Abstract: Disclosed is a backlight assembly, including first and second light guide plates, and first and second light sources; light emitted by the first light source can be emitted from a surface of the first light guide plate facing the second light guide plate at a first set emitting angle, after being incident into the first light guide plate and reflected by a plurality of first microstructures disposed on a surface of the first light guide plate facing away from the second light guide plate; light emitted by the second light source can be emitted from a surface of the second light guide plate facing away from the first light guide plate at a second set emitting angle, after being incident into the second light guide plate and reflected by a plurality of second microstructures disposed on a surface of the second light guide plate facing the first light guide plate.

Abstract: Aspects of the disclosure provide compounds, compositions, and methods for modulating the expression or activity of plasma prekallikrein (PKK). In some aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of PKK mRNA in a cell or animal. In some aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of PKK protein in a cell or animal.

Abstract: A data verification method and apparatus, a device, and a storage medium are disclosed, and related to the field of data storage technologies. The verification method includes: during data verification, first verification information is obtained, according to a target algorithm, based on verification information of data, second verification information is obtained, according to the target algorithm, based on a target verification set determined based on a first verification set and a second verification set, and then the first verification information is compared with the second verification information, to obtain a verification result. The verification method can support a plurality of types of data operations, and improve a degree of parallel data processing while ensuring security and accuracy of data verification, thereby improving data processing efficiency.

Abstract: A benthonic animal isolation frame and a method for studying an aquatic ecosystem by using the same is provided. The benthonic animal isolation frame includes side surfaces and a bottom surface of the isolation frame as hollow structures. Joints of the side surfaces and the bottom surface are provided with clamping grooves. The bottom surface is provided with a filter membrane; and the filter membrane is fixed on the bottom surface through the clamping grooves. The benthonic animal isolation frame can be used for easily studying the influence of the benthonic animal and excrement thereof on a water body ecological system.

Abstract: A handheld digging tool includes a main body and a first drill rod mechanism with a first function. The main body is configured to be adapted for at least a second drill rod mechanism with a second function. The main body includes: a support mechanism; a drive mechanism supported by the support mechanism, including a direct current motor, and configured to be selectively connected to one of the first drill rod mechanism and the second drill rod mechanism to drive the first drill rod mechanism or the second drill rod mechanism to work; and a battery pack for supplying power to the direct current motor, where the nominal voltage of the battery pack is less than or equal to 80 V, and the maximum output torque of the handheld digging tool is greater than or equal to 80 N·m.

Abstract: A data intake and query system can manage the search of large amounts of data using one or more processing nodes. When a new processing node is added or becomes available, the node coordinator can reassign duties from one or more processing nodes to the new processing node. The node coordinator can initially assign the new processing node one or more groups of data for backup purposes. At a later time, the node coordinator can reassign the new processing node to the one or more groups of data for searching purposes.

Abstract: The present disclosure relates to the field of genetic engineering or enzyme engineering, and in particular to an application of MmPI in preparation of trypsin inhibitors. The amino acid sequence of the MmPI is shown in SEQ ID NO.1. The present disclosure clarifies for the first time that MmPI in mulberry leaves has trypsin inhibitory activity and reveals its physical and chemical properties. The MmPI has good application prospects in preparing trypsin inhibitors. On the basis of knowing the physical and chemical properties of the MmPI, its activity may be accordingly eliminated, thereby it promotes the development and utilization of mulberry leaf resources in animal feed, provides new perspectives and ideas for the development and utilization of mulberry leaves in animal feed and health food, and enhances the economic benefits of mulberry resources.

Abstract: The present disclosure relates to the field of genetic engineering or enzyme engineering, and in particular to an application of MmBBK2 in preparation of trypsin and chymotrypsin inhibitors. The MmBBK2 has the amino acid sequence shown in SEQ ID NO.1 or SEQ ID NO.2. The present disclosure clarifies for the first time that MmBBK2 in mulberry leaves has both trypsin and chymotrypsin inhibitory activity, and reveals its physical and chemical properties. The MmBBK2 has good application prospects in preparing trypsin and chymotrypsin inhibitors. On the basis of knowing its physical and chemical properties, its activity may be accordingly eliminated, promoting the development and utilization of mulberry leaf resources in animal feed, providing new perspectives and ideas for the development and utilization of mulberry leaves in animal feed and health food, and improving economic benefits of mulberry resources.

Abstract: RNAi agents for inhibiting the expression of the alpha-1 antitrypsin (AAT) gene, compositions including AAT RNAi agents, and methods of use are described. Also disclosed are pharmaceutical compositions including one or more AAT RNAi agents together with one or more excipients capable of delivering the RNAi agent(s) to a liver cell in vivo. Delivery of the AAT RNAi agent(s) to liver cells in vivo inhibits AAT gene expression and treats diseases associated with AAT deficiency such as chronic hepatitis, cirrhosis, hepatocellular carcinoma, transaminitis, cholestasis, fibrosis, and fulminant hepatic failure.

