Patents by Inventor Ruiming Zou
Ruiming Zou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240117362Abstract: Embodiments of the present disclosure relate to lipid-PEGylated solid support and phosphoramidites derivatives, methods for preparing the same, and their uses in the delivery of oligonucleotide drugs to the cellular targets.Type: ApplicationFiled: August 16, 2023Publication date: April 11, 2024Inventors: Mufa Zou, David Yu, Aldrich N.K. Lau, Ruiming Zou, Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Allen Wong, Xiaojun Li
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Patent number: 11897914Abstract: Embodiments of the present application relate to the preparation of 2?-O-protected nucleoside phosphoramidites and conjugation of the 2?-O-protected nucleoside to a solid support. More specifically, the present application relates to nucleosides having a hydroxy protecting group at the 2? position that reduces migration to the 3? position during RNA (e.g., mRNA) synthesis and can be readily removed under mild conditions without the use of toxic metal-containing reagents. Methods of using the nucleosides described herein in RNA synthesis are also disclosed.Type: GrantFiled: November 28, 2022Date of Patent: February 13, 2024Assignee: Hongene Biotech CorporationInventors: Wing C. Poon, Ruiming Zou, Aldrich N. K. Lau, David Yu, Gengyu Du, Yun-Chiao Yao, Gang Zhao
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Patent number: 11884691Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.Type: GrantFiled: May 18, 2023Date of Patent: January 30, 2024Assignee: Hongene Biotech CorporationInventors: Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Mufa Zou, Xiaoyang Guan, Xiaoling Zheng, David Yu, Ruiming Zou, Aldrich N. K. Lau
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Publication number: 20230416295Abstract: Embodiments of the present application relate to the preparation of 2?-O-protected nucleoside phosphoramidites and conjugation of the 2?-O-protected nucleoside to a solid support. More specifically, the present application relates to nucleosides having a hydroxy protecting group at the 2? position that reduces migration to the 3? position during RNA (e.g., mRNA) synthesis and can be readily removed under mild conditions without the use of toxic metal-containing reagents. Methods of using the nucleosides described herein in RNA synthesis are also disclosed.Type: ApplicationFiled: November 28, 2022Publication date: December 28, 2023Inventors: Wing C. Poon, Ruiming Zou, Aldrich N.K. Lau, David Yu, Gengyu Du, Yun-Chiao Yao, Gang Zhao
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Publication number: 20230340000Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.Type: ApplicationFiled: May 18, 2023Publication date: October 26, 2023Inventors: Wing C. POON, Gang ZHAO, Gengyu DU, Yun-Chiao YAO, Mufa ZOU, Xiaoyang GUAN, Xiaoling ZHENG, David YU, Ruiming ZOU, Aldrich N.K. LAU
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Publication number: 20230279041Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.Type: ApplicationFiled: December 13, 2022Publication date: September 7, 2023Inventors: Wing C. Poon, Xiaoyang Guan, David Yu, Ruiming Zou, Xiaojun Li, Michael Su, Gang Zhao, Gengyu Du, Yun-Chiao Yao
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Patent number: 11692001Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.Type: GrantFiled: August 26, 2022Date of Patent: July 4, 2023Assignee: Hongene Biotech CorporationInventors: Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Mufa Zou, Xiaoyang Guan, Xiaoling Zheng, David Yu, Ruiming Zou, Aldrich N. K. Lau
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Patent number: 11649260Abstract: Embodiments of the present application relate to N-acetylgalactosamine-conjugated nucleosides. In particular, the N-acetylgalactosamine is installed on the nucleobase of the nucleosides through a wide variety of linkers. Methods of making N-acetylgalactosamine-conjugated nucleosides are also disclosed herein. N-acetylgalactosamine is a well-defined liver-targeted moiety and N-acetylgalactosamine-conjugated nucleosides may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.Type: GrantFiled: June 16, 2022Date of Patent: May 16, 2023Assignee: Hongene Biotech CorporationInventors: Xiaoyang Guan, David Yu, Ruiming Zou, Xiaoling Zheng, John Liu, Aldrich N. K. Lau, Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao
