Patents by Inventor Rulin Ma

Rulin Ma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted Imidazopyrazine Compounds as IRAK3 Binders
    Publication number: 20260234148
    Abstract: Provided herein are compounds and compositions thereof that bind to IRAK3.
    Type: Application
    Filed: July 24, 2023
    Publication date: August 13, 2026
    Applicant: Celgene Corporation
    Inventors: Farid van der Mei, Guobin Miao, Rulin Ma, Laura Akullian D'Agostino, Kurt Armbrust
  • Substituted Pyrazolyl-Pyridinyl Compounds as Ligand Directed Degraders of IRAK3
    Publication number: 20260234124
    Abstract: Provided herein are compounds and compositions thereof for modulating IRAK3. In some embodiments, the compounds and compositions are provided for treatment of cancer.
    Type: Application
    Filed: July 24, 2023
    Publication date: August 13, 2026
    Applicant: Celgene Corporation
    Inventors: Farid van der Mei, Guobin Miao, Rulin Ma, Laura Akullian D'Agostino, Kurt Armbrust
  • Substituted Imidazo-Based Compounds as Ligand Directed Degraders of IRAK3
    Publication number: 20260216347
    Abstract: Provided herein are compounds and compositions thereof for modulating IRAK3. In some embodiments, the compounds and compositions are provided for treatment of cancer.
    Type: Application
    Filed: December 20, 2023
    Publication date: July 30, 2026
    Applicant: Celgene Corporation
    Inventors: Farid van der Mei, Guobin Miao, Laura Akullian D'Agostino, Rulin Ma, Kurt Armbrust
  • Heterocyclic Compounds as Modulators of S1P5
    Publication number: 20260209203
    Abstract: Provided herein are compounds and compositions thereof for modulating S1P5. In some embodiments, the compounds and compositions are provided for treatment of neurological diseases.
    Type: Application
    Filed: December 14, 2023
    Publication date: July 23, 2026
    Applicant: Celgene Corporation
    Inventors: Jean-Francois Brazeau, Rulin Ma, Jeffrey M. Schkeryantz, Karin Worm, Patrick W. Papa
  • Carboxylic acid containing azetidinyl compounds for the treatment of neurodegenerative diseases
    Patent number: 12552771
    Abstract: Provided herein are compounds and compositions thereof for modulating S1P5. In some embodiments, the compounds and compositions are provided for treatment of neurological diseases.
    Type: Grant
    Filed: January 25, 2024
    Date of Patent: February 17, 2026
    Assignee: Celgene Corporation
    Inventors: Jeffrey M. Schkeryantz, Karin Worm, Rulin Ma, Patrick W. Papa
  • Substituted Imidazopyrazine Compounds as Ligand Directed Degraders of IRAK3
    Publication number: 20260028343
    Abstract: Provided herein are compounds and compositions thereof for modulating IRAK3. In some embodiments, the compounds and compositions are provided for treatment of cancer.
    Type: Application
    Filed: July 24, 2023
    Publication date: January 29, 2026
    Applicant: Celgene Corporation
    Inventors: Farid van der Mei, Guobin Miao, Rulin Ma, Laura Akullian D'Agostino, Kurt Armbrust
  • Compounds for the Treatment of Neurodegenerative Diseases
    Publication number: 20260022094
    Abstract: Provided herein are compounds and compositions thereof for modulating S1P5. In some embodiments, the compounds and compositions are provided for treatment of neurological diseases.
    Type: Application
    Filed: July 17, 2023
    Publication date: January 22, 2026
    Applicant: Celgene Corporation
    Inventors: Jean-Francois Brazeau, Rulin Ma, Jeffrey M. Schkeryantz, Karin Worm, Patrick W. Papa
  • ESTROGEN RECEPTOR ALPHA DEGRADERS AND METHODS OF USE THEREOF
    Publication number: 20250388565
    Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for degrading ER? with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with ER?-mediated transcription regulation with the compounds and compositions of the disclosure.
