Patents by Inventor RuLin Fan

RuLin Fan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Industrial preparation method for high-purity dicycloplatin needle-like crystal
    Patent number: 10995109
    Abstract: Provided is an industrial preparation method for a high-purity dicycloplatin needle-like crystal, comprising: mixing and reacting carboplatin and 1,1-cyclobutane dicarboxylic acid and water, crystallizing same to obtain a dicycloplatin needle-like crystal with a yield of more than 85%, and a utilization rate of the precious metal platinum of more than 97%. The method is green and environmentally friendly and is suitable for industrial production.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: May 4, 2021
    Inventors: Qinhua Song, Rulin Fan, Jianke Feng
  • INDUSTRIAL PREPARATION METHOD FOR HIGH-PURITY DICYCLOPLATIN NEEDLE-LIKE CRYSTAL
    Publication number: 20200140472
    Abstract: Provided is an industrial preparation method for a high-purity dicycloplatin needle-like crystal, comprising: mixing and reacting carboplatin and 1,1-cyclobutane dicarboxylic acid and water, crystallizing same to obtain a dicycloplatin needle-like crystal with a yield of more than 85%, and a utilization rate of the precious metal platinum of more than 97%. The method is green and environmentally friendly and is suitable for industrial production.
    Type: Application
    Filed: June 20, 2018
    Publication date: May 7, 2020
    Inventors: Qinhua SONG, Rulin FAN, Jianke FENG
  • Reagents and methods for preparing LPS antagonist B1287 and stereoisomers thereof
    Patent number: 8399634
    Abstract: The present invention provides methods for preparing LPS antagonist lipodisaccharide B1287 and stereoisomers thereof, which compounds are useful as in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic shock. Also provided are synthetic intermediates useful for implementing the inventive methods.
    Type: Grant
    Filed: February 4, 2011
    Date of Patent: March 19, 2013
    Assignee: Eisai R&D Management Co., Ltd.
    Inventor: RuLin Fan
  • REAGENTS AND METHODS FOR PREPARING LPS ANTAGONIST B1287 AND STEREOISOMERS THEREOF
    Publication number: 20110152508
    Abstract: The present invention provides methods for preparing LPS antagonist lipodisaccharide B1287 and stereoisomers thereof, which compounds are useful as in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic shock. Also provided are synthetic intermediates useful for implementing the inventive methods.
    Type: Application
    Filed: February 4, 2011
    Publication date: June 23, 2011
    Applicant: Eisai R&D Management Co., Ltd.
    Inventor: RuLin Fan
  • Reagents and methods for preparing LPS antagonist B1287 and stereoisomers thereof
    Patent number: 7906633
    Abstract: The present invention provides methods for preparing LPS antagonist lipodisaccharide B1287 and stereoisomers thereof, which compounds are useful as in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic shock. Also provided are synthetic intermediates useful for implementing the inventive methods.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: March 15, 2011
    Assignee: Eisai R&D Management Co., Ltd.
    Inventor: RuLin Fan
  • Reagents and methods for preparing lps antagonist b1287 and stereoisomers thereof
    Publication number: 20060160999
    Abstract: The present invention provides methods for preparing LPS antagonist lipodisaccharide B1287 and stereoisomers thereof, which compounds are useful as in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic shock. Also provided are synthetic intermediates useful for implementing the inventive methods.
    Type: Application
    Filed: February 18, 2004
    Publication date: July 20, 2006
    Inventor: Rulin Fan
  • Isoprenyl transferase inhibitors
    Patent number: 5840918
    Abstract: Peptidomimetic compounds useful in the treatment of Ras-associated human cancers, and other conditions mediated by farnesylated or geranylgeranylated proteins; and synthetic intermediates thereof.
    Type: Grant
    Filed: March 19, 1997
    Date of Patent: November 24, 1998
    Assignee: Eisai Co., Ltd.
    Inventors: Michael D. Lewis, James J. Kowalczyk, Amy E. Christuk, Rulin Fan, Edmund M. Harrington, Xiaoning C. Sheng, Hu Yang, Ana Maria Garcia, Ieharu Hishinuma, Takeshi Nagasu, Kentaro Yoshimatsu