Abstract: Methods and systems are provided for determining the category of a software application utilizing machine learning (ML) and knowledge graph techniques, and for controlling access to the application by a user based on the category and configured time restrictions for the user. The system includes a feature set extractor and a category predictor with a trained ML model. The trained ML model generates the category of the application based on a feature(s) of the application. The generated category is indicated in a data structure. An access request handler receives a request related to access to the application from a user device. A category determiner determines the category of the application from the data structure. A time usage manager determines an available time usage for the category and the specified user. The access arbiter responds to the request from the user device with the available time usage.

Abstract: Provided herein are N-acetylgalactosamine (GalNAc)-derived compounds, modified oligonucleotides, and methods of modulating protein function and treating diseases, disorders, and symptoms in a subject.

Abstract: Synthetic ?v?6 integrin ligands of Formula I having serum stability and affinity for integrin ?v?6, which is a receptor expressed in a variety of cell types, are described. The described ligands are useful for delivering cargo molecules, such as RNAi agents or other oligonucleotide-based compounds, to cells that express integrin ?v?6, and thereby facilitating the uptake of the cargo molecules into these cells. Compositions that include ?v?6 integrin ligands and methods of use are also described.

Abstract: Aspects of the disclosure provide compounds, compositions, and methods for modulating the expression or activity of angiotensinogen (AGT). In some aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of AGT mRNA in a cell or animal. In some aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of AGT protein in a cell or animal.

Abstract: Aspects of the disclosure provide compounds, compositions, and methods for modulating the expression or activity of Complement Factor B (CFB). In certain aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of CFB mRNA in a cell or animal. In certain aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of CFB protein in a cell or animal.

Abstract: A pixel system for an imaging device can include one or more pixels comprising a pulse trigger assembly configured to detect a pulse at one or more threshold voltages, a timer system forming part of and/or connected to the one or more pixels, the timer system comprising one or more trigger switches. The pulse trigger assembly can be configured to activate the one or more trigger switches in response to detecting the pulse at the one or more threshold values. The pixel system can include a time-of-flight (TOF) module operatively connected to the one or more pixels and/or the timer system to determine a TOF based on an output from the timer system while simultaneously performing either or both passive imaging and asynchronous laser pulse detection.

Abstract: RNAi agents for inhibiting the expression of the alpha-1 antitrypsin (AAT) gene, compositions including AAT RNAi agents, and methods of use are described. Also disclosed are pharmaceutical compositions including one or more AAT RNAi agents together with one or more excipients capable of delivering the RNAi agent(s) to a liver cell in vivo. Delivery of the AAT RNAi agent(s) to liver cells in vivo inhibits AAT gene expression and treats diseases associated with AAT deficiency such as chronic hepatitis, cirrhosis, hepatocellular carcinoma, transaminitis, cholestasis, fibrosis, and fulminant hepatic failure.

Abstract: A positive electrode plate includes a positive electrode current collector and two positive electrode active material layers on both surfaces of the positive electrode current collector. The positive electrode active material layer includes a positive electrode active material and graphene. And 7.74?Dv501/2+0.05 THK?10.2, Dv50 is a particle size of the positive electrode active material and THK is a thickness of the positive electrode plate. And 0.078?w*CW+0.01n?1.9, n is a quantity of layers of the graphene, w is a mass percentage of the graphene in the positive electrode active layer, and CW is a one-side coating weight of the positive electrode active material layer.

Abstract: A voice call method is provided. The method includes: obtaining a voice call state of a terminal system at a historical moment, the terminal system being provided with at least two audio acquisition devices; obtaining first voice signals acquired by the at least two audio acquisition devices at a current moment, and determining signal energy of the first voice signals; and determining a target audio acquisition device at the current moment from the at least two audio acquisition devices based on the voice call state at the historical moment and the signal energy of the first voice signals.

Abstract: An image sensor having a set of pixels making up the image sensor to capture an image. Two or more pixels in the set of pixels each have an architecture that includes multiple photodiodes configurable to form an individual pixel. A control system can cooperate with the multiple photodiodes to form the individual pixel. Each of the multiple photodiodes can have a transfer gate electrically coupled to that photodiode. A common region can hold or transfer charge at least during or after an integration time. A read gate electrically coupled to the common region and a sense node, can supply charge from the common region through the read gate to the sense node.

Abstract: Systems, methods, and software are disclosed herein that provide a computer-based user experience that allows a user to consume information about physical and digital activities undertaken by one or more users. In an implementation, a software application on a computing device communicates with an online service to obtain activity information indicative of such activities, as well as activity topics produced by the service. The application groups the activities into activity groups based at least on the topics produced for the activities, and displays the activity groups in a user interface to the application.