Abstract: Provided is a group of peripheral blood gene markers for screening benign and malignant pulmonary micro-nodules, comprising: gene sequences characterized by micronodular lung carcinoma as shown in SEQ ID NOs. 1-6, wherein the gene sequences exhibit differential expression in the peripheral blood of micronodular lung carcinoma patients and non-micronodular lung carcinoma patients. In addition, also provided is the use of the above-mentioned gene markers in preparing a product for early screening micronodular lung carcinoma. The gene markers of the invention used for early screening micronodular lung carcinoma, have high sensitivity and strong specificity; besides, they take peripheral blood, which is the easiest to collect in clinic, as the test sample.

Abstract: The invention discloses a genetic marker used for identifying benign and malignant pulmonary micro-nodules, the genetic marker comprises: the feature genes of lung carcinoma indicated by SEQ ID NO.1˜SEQ ID NO.12, and the genes in peripheral blood between are significantly different between patients with micronodular lung carcinoma and patients without lung carcinoma. The invention also discloses the application of the genetic markers or any combination therein in preparing products for early screening of lung carcinoma. The genetic marker of invention used for the early screening of high-risk lung carcinoma has high sensitivity and strong specificity; besides, it takes peripheral blood, which is the easiest to collect in clinic, as the test sample.