a motion trigger to the relay controller responsive to detecting motion in an environment. The motion trigger may cause the relay controller to acquire one or more images of the environment, via the camera, and selectively toggle the relay based on the acquired images. For example, the relay controller may close the relay responsive to identifying an image that includes an object of interest or may open the relay controller may open the relay responsive to identifying an image that does not include an object of interest.

Abstract: A device configured to determine the location and magnitude of a touch on a surface of the device. The device includes a transparent touch sensor that is configured to detect a location of a touch on the transparent touch sensor. The device also includes a force-sensing structure disposed at the periphery of the transparent touch sensor. The force sensor includes an upper capacitive plate and a compressible element disposed on one side of the upper capacitive plate. The force sensor also includes a lower capacitive plate disposed on a side of the compressible element that is opposite the upper capacitive plate.

Abstract: This disclosure provides methods, devices, and systems for controlling motion-activated switches. The present implementations more specifically relate to relay controller that prevent motion-activated switches from turning off devices associated with an environment in which people are present. In some aspects, a motion-activated switch may include a relay controller coupled to a motion sensor, a camera, and a relay. The motion sensor outputs a motion trigger to the relay controller responsive to detecting motion in an environment. The motion trigger may cause the relay controller to acquire one or more images of the environment, via the camera, and selectively toggle the relay based on the acquired images. For example, the relay controller may close the relay responsive to identifying an image that includes an object of interest or may open the relay controller may open the relay responsive to identifying an image that does not include an object of interest.

Abstract: The present systems and methods introduce deep learning to de novo peptide sequencing from tandem mass spectrometry data, and in particular mass spectrometry data obtained by data-independent acquisition. The systems and methods achieve improvements in sequencing accuracy over existing systems and methods and enables complete assembly of novel protein sequences without assisting databases. To sequence peptides from mass spectrometry data obtained by data-independent acquisition, precursor profiles representing intensities of one or more precursor ion signals associated with a precursor retention time and fragment ion spectra representing signals from fragment ions and fragment retention times are fed into a neural network.

Abstract: The present systems and methods are directed to de novo identification of peptide sequences from tandem mass spectrometry data. The systems and methods uses unconverted mass spectrometry data from which features are extracted. Using unconverted mass spectrometry data reduces the loss of information and provides more accurate sequencing of peptides. The systems and methods combine deep learning and neural networks to sequencing of peptides.

Abstract: The present disclosure generally relate s to blood pressure monitoring. In some embodiments, methods and devices for measuring a mean arterial pressure and/or for monitoring blood pressure changes of a user are provided. Blood pressure measured by one or more pressure sensors may be adjusted using one or more correction factors. The use of the one or more correction factors disclosed herein may allow for more compact, convenient, and/or accurate wearable blood pressure measurement devices and methods. In particular, wrist-worn devices may be provided which are less bulky than current devices and may facilitate more frequent and accurate blood pressure monitoring.

Abstract: The present disclosure generally relate s to blood pressure monitoring. In some embodiments, methods and devices for measuring a mean arterial pressure and/or for monitoring blood pressure changes of a user are provided. Blood pressure measured by one or more pressure sensors may be adjusted using one or more correction factors. The use of the one or more correction factors disclosed herein may allow for more compact, convenient, and/or accurate wearable blood pressure measurement devices and methods. In particular, wrist-worn devices may be provided which are less bulky than current devices and may facilitate more frequent and accurate blood pressure monitoring.

Abstract: The present systems and methods are directed to de novo identification of peptide sequences from tandem mass spectrometry data. The systems and methods uses unconverted mass spectrometry data from which features are extracted. Using unconverted mass spectrometry data reduces the loss of information and provides more accurate sequencing of peptides. The systems and methods combine deep learning and neural networks to sequencing of peptides.

Abstract: A method of thermally insulating a surface, the method comprising applying a coating of a thermally insulating composition onto said surface, wherein said thermally insulating composition comprises: (i) hollow spherical nanoparticles having a mean particle size of less than 800 nm in diameter and a particle size distribution in which at least 90% of the hollow spherical nanoparticles have a size within ±20% of said mean particle size, and a first layer of cationic or anionic molecules attached to said surfaces of the hollow spherical nanoparticles; and (ii) a second layer of molecules of opposite charge to the first layer of molecules, wherein said second layer of molecules of opposite charge are ionically associated with said first layer of molecules, wherein the molecules in said second layer have at least eight carbon atoms.

