Abstract: Provided herein are compounds of formula (I) and (II), or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a G12D mutation) and treating diseases or disorders such as cancers in subjects in need thereof.

Abstract: An aluminum alloy flux-cored welding wire and a fabrication method thereof are provided. In the present disclosure, a mixed salt is used as a filler for the flux-cored welding wire, and a reaction between the mixed salt and a welding base metal is directly induced through welding heat to produce in situ nanoparticles, which not only reduces a production cost of the welding wire, but also enhances the bonding between the added particles and the base metal through the prominent wettability between the in-situ enhancement particles and the base metal; and a rare earth element is added to significantly refine grains, which provides a new idea for the selection of a flux-cored welding wire for 7XXX aluminum alloy welding.

Abstract: A prestressed fish-belly reaction frame, a pile foundation bearing capacity detection device and application thereof, which includes: a core junction; a reaction beam including a plurality of beam units symmetrically arranged around the core junction with the core junction as a center, each beam unit has a first end and a second end, the first end is connected and fixed to the core junction, and the second end is connected and fixed to a pile top of an anchor pile when the pile foundation bearing capacity is detected; a prestressed assembly including a plurality of prestressed tendons, each prestressed tendon passes through an upper end of the core junction, a first end of each prestressed tendon is connected and fixed to the second end of one beam unit, a second end thereof is connected and fixed to the second end of the symmetrical beam unit.

Abstract: The present disclosure relates to a method for determining a target spot path, which is applied to a determining system including a shooting device and a locating device that are separate from each other, and a calibration device connected to the shooting device, the method comprising: S1. obtaining a three-dimensional partial image for an affected part and a virtual path located in the three-dimensional partial image; S2. matching a simulated two-dimensional image obtained based on projection of the three-dimensional partial image with a two-dimensional projection image obtained based on the affected part; S3. determining a surgical guide path on the two-dimensional projection image that corresponds to the virtual path according to position information of the virtual path on the simulated two-dimensional image, when the simulated two-dimensional image and the two-dimensional projection image are matched; and/or S4.

Abstract: The present invention relates to a curable binder composition comprising: a) at least one organic binder comprising a polyisocyanate and a polyol, and b) at least 50% by weight of a filler in the form of quartz and/or slag, based on 100% by weight of binder composition.

Abstract: A system includes a functional unit having a processor and address management circuitry. The address management circuitry is to receive a request from the processor, where the request is associated with a boot process initialized at the processor. The address management circuitry is to determine a bit stored at the address management circuitry has a first value indicating to associate the request with a first node identifier associated with a memory region storing data associated with the boot process instead of a second node identifier associated with nodes storing physical locations associated with a memory address of the request. The address management circuitry can further transmit the request with the first node identifier to logic at a first node coupled to the memory region responsive to determining the bit has the first value.

Abstract: An integrated circuit includes a set of functional units having at least a first functional unit and a second functional unit. The first functional unit includes first processing circuitry and a first circuit coupled to the first processing circuitry to receive a message from the second functional unit of the set of functional units. The first circuit is further to delay the message for the first processing circuitry for a predetermined duration, where the predetermined duration is based in part on a first value representing a first distance between the first functional unit and the second functional unit and a second value representing a second distance between the second functional unit and a functional unit of the set of functional units that is farthest away from the second functional unit.

Abstract: An impact tool includes a controller for controlling a motor. The controller is configured to, when the direction of rotation of the motor is set to the reverse rotation direction, a drive shaft rotates at a first speed, and after an impact mechanism applies an impact force to an output shaft for a preset time, determine that a fastener is in a tightened state according to a load parameter of the output shaft and control the drive shaft to rotate at a second speed, where the second speed is greater than the first speed.

Abstract: A five-membered-fused six-membered compound, and a preparation method therefor and a pharmaceutical composition and the use thereof. The five- and six-membered compound is a compound as shown in formula I, II or III. The compound has an inhibitory effect on FLT3 and/or IRAK4.

Abstract: A data transmission method and an apparatus are provided. In the method, a terminal receives configured grant (CG) information from a network device; obtains a configured quantity N of transport blocks (TBs) in a CG periodicity based on the CG information, where the configured quantity N of TBs is a maximum quantity of TBs transmittable in the CG periodicity, and N is an integer greater than 0; and sends, to the network device in the CG periodicity, uplink data corresponding to M TB, where Mis an integer greater than 0 and less than or equal to N. According to the method, complete transmission of an extended reality (XR) video frame can be completed in the CG periodicity, thereby improving user experience of receiving an XR service.

