Abstract: A new leuco dye produces a yellow color while demonstrating also exceptional light and thermal stability under light.

Abstract: The present invention relates to a loaded particle comprising at least one fluorescent dye, and in particular, a fluorescent dye with a large Stokes shift. The invention further relates to a method for producing an loaded latex particle, loaded with a fluorescent dye having a large stokes shift. In addition, the present invention relates to latex particles loaded with fluorescent dyes that are organic solvent soluble and insoluble in water. In a preferred embodiment, when the dyes are loaded into the water soluble latex particle, an increase is observed in quantum yield of fluorescence as compared to the quantum yield of the dye in aqueous solvent.

Abstract: A negative-working lithographic printing plate precursor is designed for improved printout or contrast between exposed and non-exposed regions in its imageable layer. The imaged precursor can be developed on-press. The improvement in printout is achieved by using a combination of at least two infrared radiation absorbing cyanine dyes. At least one of these cyanine dyes comprises a methine chain substituent that comprises a group represented by Structure (I): wherein Q1 and Q2 are hydrogen atoms or the same or different monovalent substituents, or Q1 and Q2 together provide carbon or heteroatoms to form a substituted or unsubstituted unsaturated ring. At least one other infrared radiation absorbing cyanine dyes does not comprise a group represented by Structure (I).

Abstract: A color contrast image in imaged lithographic printing precursors can be obtained by contacting the imaged precursor with a coloration solution containing a colorless form of a photochromic compound. Residual amounts of this compound attached to the oleophilic surface of the imaged precursor can be changed to its colored form when exposed to UV light. The coloration solution can be an alkaline or acidic developer or an alkaline or acidic solution used separately after development. The coloration solution can also be a gum solution.

Abstract: The present invention relates to a loaded particle comprising at least one fluorescent dye, and in particular, a fluorescent dye with a large Stokes shift. The invention further relates to a method for producing an loaded latex particle, loaded with a fluorescent dye having a large stokes shift. In addition, the present invention relates to latex particles loaded with fluorescent dyes that are organic solvent soluble and insoluble in water. In a preferred embodiment, when the dyes are loaded into the water soluble latex particle, an increase is observed in quantum yield of fluorescence as compared to the quantum yield of the dye in aqueous solvent.

Abstract: A color contrast image in imaged lithographic printing precursors can be obtained by contacting the imaged precursor with a coloration solution containing a colorless form of a photochromic compound. Residual amounts of this compound attached to the oleophilic surface of the imaged precursor can be changed to its colored form when exposed to UV light. The coloration solution can be an alkaline or acidic developer or an alkaline or acidic solution used separately after development. The coloration solution can also be a gum solution.

Abstract: A negative-working imageable element has an imageable layer that includes an infrared radiation absorbing dye that upon exposure to thermal irradiation, changes from colorless to a visible color or from one visible color to another visible color, providing a ?E of at least 5 between the exposed and non-exposed regions of the imageable layer within 3 hours of its exposure to 300 mJ/cm2 at a laser power of 15 Watts. The imageable element can be imaged to provide images with improved contrast for print-out. The imageable layer includes a primary polymeric binder that has a backbone to which are attached pendant poly(alkylene oxide) side chains, cyano groups, or both, and is optionally present in the form of discrete particles.

Abstract: The present invention relates to a diagnostic contrast agent comprising a water dispersible, near-infrared tricarbocyanine, enamine-functionalized dye having a Stoke shift of greater than 50 and represented by five general formulae. The present invention also relates to a method for making a dye-conjugate utilizing the novel dye and a method of identifying a biological compound using the novel dye conjugate.

Abstract: A method and apparatus for delivering a mixture of compressed fluid and marking material and depositing the marking material in a pattern onto a substrate, includes a high pressure source of a mixture of compressed fluid and marking material. A micro-machined manifold includes a plurality of micro-nozzles, a fluid chamber, and an entrance port with portions of a first surface of the micro-machined manifold defining the entrance port with the entrance port being connected in fluid communication with the fluid chamber. Each of the micro-nozzles having an inlet and an outlet with the inlet being connected in fluid communication with the fluid chamber and the outlet being located on the second surface of the micro-machined manifold. Each micro-nozzle is shaped to produce a directed beam of the mixture of compressed fluid and marking material beyond the outlet of the micro-nozzle.

