Abstract: Some embodiments disclosed herein pertain to indicator compounds used to detect the presence of and/or an amount of an analyte. In some embodiments, the indicator compounds are fusion proteins. In some embodiments, when the analyte binds to the indicator compound, the indicator compound undergoes a conformational change. In some embodiments, the conformational change results in a luminescent signal that allows quantification of the amount of analyte present.

Abstract: Systems, methods, and apparatuses for enabling a plurality of non-invasive, physiological sensors to obtain physiological measurements from essentially the same, overlapping, or proximate regions of tissue of a patient are disclosed. Each of a plurality of sensors can be integrated with or attached to a multi-sensor apparatus and can be oriented such that each sensor is directed towards, or can obtain a measurement from, the same or a similar location.

Abstract: A noninvasive physiological sensor can include a first body portion and a second body portion coupled to each other and configured to at least partially enclose a user's finger. The sensor can further include a first probe coupled to one or more emitters and a second probe coupled to a detector. The first probe can direct light emitted from the one or more emitters toward tissue of the user's finger and the second probe can direct light attenuated through the tissue to the detector. The first and second probes can be coupled to the first and second body portions such that when the first and second body portions are rotated with respect to one another, ends of the first and second probes can be moved in a direction towards one another to compress the tissue of the user's finger.

Abstract: A noninvasive physiological sensor can include a first body portion and a second body portion coupled to each other and configured to at least partially enclose a user's finger. The sensor can further include a first probe coupled to one or more emitters and a second probe coupled to a detector. The first probe can direct light emitted from the one or more emitters toward tissue of the user's finger and the second probe can direct light attenuated through the tissue to the detector. The first and second probes can be coupled to the first and second body portions such that when the first and second body portions are rotated with respect to one another, ends of the first and second probes can be moved in a direction towards one another to compress the tissue of the user's finger.

Abstract: Systems, methods, apparatuses, and medical devices for harmonizing data from a plurality of non-invasive sensors are described. A physiological parameter can be determined by harmonizing data between two or more different types of non-invasive physiological sensors interrogating the same or proximate measurement sites. Data from one or more first non-invasive sensors can be utilized to identify one or more variables that are useful in one or more calculations associated with data from one or more second non-invasive sensors. Data from one or more first non-invasive sensors can be utilized to calibrate one or more second non-invasive sensors. Non-invasive sensors can include, but are not limited to, an optical coherence tomography (OCT) sensor, a bio-impedance sensor, a tissue dielectric constant sensor, a plethysmograph sensor, or a Raman spectrometer.

Abstract: Systems, methods, apparatuses, and medical devices for harmonizing data from a plurality of non-invasive sensors are described. A physiological parameter can be determined by harmonizing data between two or more different types of non-invasive physiological sensors interrogating the same or proximate measurement sites. Data from one or more first non-invasive sensors can be utilized to identify one or more variables that are useful in one or more calculations associated with data from one or more second non-invasive sensors. Data from one or more first non-invasive sensors can be utilized to calibrate one or more second non-invasive sensors. Non-invasive sensors can include, but are not limited to, an optical coherence tomography (OCT) sensor, a bio-impedance sensor, a tissue dielectric constant sensor, a plethysmograph sensor, or a Raman spectrometer.

Abstract: Some embodiments disclosed herein pertain to indicator compounds used to detect the presence of and/or an amount of an analyte. In some embodiments, the indicator compounds are fusion proteins. In some embodiments, when the analyte binds to the indicator compound, the indicator compound undergoes a conformational change. In some embodiments, the conformational change results in a luminescent signal that allows quantification of the amount of analyte present.

Abstract: Systems, methods, and apparatuses for enabling a plurality of non-invasive, physiological sensors to obtain physiological measurements from essentially the same, overlapping, or proximate regions of tissue of a patient are disclosed. Each of a plurality of sensors can be integrated with or attached to a multi-sensor apparatus and can be oriented such that each sensor is directed towards, or can obtain a measurement from, the same or a similar location.

Abstract: A noninvasive physiological sensor can include a first body portion and a second body portion coupled to each other and configured to at least partially enclose a user's finger. The sensor can further include a first probe coupled to one or more emitters and a second probe coupled to a detector. The first probe can direct light emitted from the one or more emitters toward tissue of the user's finger and the second probe can direct light attenuated through the tissue to the detector. The first and second probes can be coupled to the first and second body portions such that when the first and second body portions are rotated with respect to one another, ends of the first and second probes can be moved in a direction towards one another to compress the tissue of the user's finger.

Abstract: Systems, methods, and apparatuses for enabling a plurality of non-invasive, physiological sensors to obtain physiological measurements from the same tissue site. Each of a plurality of sensors can be integrated with or attached to a multi-sensor apparatus. The multi-sensor apparatus can orient the plurality of non-invasive, physiological sensors such that each of the plurality of non-invasive, physiological sensors obtains physiological data from the same or a similar location.