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Publication number: 20230100220Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.Type: ApplicationFiled: August 26, 2022Publication date: March 30, 2023Inventors: Wing C. POON, Gang ZHAO, Gengyu DU, Yun-Chiao YAO, Mufa ZOU, Xiaoyang GUAN, Xiaoling ZHENG, David YU, Ruiming ZOU, Aldrich N.K. LAU
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Publication number: 20230034284Abstract: Embodiments of the present application relate to N-acetylgalactosamine-conjugated nucleosides. In particular, the N-acetylgalactosamine is installed on the nucleobase of the nucleosides through a wide variety of linkers. Methods of making N-acetylgalactosamine-conjugated nucleosides are also disclosed herein. N-acetylgalactosamine is a well-defined liver-targeted moiety and N-acetylgalactosamine-conjugated nucleosides may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.Type: ApplicationFiled: June 16, 2022Publication date: February 2, 2023Inventors: Xiaoyang Guan, David Yu, Ruiming Zou, Xiaoling Zheng, John Liu, Aldrich N.K. Lau, Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao
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Patent number: 9745336Abstract: The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.Type: GrantFiled: March 28, 2014Date of Patent: August 29, 2017Assignee: Applied Biosystems, LLCInventors: Ronald Graham, Ruiming Zou, Krishna Upadhya, Scott Benson
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Patent number: 9493656Abstract: Fluorescent phenyl xanthene dyes are described that comprise any fluorescein, rhodamine or rhodol comprising a particular C9 phenyl ring. One or both of the ortho groups on the lower C9 phenyl ring is ortho substituted with a group selected from alkyl, heteroalkyl, alkoxy, halo, haloalkyl, amino, mercapto, alkylthio, cyano, isocyano, cyanato, mercaptocyanato, nitroso, nitro, azido, sulfeno, sulfinyl, and sulfino. In one embodiment, halo and/or hydroxy groups are used. Optimal dyes contain a lower C9 phenyl ring in which both ortho groups are the same and the lower ring exhibits some form a symmetry relative to an imaginary axis running from the phenyl rings point of attachment to the remainder of the xanthene dye through a point para to the point of attachment. The phenyl xanthene dyes may be activated. Furthermore, the phenyl xanthene dyes may be conjugated to one or more substances including other dyes.Type: GrantFiled: June 16, 2015Date of Patent: November 15, 2016Assignee: Life Technologies CorporationInventors: Joe Y. L. Lam, Steven M. Menchen, Ruiming Zou, Scott C. Benson
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Publication number: 20150274975Abstract: Fluorescent phenyl xanthene dyes are described that comprise any fluorescein, rhodamine or rhodol comprising a particular C9 phenyl ring. One or both of the ortho groups on the lower C9 phenyl ring is ortho substituted with a group selected from alkyl, heteroalkyl, alkoxy, halo, haloalkyl, amino, mercapto, alkylthio, cyano, isocyano, cyanato, mercaptocyanato, nitroso, nitro, azido, sulfeno, sulfinyl, and sulfino. In one embodiment, halo and/or hydroxy groups are used. Optimal dyes contain a lower C9 phenyl ring in which both ortho groups are the same and the lower ring exhibits some form a symmetry relative to an imaginary axis running from the phenyl rings point of attachment to the remainder of the xanthene dye through a point para to the point of attachment. The phenyl xanthene dyes may be activated. Furthermore, the phenyl xanthene dyes may be conjugated to one or more substances including other dyes.Type: ApplicationFiled: June 16, 2015Publication date: October 1, 2015Inventors: Joe Y.L. LAM, Steven M. MENCHEN, Ruiming ZOU, Scott C. BENSON
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Patent number: 9090775Abstract: Fluorescent phenyl xanthene dyes are described that comprise any fluorescein, rhodamine or rhodol comprising a particular C9 phenyl ring. One or both of the ortho groups on the lower C9 phenyl ring is ortho substituted with a group selected from alkyl, heteroalkyl, alkoxy, halo, haloalkyl, amino, mercapto, alkylthio, cyano, isocyano, cyanato, mercaptocyanato, nitroso, nitro, azido, sulfeno, sulfinyl, and sulfino. In one embodiment, halo and/or hydroxy groups are used. Optimal dyes contain a lower C9 phenyl ring in which both ortho groups are the same and the lower ring exhibits some form a symmetry relative to an imaginary axis running from the phenyl rings point of attachment to the remainder of the xanthene dye through a point para to the point of attachment. The phenyl xanthene dyes may be activated. Furthermore, the phenyl xanthene dyes may be conjugated to one or more substances including other dyes.Type: GrantFiled: February 24, 2014Date of Patent: July 28, 2015Assignee: Applied Biosystems, LLCInventors: Joe Y. Lam, Steven Menchen, Ruiming Zou, Scott Benson
