Patents by Inventor Ruiming Zou

Ruiming Zou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250027091
    Abstract: Embodiments of the present disclosure relate to lipid-PEGylated solid support and phosphoramidites derivatives, methods for preparing the same, and their uses in the delivery of oligonucleotide drugs to the cellular targets.
    Type: Application
    Filed: September 20, 2024
    Publication date: January 23, 2025
    Inventors: Mufa Zou, David Yu, Aldrich N.K. Lau, Ruiming Zou, Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Allen Wong, Xiaojun Li
  • Patent number: 12180140
    Abstract: The present disclosure relates to methods and compounds for liquid phase oligonucleotide synthesis employing the use of small molecules with lipophilic groups. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the compounds described herein are also provided.
    Type: Grant
    Filed: December 20, 2023
    Date of Patent: December 31, 2024
    Assignee: Hongene Biotech Corporation
    Inventors: Gaomai Yang, Min Xie, Hongrong Yang, Shengdong Wang, Aldrich N. K. Lau, Ruiming Zou, David Yu
  • Patent number: 12116382
    Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine analogs, methods of making, and uses of the same. In particular, polyvalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
    Type: Grant
    Filed: November 27, 2023
    Date of Patent: October 15, 2024
    Assignee: Hongene Biotech Corporation
    Inventors: Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Ruiming Zou, Aldrich N. K. Lau, David Yu, Guijun Yu, Zhixia Li
  • Patent number: 12098371
    Abstract: Embodiments of the present disclosure relate to lipid-PEGylated solid support and phosphoramidites derivatives, methods for preparing the same, and their uses in the delivery of oligonucleotide drugs to the cellular targets.
    Type: Grant
    Filed: August 16, 2023
    Date of Patent: September 24, 2024
    Assignee: Hongene Biotech Corporation
    Inventors: Mufa Zou, David Yu, Aldrich N. K. Lau, Ruiming Zou, Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Allen Wong, Xiaojun Li
  • Publication number: 20240287120
    Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
    Type: Application
    Filed: April 25, 2024
    Publication date: August 29, 2024
    Inventors: Wing C. Poon, Xiaoyang Guan, David Yu, Ruiming Zou, Xiaojun Li, Michael Su, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Aldrich N.K. Lau
  • Publication number: 20240247023
    Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine analogs, methods of making, and uses of the same. In particular, polyvalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
    Type: Application
    Filed: November 27, 2023
    Publication date: July 25, 2024
    Inventors: Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Ruiming Zou, Aldrich N.K. Lau, David Yu, Guijun Yu, Zhixia Li
  • Publication number: 20240228433
    Abstract: The present disclosure relates to methods and compounds for liquid phase oligonucleotide synthesis employing the use of small molecules with lipophilic groups. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the compounds described herein are also provided.
    Type: Application
    Filed: December 20, 2023
    Publication date: July 11, 2024
    Inventors: Gaomai YANG, Min XIE, Hongrong YANG, Shengdong WANG, Aldrich N.K. LAU, Ruiming ZOU, David YU
  • Patent number: 11993626
    Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
    Type: Grant
    Filed: December 13, 2022
    Date of Patent: May 28, 2024
    Assignee: Hongene Biotech Corporation
    Inventors: Wing C. Poon, Xiaoyang Guan, David Yu, Ruiming Zou, Xiaojun Li, Michael Su, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Aldrich N. K. Lau
  • Publication number: 20240117362
    Abstract: Embodiments of the present disclosure relate to lipid-PEGylated solid support and phosphoramidites derivatives, methods for preparing the same, and their uses in the delivery of oligonucleotide drugs to the cellular targets.
    Type: Application
    Filed: August 16, 2023
    Publication date: April 11, 2024
    Inventors: Mufa Zou, David Yu, Aldrich N.K. Lau, Ruiming Zou, Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Allen Wong, Xiaojun Li
  • Patent number: 11897914
    Abstract: Embodiments of the present application relate to the preparation of 2?-O-protected nucleoside phosphoramidites and conjugation of the 2?-O-protected nucleoside to a solid support. More specifically, the present application relates to nucleosides having a hydroxy protecting group at the 2? position that reduces migration to the 3? position during RNA (e.g., mRNA) synthesis and can be readily removed under mild conditions without the use of toxic metal-containing reagents. Methods of using the nucleosides described herein in RNA synthesis are also disclosed.
    Type: Grant
    Filed: November 28, 2022
    Date of Patent: February 13, 2024
    Assignee: Hongene Biotech Corporation
    Inventors: Wing C. Poon, Ruiming Zou, Aldrich N. K. Lau, David Yu, Gengyu Du, Yun-Chiao Yao, Gang Zhao
  • Patent number: 11884691
    Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
    Type: Grant
    Filed: May 18, 2023
    Date of Patent: January 30, 2024
    Assignee: Hongene Biotech Corporation
    Inventors: Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Mufa Zou, Xiaoyang Guan, Xiaoling Zheng, David Yu, Ruiming Zou, Aldrich N. K. Lau
  • Publication number: 20230416295
    Abstract: Embodiments of the present application relate to the preparation of 2?-O-protected nucleoside phosphoramidites and conjugation of the 2?-O-protected nucleoside to a solid support. More specifically, the present application relates to nucleosides having a hydroxy protecting group at the 2? position that reduces migration to the 3? position during RNA (e.g., mRNA) synthesis and can be readily removed under mild conditions without the use of toxic metal-containing reagents. Methods of using the nucleosides described herein in RNA synthesis are also disclosed.