Abstract: A data transmission method and a communication apparatus are provided. The method includes: A network device sends first information to a terminal. The terminal receives the first information, and determines an evaluation mode of user experience based on the first information. The terminal sends second information to the network device. The network device receives the second information, and communicates with the terminal based on the second information. The first information is used to configure the evaluation mode of user experience, the evaluation mode of user experience is one of a plurality of evaluation modes of user experience, the evaluation mode of user experience is used to evaluate impact of network transmission on user experience, and the second information includes information about the impact of the network transmission on user experience.

Abstract: A resource configuration method and a communication apparatus are provided, so that an SPS/CG period can better match an XR service that arrives periodically based on a frame rate, thereby effectively reducing a transmission delay of the XR service and improving system performance. The method includes the following steps: a network device sends first CG configuration information to a terminal. Correspondingly, the terminal receives the configuration information, and obtains first period duration M1 of a first CG period and a quantity X of CGs in the first CG period based on the information, where M1 is greater than zero, and X is an integer greater than zero.

Abstract: Systems, methods, and computer program products can be used for determining the amount of oil removed by a miscible gas flood. One of the methods includes identifying locations of oil within a volume representing a reservoir rock sample. The method includes identifying locations of gas within the volume. The method also includes determining the amount of oil removed based on locations within the volume where oil is either coincident with the gas or is connected to the gas by a continuous oil path.

Abstract: Disclosed are a functional material for synchronously stabilizing multiple metals and a preparation method thereof, and a method for rehabilitating soil or wastewater contaminated by heavy metals (metalloids). The preparation method includes: mixing a ferrous salt, a ferric salt, a manganous salt, water, a dispersing material, and a phosphate to obtain a first mixture, and subjecting the first mixture to a first precipitation reaction to obtain a first reaction mixture containing the phosphate; adjusting a pH value of the first reaction mixture containing the phosphate to 10-12 by adding an alkali thereto to obtain a second mixture, subjecting the second mixture to a second precipitation reaction to obtain a second reaction mixture; and subjecting the second reaction mixture to a solid-liquid separation to obtain a solid, washing the solid, and drying to obtain the functional material for synchronously stabilizing multiple metals.

Abstract: This invention relates to the technical field of harmonic elimination for ferromagnetic resonance for a voltage transformer (abbreviated as PT), in particular, to a harmonic elimination method for ferromagnetic resonance for an active resistance-matching voltage transformer based on PID-adjustment, including compiling a resistance matching algorithm; designing and building a harmonic elimination control system based on the PID control strategy; presetting an active resistance-matching strategy; designing an engineering scheme for placing resistors.

Abstract: A system including an array of functional units connected via a two-dimensional mesh network is described. A first functional unit in the array of function units includes a memory device and a processing device, operatively coupled with the memory device, to perform operations including generating a node identifier identifying a second functional unit in the array of functional units, and transmitting, over the two-dimensional mesh network, the node identifier identifying the second functional unit in the array of functional units. The node identifier may include a mesh interface component and a port identifier, and one or more information elements selected from the group consisting of a payload, a target node identifier, a target type identifier, an information type identifier, a linear identifier, and a protocol identifier.

Abstract: A virtual wire system includes a source device, a target device, and a mesh interface connecting the source device and the target device. One or more mesh messages are transmitted over the mesh interface from the source device to the target device, and the one or more mesh messages indicate a change in a value of a signal level at the source device. The source device may include a plurality of virtual wire sources, a virtual wire encoder, and a virtual wire arbiter operatively coupled to the plurality of virtual wire sources and the virtual wire encoder. The virtual wire arbiter is configured to determine whether information from a virtual wire source should be transmitted to the virtual wire encoder. The virtual wire encoder is configured to receive information from the virtual wire arbiter, combine the information into a single virtual wire message, and transmit the single virtual wire message to a first mesh interface component in the source device.

Abstract: This application provides a data transmission method and an apparatus that are used for extended reality (XR) technologies. In a data transmission method disclosed herein, different parts of to-be-transmitted data are segmented into different code blocks (CBs), to mitigate impact of a transmission failure of one part of the to-be-transmitted data on another part of the to-be-transmitted data, thereby improving overall user experience in data reception. In this way, transmissions of low priority data and high priority data may be separated to avoid performance degradation caused by the low priority data on the high-priority data.

Abstract: Systems, methods, and computer program products can be used for visualizing the behavior of flow of two or more fluid phases, wherein a fluid phase behavior is represented in a visualization. One of the methods includes determining an occupation time, which is the amount of elapsed time from when a fluid phase first occupies a particular location until a second time. The method includes generating data for a visualization, with a location in the visualization corresponding to the particular location, and with the generated data for that location in the visualization indicating the occupation time.

Abstract: The present disclosure relates to HIF-2? inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2? scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice in vivo.