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Patent number: 9034920Abstract: Fluorescent polymeric materials are disclosed comprising a polymer and one or more lipid soluble rhodamine dyes with the following core structure: The materials are especially useful in the preparation of multicolored microparticles, especially multicolored polystyrene microparticles, for use in the multiplexed analysis of a plurality of analytes in a single sample. When excited by a light source, the materials give off a unique emission based on the nature, concentration and ratio of the dyes therein. Methods of preparing and using the fluorescent polymeric materials are also disclosed.Type: GrantFiled: November 26, 2013Date of Patent: May 19, 2015Assignee: Applied Biosystems, LLCInventors: Joe Y. L. Lam, Steven Menchen, Ruiming Zou, Scott Benson
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Publication number: 20140303003Abstract: The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.Type: ApplicationFiled: March 28, 2014Publication date: October 9, 2014Applicant: APPLIED BIOSYSTEMS, LLCInventors: Ronald Graham, Ruiming Zou, Krishna Upadhya, Scott Benson
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Publication number: 20140242665Abstract: Fluorescent phenyl xanthene dyes are described that comprise any fluorescein, rhodamine or rhodol comprising a particular C9 phenyl ring. One or both of the ortho groups on the lower C9 phenyl ring is ortho substituted with a group selected from alkyl, heteroalkyl, alkoxy, halo, haloalkyl, amino, mercapto, alkylthio, cyano, isocyano, cyanato, mercaptocyanato, nitroso, nitro, azido, sulfeno, sulfinyl, and sulfino. In one embodiment, halo and/or hydroxy groups are used. Optimal dyes contain a lower C9 phenyl ring in which both ortho groups are the same and the lower ring exhibits some form a symmetry relative to an imaginary axis running from the phenyl rings point of attachment to the remainder of the xanthene dye through a point para to the point of attachment. The phenyl xanthene dyes may be activated. Furthermore, the phenyl xanthene dyes may be conjugated to one or more substances including other dyes.Type: ApplicationFiled: February 24, 2014Publication date: August 28, 2014Applicant: APPLIED BIOSYSTEMS, LLCInventors: Joe Y. LAM, Steven MENCHEN, Ruiming ZOU, Scott BENSON
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Publication number: 20140145115Abstract: Fluorescent polymeric materials are disclosed comprising a polymer and one or more lipid soluble rhodamine dyes. The materials are especially useful in the preparation of multicolored microparticles, especially multicolored polystyrene microparticle, for use in the multiplexed analysis of a plurality of analytes in a single sample. When excited by a light source, the materials give off a unique emission based on the nature, concentration and ratio of the dyes therein. Methods of preparing and using said materials are also disclosed.Type: ApplicationFiled: November 26, 2013Publication date: May 29, 2014Applicant: Applied Biosystems, LLCInventors: Joe Y.L. LAM, Steven Menchen, Ruiming Zou, Scott Benson
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Patent number: 8729267Abstract: The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.Type: GrantFiled: June 21, 2011Date of Patent: May 20, 2014Assignee: Applied Biosystems, LLCInventors: Ronald Graham, Ruiming Zou, Krishna G. Upadhya, Scott C. Benson
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Patent number: 8618161Abstract: Fluorescent polymeric materials are disclosed comprising a polymeric particle and one or more lipid soluble rhodamine dyes, comprising the following core structure: wherein R11 and R15 are each H or are each F or Cl; R12, R13, and R14 are each H or are each F or Cl; and wherein at least one of R3?, R3?, R6? and R6? is a (C4-C20) alkyl. The materials are especially useful in the preparation of multicolored microparticles, especially multicolored polystyrene microparticle, for use in the multiplexed analysis of a plurality of analytes in a single sample. When excited by a light source, the materials give off a unique emission based on the nature, concentration and ratio of the dyes therein. Methods of preparing and using said materials are also disclosed.Type: GrantFiled: February 14, 2011Date of Patent: December 31, 2013Assignee: Applied Biosystems, LLCInventors: Joe Y. L. Lam, Steven M. Menchen, Ruiming Zou, Scott C. Benson