Patents by Inventor Rulin Ma

Rulin Ma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heteroaryl Compounds as Ligand Directed Degraders of IRAK4
    Publication number: 20240109881
    Abstract: Provided herein are compounds and compositions thereof for modulating IRAK4. In some embodiments, the compounds and compositions are provided for treatment of inflammatory or autoimmune diseases.
    Type: Application
    Filed: July 19, 2023
    Publication date: April 4, 2024
    Applicants: Bristol-Myers Squibb Company, Celgene Corporation
    Inventors: Timothy Rasmusson, Geraint Davies, Paul Gormisky, Rulin Ma, Michael Ellis, Lingbowei Hu, Tony Siu, Farid van der Mei, Harry Hager, Yilin Meng
  • Carboxylic acid containing azetidinyl compounds for the treatment of neurodegenerative diseases
    Patent number: 11919879
    Abstract: Provided herein are compounds and compositions thereof for modulating S1P5. In some embodiments, the compounds and compositions are provided for treatment of neurological diseases.
    Type: Grant
    Filed: June 15, 2022
    Date of Patent: March 5, 2024
    Assignee: Celgene Corporation
    Inventors: Jeffrey M. Schkeryantz, Karin Worm, Rulin Ma, Patrick W. Papa
  • Carboxylic Acid Containing Azetidinyl Compounds for the Treatment of Neurodegenerative Diseases
    Publication number: 20230028747
    Abstract: Provided herein are compounds and compositions thereof for modulating S1P5. In some embodiments, the compounds and compositions are provided for treatment of neurological diseases.
    Type: Application
    Filed: June 15, 2022
    Publication date: January 26, 2023
    Applicant: Celgene Corporation
    Inventors: Jeffrey M. Schkeryantz, Karin Worm, Rulin Ma, Patrick W. Papa
  • Sulfoxide ligand metal catalyzed oxidation of olefins
    Patent number: 10266503
    Abstract: The enantioselective synthesis of isochroman motifs has been accomplished via Pd(II)-catalyzed allylic C—H oxidation from terminal olefin precursors. Critical to the success of this goal was the development and utilization of a novel chiral aryl sulfoxide-oxazoline (ArSOX) ligand. The allylic C—H oxidation reaction proceeds with the broadest scope and highest levels asymmetric induction reported to date (avg. 92% ee, 13 examples ?90% ee). Additionally, C(sp3)-N fragment coupling reaction between abundant terminal olefins and N-triflyl protected aliphatic and aromatic amines via Pd(II)/sulfoxide (SOX) catalyzed intermolecular allylic C—H amination is disclosed. A range of 52 allylic amines are furnished in good yields (avg. 76%) and excellent regio- and stereoselectivity (avg. >20:1 linear:branched, >20:1 E:Z).
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: April 23, 2019
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: M. Christina White, Stephen E. Ammann, Wei Liu, Rulin Ma