Patents by Inventor Ruiko Oiwa

Ruiko Oiwa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4533547
    Abstract: A novel antiviral antibiotic AM-2722 is described represented by the molecular formula C.sub.19 H.sub.26 NO.sub.3 Cl, and having the following physicochemical properties:(1) specific rotary power: [.alpha.].sub.D.sup.20 -0.5 (C-1, chloroform);(2) the UV spectrum shown in FIG. 1; and(3) the IR spectrum shown in FIG. 2.Also described is a process for producing the antiviral antibiotic AM-2722, wherein a microorganism of Streptomyces which has the ability to produce the antibiotic AM-2722 is cultured aerobically in a nutrient medium and the antibiotic AM-2722 accumulated in the medium and the microorganism cells is recovered.
    Type: Grant
    Filed: May 11, 1981
    Date of Patent: August 6, 1985
    Assignee: The Kitasato Institute
    Inventors: Satoshi Omura, Akira Nakagawa, Hiroshi Hashimoto, Yasuhiko Kojima, Yuzuru Iwai, Ruiko Oiwa, Atsushi Hirano
  • Patent number: 4304859
    Abstract: There is disclosed a new antibiotic agent, A73A, produced by Streptomyces viridifaciens MA-4864 (ATCC 31495) under suitable conditions. Said antibiotic shows antibacterial and growth-permittant activity.
    Type: Grant
    Filed: October 27, 1980
    Date of Patent: December 8, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Ray S. Dewey, James E. Flor, Sheldon B. Zimmerman, Patrick J. Cassidy, Satoshi Omura, Ruiko Oiwa
  • Patent number: 4264607
    Abstract: There is disclosed a new antibiotic agent, A40A, produced by Streptomyces lavedulae MA-4758 (ATCC 31312) under suitable conditions. Said antibiotic shows antibacterial and growth-permittant activity.
    Type: Grant
    Filed: September 13, 1979
    Date of Patent: April 28, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Ray S. Dewey, Vincent P. Gulla, Sheldon B. Zimmerman, Satoshi Omura, Ruiko Oiwa
  • Patent number: 4262002
    Abstract: There is disclosed a new antibiotic agent, A73A, produced by Streptomyces viridifaciens MA-4864 (ATCC 31495) under suitable conditions. Said antibiotic shows antibacterial and growth-permittant activity.
    Type: Grant
    Filed: June 22, 1979
    Date of Patent: April 14, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Ray S. Dewey, James E. Flor, Sheldon B. Zimmerman, Patrick J. Cassidy, Satoshi Omura, Ruiko Oiwa
  • Patent number: 4226879
    Abstract: The present invention relates to a new composition designated as AM-1042 or asukamycin. AM-1042 has an antibiotic activity upon Gram-positive bacteria and Eimeria, and its acute toxicity (LD.sub.50 ' ip.) in mice was 48.5 mg./kg. AM-1042 has an excellent therapeutical effect on various infectious diseases caused by a parasite of Gram-positive bacteria and Eimeria. AM-1042 has been confirmed to be distinguishable from known antibiotics such as e.g. amicetin B, azomycin and manumycin. AM-1042 is produced by fermentation of a microorganism belonging to the genus Streptomyces and capable of producing AM-1042. A composition capable of preventing and curing coccidiosis of poultry containing AM-1042 as active ingredient.
    Type: Grant
    Filed: September 1, 1978
    Date of Patent: October 7, 1980
    Assignees: Kyowa Hakko Kogyo Kabushiki Kaisha, The Kitasato Institute
    Inventors: Satoshi Omura, Chiaki Kitao, Akira Nakagawa, Haruo Tanaka, Juichi Awaya, Ruiko Oiwa
  • Patent number: 4218478
    Abstract: Trichostatin (I) is disclosed to be useful as an antiprotozoal agent for the treatment of diseases in man and animals. Also disclosed are pharmaceutical compositions comprising trichostatin for treating protozoal infections.
    Type: Grant
    Filed: January 5, 1979
    Date of Patent: August 19, 1980
    Inventors: Satoshi Omura, Ruiko Oiwa
  • Patent number: 4199514
    Abstract: A novel compound frenolicin B of the formula: ##STR1## is prepared by cultivating a microorganism belonging to genus Streptomyces, e.g. Streptomyces roseofulvus AM-3867, in a culture medium and isolating the compound formed and accumulated in the medium from the cultured product. Said frenolicin B is useful as an antibiotic.
    Type: Grant
    Filed: January 25, 1979
    Date of Patent: April 22, 1980
    Assignee: The Kitasato Institute
    Inventors: Satoshi Omura, Yuzuru Iwai, Juichi Awaya, Yoko Takahashi, Ruiko Oiwa
  • Patent number: 3995028
    Abstract: The present invention relates to a new antibiotic designated as OS-3256-B. OS-3256-B exhibits excellent inhibitory activities against animal tumors such as leukemia L-1210, Sarcoma-180 and Hela cells and gram-positive bacteria and is classified into the diazocompounds group. However, chromatographic analysis, Rf value and other experimental data reveal that OS-3256-B is a new compound of the type of azaamino acid derivatives. The present invention also provides a process for producing OS-3256-B by fermentation, in which OS-3256-B is produced by culturing a microorganism belonging to Streptomyces candidus var. azaticus in a culture medium conventionally used for culturing Streptomyces strain microorganisms.
    Type: Grant
    Filed: August 21, 1975
    Date of Patent: November 30, 1976
    Assignee: The Kitasato Institute
    Inventors: Satoshi Omura, Iwao Umezawa, Keiki Satoh, Juichi Awaya, Kanki Komiyama, Ruiko Oiwa