    Type: Application
    Filed: November 28, 2022
    Publication date: December 28, 2023
    Inventors: Wing C. Poon, Ruiming Zou, Aldrich N.K. Lau, David Yu, Gengyu Du, Yun-Chiao Yao, Gang Zhao
  • Publication number: 20230340000
    Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
    Type: Application
    Filed: May 18, 2023
    Publication date: October 26, 2023
    Inventors: Wing C. POON, Gang ZHAO, Gengyu DU, Yun-Chiao YAO, Mufa ZOU, Xiaoyang GUAN, Xiaoling ZHENG, David YU, Ruiming ZOU, Aldrich N.K. LAU
  • Publication number: 20230279041
    Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
    Type: Application
    Filed: December 13, 2022
    Publication date: September 7, 2023
    Inventors: Wing C. Poon, Xiaoyang Guan, David Yu, Ruiming Zou, Xiaojun Li, Michael Su, Gang Zhao, Gengyu Du, Yun-Chiao Yao
  • Patent number: 11692001
    Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
    Type: Grant
    Filed: August 26, 2022
    Date of Patent: July 4, 2023
    Assignee: Hongene Biotech Corporation
    Inventors: Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Mufa Zou, Xiaoyang Guan, Xiaoling Zheng, David Yu, Ruiming Zou, Aldrich N. K. Lau
  • Patent number: 11649260
    Abstract: Embodiments of the present application relate to N-acetylgalactosamine-conjugated nucleosides. In particular, the N-acetylgalactosamine is installed on the nucleobase of the nucleosides through a wide variety of linkers. Methods of making N-acetylgalactosamine-conjugated nucleosides are also disclosed herein. N-acetylgalactosamine is a well-defined liver-targeted moiety and N-acetylgalactosamine-conjugated nucleosides may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
    Type: Grant
    Filed: June 16, 2022
    Date of Patent: May 16, 2023
    Assignee: Hongene Biotech Corporation
    Inventors: Xiaoyang Guan, David Yu, Ruiming Zou, Xiaoling Zheng, John Liu, Aldrich N. K. Lau, Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao
  • Publication number: 20230100220
    Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
    Type: Application
    Filed: August 26, 2022
    Publication date: March 30, 2023
    Inventors: Wing C. POON, Gang ZHAO, Gengyu DU, Yun-Chiao YAO, Mufa ZOU, Xiaoyang GUAN, Xiaoling ZHENG, David YU, Ruiming ZOU, Aldrich N.K. LAU
  • Publication number: 20230034284
    Abstract: Embodiments of the present application relate to N-acetylgalactosamine-conjugated nucleosides. In particular, the N-acetylgalactosamine is installed on the nucleobase of the nucleosides through a wide variety of linkers. Methods of making N-acetylgalactosamine-conjugated nucleosides are also disclosed herein. N-acetylgalactosamine is a well-defined liver-targeted moiety and N-acetylgalactosamine-conjugated nucleosides may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
    Type: Application
    Filed: June 16, 2022
    Publication date: February 2, 2023
    Inventors: Xiaoyang Guan, David Yu, Ruiming Zou, Xiaoling Zheng, John Liu, Aldrich N.K. Lau, Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao
  • Patent number: 9745336
    Abstract: The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: August 29, 2017
    Assignee: Applied Biosystems, LLC
    Inventors: Ronald Graham, Ruiming Zou, Krishna Upadhya, Scott Benson
  • Patent number: 9493656
    Abstract: Fluorescent phenyl xanthene dyes are described that comprise any fluorescein, rhodamine or rhodol comprising a particular C9 phenyl ring. One or both of the ortho groups on the lower C9 phenyl ring is ortho substituted with a group selected from alkyl, heteroalkyl, alkoxy, halo, haloalkyl, amino, mercapto, alkylthio, cyano, isocyano, cyanato, mercaptocyanato, nitroso, nitro, azido, sulfeno, sulfinyl, and sulfino. In one embodiment, halo and/or hydroxy groups are used. Optimal dyes contain a lower C9 phenyl ring in which both ortho groups are the same and the lower ring exhibits some form a symmetry relative to an imaginary axis running from the phenyl rings point of attachment to the remainder of the xanthene dye through a point para to the point of attachment. The phenyl xanthene dyes may be activated. Furthermore, the phenyl xanthene dyes may be conjugated to one or more substances including other dyes.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: November 15, 2016
    Assignee: Life Technologies Corporation
    Inventors: Joe Y. L. Lam, Steven M. Menchen, Ruiming Zou, Scott C. Benson