Abstract: It discloses a fibroblast growth factor 21 variant, a fusion protein comprising such fibroblast growth factor 21 variant, a GLP-1 variant and a FC sequence, and a use thereof. The fusion protein of the present invention has high activity, long half-life and a novel structure, and can significantly decrease blood sugar, body weight, and improve fat metabolism. The present invention also provides a fusion gene, an expression construct, and a host cell comprising an encoding nucleotide sequence of the fusion protein, and a use of the fusion protein, the fusion gene, the expression construct, the host cell, and the pharmaceutical composition in the preparation of drugs for treating obesity, hyperlipidemia, diabetes, and cardiovascular and cerebrovascular diseases.

Abstract: The present invention provides a sphingosine kinase 1, a fusion protein comprising the same, and a use thereof. The sphingosine kinase 1 and the fusion protein comprising the same have significant effects in lowering blood sugar and body weight, and are useful for the preparations of protein drugs for controlling metabolic diseases such as obesity and diabetes. It also provides a protein drug, which is a fusion protein containing a sphingosine kinase 1 or an amino acid sequence having the activity thereof. The fusion protein comprises a sphingosine kinase 1 (SPHK1) or an amino acid sequence having the activity thereof, a FC sequence and a linker sequence. The protein drug can significantly decrease blood sugar, blood fat and body weight, and improve fat metabolism.