    Type: Application
    Filed: June 27, 2023
    Publication date: December 25, 2025
    Inventors: Alexander M. Taylor, Kurt Armbrust, Christopher A. Lepre, Thomas H. McLean, Paul R. Fleming, Rulin MA, Erich W. Baum, Cary Griffin Fridrich, Jing He, Charles R. Heap, Jay F. Larrow, Rukundo Ntaganda
  • Carboxylic Acid Containing Indanyl Compounds for the Treatment of Neurodegenerative Diseases
    Publication number: 20240376048
    Abstract: Provided herein are compounds and compositions thereof for modulating S1P5. In some embodiments, the compounds and compositions are provided for treatment of neurological diseases. Formula (I).
    Type: Application
    Filed: December 7, 2022
    Publication date: November 14, 2024
    Applicant: Celgene Corporation
    Inventors: Jean-Francois Brazeau, Rulin Ma, Jeffrey M. Schkeryantz, Karin Worm, Patrick W. Papa
  • Carboxylic Acid Containing Azetidinyl Compounds for the Treatment of Neurodegenerative Diseases
    Publication number: 20240270714
    Abstract: Provided herein are compounds and compositions thereof for modulating S1P5. In some embodiments, the compounds and compositions are provided for treatment of neurological diseases.
    Type: Application
    Filed: January 25, 2024
    Publication date: August 15, 2024
    Applicant: Celgene Corporation
    Inventors: Jeffrey M. Schkeryantz, Karin Worm, Rulin Ma, Patrick W. Papa
  • Heteroaryl Compounds as Ligand Directed Degraders of IRAK4
    Publication number: 20240109881
    Abstract: Provided herein are compounds and compositions thereof for modulating IRAK4. In some embodiments, the compounds and compositions are provided for treatment of inflammatory or autoimmune diseases.
    Type: Application
    Filed: July 19, 2023
    Publication date: April 4, 2024
    Applicants: Bristol-Myers Squibb Company, Celgene Corporation
    Inventors: Timothy Rasmusson, Geraint Davies, Paul Gormisky, Rulin Ma, Michael Ellis, Lingbowei Hu, Tony Siu, Farid van der Mei, Harry Hager, Yilin Meng
  • Carboxylic acid containing azetidinyl compounds for the treatment of neurodegenerative diseases
    Patent number: 11919879
    Abstract: Provided herein are compounds and compositions thereof for modulating S1P5. In some embodiments, the compounds and compositions are provided for treatment of neurological diseases.
    Type: Grant
    Filed: June 15, 2022
    Date of Patent: March 5, 2024
    Assignee: Celgene Corporation
    Inventors: Jeffrey M. Schkeryantz, Karin Worm, Rulin Ma, Patrick W. Papa
  • Carboxylic Acid Containing Azetidinyl Compounds for the Treatment of Neurodegenerative Diseases
    Publication number: 20230028747
    Abstract: Provided herein are compounds and compositions thereof for modulating S1P5. In some embodiments, the compounds and compositions are provided for treatment of neurological diseases.
    Type: Application
    Filed: June 15, 2022
    Publication date: January 26, 2023
    Applicant: Celgene Corporation
    Inventors: Jeffrey M. Schkeryantz, Karin Worm, Rulin Ma, Patrick W. Papa
  • Sulfoxide ligand metal catalyzed oxidation of olefins
    Patent number: 10266503
    Abstract: The enantioselective synthesis of isochroman motifs has been accomplished via Pd(II)-catalyzed allylic C—H oxidation from terminal olefin precursors. Critical to the success of this goal was the development and utilization of a novel chiral aryl sulfoxide-oxazoline (ArSOX) ligand. The allylic C—H oxidation reaction proceeds with the broadest scope and highest levels asymmetric induction reported to date (avg. 92% ee, 13 examples ?90% ee). Additionally, C(sp3)-N fragment coupling reaction between abundant terminal olefins and N-triflyl protected aliphatic and aromatic amines via Pd(II)/sulfoxide (SOX) catalyzed intermolecular allylic C—H amination is disclosed. A range of 52 allylic amines are furnished in good yields (avg. 76%) and excellent regio- and stereoselectivity (avg. >20:1 linear:branched, >20:1 E:Z).
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: April 23, 2019
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: M. Christina White, Stephen E. Ammann, Wei Liu, Rulin Ma