Abstract: The present systems and workflows identify neoantigens for cancer immunotherapy by introducing deep learning to de novo peptide sequencing from tandem mass spectrometry data. The systems and workflow allows for patient specific identification of neoantigens for personalized immunotherapy.

Abstract: A device configured to determine the location and magnitude of a touch on a surface of the device. The device includes a transparent touch sensor that is configured to detect a location of a touch on the transparent touch sensor. The device also includes a force-sensing structure disposed at the periphery of the transparent touch sensor. The force sensor includes an upper capacitive plate and a compressible element disposed on one side of the upper capacitive plate. The force sensor also includes a lower capacitive plate disposed on a side of the compressible element that is opposite the upper capacitive plate.

Abstract: A device configured to determine the location and magnitude of a touch on a surface of the device. The device includes a transparent touch sensor that is configured to detect a location of a touch on the transparent touch sensor. The device also includes a force-sensing structure disposed at the periphery of the transparent touch sensor. The force sensor includes an upper capacitive plate and a compressible element disposed on one side of the upper capacitive plate. The force sensor also includes a lower capacitive plate disposed on a side of the compressible element that is opposite the upper capacitive plate.

Abstract: The present systems and methods introduce deep learning to de novo peptide sequencing from tandem mass spectrometry data, and in particular mass spectrometry data obtained by data-independent acquisition. The systems and methods achieve improvements in sequencing accuracy over existing systems and methods and enables complete assembly of novel protein sequences without assisting databases. To sequence peptides from mass spectrometry data obtained by data-independent acquisition, precursor profiles representing intensities of one or more precursor ion signals associated with a precursor retention time and fragment ion spectra representing signals from fragment ions and fragment retention times are fed into a neural network.

Abstract: A method of thermally insulating a surface, the method comprising applying a coating of a thermally insulating composition onto said surface, wherein said thermally insulating composition comprises: (i) hollow spherical nanoparticles having a mean particle size of less than 800 nm in diameter and a particle size distribution in which at least 90% of the hollow spherical nanoparticles have a size within ±20% of said mean particle size, and a first layer of cationic or anionic molecules attached to said surfaces of the hollow spherical nanoparticles; and (ii) a second layer of molecules of opposite charge to the first layer of molecules, wherein said second layer of molecules of opposite charge are ionically associated with said first layer of molecules, wherein the molecules in said second layer have at least eight carbon atoms.

Abstract: A sensor layer, such as a force sensor layer, can be in included in an electronic device. The sensor layer includes a patterned compliant layer that is positioned between a first substrate and a second substrate. The patterned compliant layer includes multiple angled compliant elements that are angled at one or more angles with respect to the first and second substrates.

Abstract: An electronic device having a housing that defines an interior volume, the housing being suitable for carrying at least a processor within the internal volume, the housing comprising an edge that defines an opening that provides access to the internal volume. The electronic device can have a cover carried at the edge of the housing and within the opening and having an external surface capable of receiving an external force and a sealing element disposed between the housing and the cover, with the sealing element preventing intrusion of liquid into the internal volume. The sealing element can include a sealing material and a sensor contained within the sealing material that senses that an external force is applied to the external surface of the cover and, in response, provides a signal to the processor.

Abstract: A sensor includes a patterned compliant layer positioned between two substrates. Each substrate can include one or more conductive electrodes, with each electrode of one substrate paired with a respective electrode of the other substrate. Each pair of conductive electrodes forms a capacitor. Several methods are disclosed that can be used to produce the patterned compliant layer.

Abstract: A sensor layer, such as a force sensor layer, can be in included in an electronic device. The sensor layer includes a patterned compliant layer that is positioned between a first substrate and a second substrate. The patterned compliant layer includes multiple angled compliant elements that are angled at one or more angles with respect to the first and second substrates.

Abstract: A sensor includes a patterned compliant layer positioned between two substrates. Each substrate can include one or more conductive electrodes, with each electrode of one substrate paired with a respective electrode of the other substrate. Each pair of conductive electrodes forms a capacitor. Several methods are disclosed that can be used to produce the patterned compliant layer.

Abstract: A device configured to determine the location and magnitude of a touch on a surface of the device. The device includes a transparent touch sensor that is configured to detect a location of a touch on the transparent touch sensor. The device also includes a force-sensing structure disposed at the periphery of the transparent touch sensor. The force sensor includes an upper capacitive plate and a compressible element disposed on one side of the upper capacitive plate. The force sensor also includes a lower capacitive plate disposed on a side of the compressible element that is opposite the upper capacitive plate.