Abstract: On press developable negative-working, on-press developable imageable elements have improved printout qualities with an incorporated infrared radiation absorbing compound that has a cyanine dye chromophore that is represented by the following Structure (CHROMOPHORE): wherein one or both of Q1 and Q2 are independently substituted or unsubstituted acyl groups —(C?O)—R3? and —(C?O)—R4? respectively, wherein R3? and R4? are independently substituted or unsubstituted alkyl or aryl groups, or they are joined together to form a ring structure, or one of Q1 and Q2 is hydrogen and the other is a substituted or unsubstituted acyl group, A and A? are independently —S—, —O—, —NH—, —CH2—, or —CR?R?— groups wherein R? and R? are independently substituted or unsubstituted alkyl groups, or R? and R? together can form a substituted or unsubstituted cyclic group, Z represents the carbon atoms needed to form a 5- to 7-membered carbocyclic ring, Z1 and Z2 are independently substituted or unsubstituted benzo or naphtho conden

Abstract: A negative-working imageable element has an imageable layer that includes an infrared radiation absorbing dye that upon exposure to thermal irradiation, changes from colorless to a visible color or from one visible color to another visible color, providing a ?E of at least 5 between the exposed and non-exposed regions of the imageable layer within 3 hours of its exposure to 300 mJ/cm2 at a laser power of 15 Watts. The imageable element can be imaged to provide images with improved contrast for print-out. The imageable layer includes a primary polymeric binder that has a backbone to which are attached pendant poly(alkylene oxide) side chains, cyano groups, or both, and is optionally present in the form of discrete particles.

Abstract: A nanoparticulate imaging probe with an oxide core, a biocompatible polymeric shell covalently attached to the oxide core, a dye, and a cleavable spacer that covalently binds the dye to the probe. When the spacer is cleaved, the dye is liberated from the probe. The emissions of the dye are quenched when the dye is bound to the probe and not quenched when the dye is liberated from the probe. The spacer can be, for example, a peptide. The oxide core can be, for example, a silicon oxide core.

Abstract: A nanoparticulate imaging probe with an oxide core, a biocompatible polymeric shell covalently attached to the oxide core, a dye, and a cleavable spacer that covalently binds the dye to the probe. When the spacer is cleaved, the dye is liberated from the probe. The emissions of the dye are quenched when the dye is bound to the probe and not quenched when the dye is liberated from the probe. The spacer can be, for example, a peptide. The oxide core can be, for example, a silicon oxide core.

Abstract: An apparatus for multimodal imaging of an object includes a support stage for receiving an object to be imaged; an object supported on the stage, the object having been treated with a biocompatible imaging probe comprising nanoparticles carrying one or more targeting moieties and one or more diagnostic components for enabling capture of images of the object; a light source for producing a beam to illuminate the object; a filter positioned to receive and pass the beam toward the object; and a lens and camera system for capturing an image of the object. The apparatus may include a tiltable filter for filtering light from the source.

Abstract: A method and apparatus for delivering a mixture of compressed fluid and marking material and depositing the marking material in a pattern onto a substrate, includes a high pressure source of a mixture of compressed fluid and marking material. A micro-machined manifold includes a plurality of micro-nozzles, a fluid chamber, and an entrance port with portions of a first surface of the micro-machined manifold defining the entrance port with the entrance port being connected in fluid communication with the fluid chamber. Each of the micro-nozzles having an inlet and an outlet with the inlet being connected in fluid communication with the fluid chamber and the outlet being located on the second surface of the micro-machined manifold. Each micro-nozzle is shaped to produce a directed beam of the mixture of compressed fluid and marking material beyond the outlet of the micro-nozzle.

Abstract: There are disclosed colloids containing polymer-modified core-shell particle carrier. The described colloids containing core-shell nanoparticulate carrier particles wherein the shell contains a polymer having amine functionalities. The described carrier particles are stable under physiological conditions. The carriers can be bioconjugated with biological, pharmaceutical or diagnostic components.

Abstract: The present invention relates to a diagnostic contrast agent comprising a water dispersible, near-infrared tricarbocyanine, enamine-functionalized dye having a Stoke shift of greater than 50 and represented by five general formulae. The present invention also relates to a method for making a dye-conjugate utilizing the novel dye and a method of identifying a biological compound using the novel dye conjugate.

Abstract: The present invention relates to a loaded latex particle comprising a latex material made from a mixture represented by formula (X)m-(Y)n-(Z)o-(W)p, wherein Y is at least one monomer with at least two ethylenically unsaturated chemical functionalities; Z is at least one polyethylene glycol macromonomer with an average molecular weight of between 300 and 10,000; W is an ethylenic monomer different from X, Y, or Z; and X is at least one water insoluble, alkoxethyl containing monomer; and m, n, o, and p are the respective weight percentages of each monomer. The particle may be loaded with a fluorescent dye.

Abstract: The present invention relates to a nanoparticle comprising self-assembled crosslinked, amphiphilic block copolymers and at least one immobilized dye, wherein the self-assembled, crosslinked, amphiphilic block copolymers comprise a hydrophilic block and a hydrophobic block, wherein the self-assembled, crosslinked, amphiphilic block copolymers are self-assembled to form a core of the nanoparticle comprising a hydrophobic block, wherein the hydrophobic block is derived from at least one pendant multifunctional crosslinked alkoxy silane or amino silane moiety, and an exterior of the nanoparticle comprising a hydrophilic block, and wherein the immobilized dye is immobilized in the core.

Abstract: Disclosed is a dye combination and thermal dye transfer imaging element and imaging method comprising a yellow dye donor containing a combination of two or more yellow dyes, the combination of dyes exhibiting an RMS error of less than 0.015. Such dye combinations provide improved color matching vs. target colors.