Abstract: The present invention relates to benzimidazole derivatives of formula (I) as inhibitors of retinoid-related orphan receptor gamma (ROR?) protein, pharmaceutical compositions containing the compounds, preparation methods thereof, and the use of the compounds as therapeutic agents for the treatment of ROR?-mediated diseases or disorders.

Abstract: The present invention relates to benzimidazole derivatives of formula (I) as inhibitors of retinoid-related orphan receptor gamma (ROR?) protein, pharmaceutical compositions containing the compounds, preparation methods thereof, and the use of the compounds as therapeutic agents for the treatment of ROR?-mediated diseases or disorders.

Abstract: This application discloses CD73 inhibitors represented by the general formula (I) and analogs thereof, pharmaceutical compositions containing these compounds, methods of preparing them, and use of these compounds as therapeutic agents for the treatment of diseases or conditions associated with CD73 activity, such as various cancers.

Abstract: This application discloses CD73 inhibitors represented by the general formula (I) and analogs thereof, pharmaceutical compositions containing these compounds, methods of preparing them, and use of these compounds as therapeutic agents for the treatment of diseases or conditions associated with CD73 activity, such as various cancers.

Abstract: The present invention relates to benzimidazole derivatives of formula (I) as inhibitors of retinoid-related orphan receptor gamma (ROR?) protein, pharmaceutical compositions containing the compounds, preparation methods thereof, and the use of the compounds as therapeutic agents for the treatment of ROR?-mediated diseases or disorders.

Abstract: The embodiment of the present application provides a method and apparatus for detection of false alarm obstacle, and relates to the field of identification and detection technology, in order to improve accuracy for the obstacle detection. The method includes: obtaining a first view at a moment t and a second view at a moment t?1, collected by a camera; determining location information of the same obstacle to be detected in the first view and the second view; determining motion information of the camera from moment t?1 to the moment t; judging whether the location information of the same obstacle to be detected in two views being matched with the motion information of the camera; and if not, judging the obstacle to be detected as a false alarm obstacle. The embodiment of the present application is applied to obstacle detection.

Abstract: A deuterium atom-substituted indole formamide derivative, a preparation method therefor, and medical applications thereof. Specifically, the present invention relates to a deuterium atom-substituted indole formamide derivative represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, and uses of the derivative serving as an ROR agonist and uses of the derivative in preventing and/or treating tumors or cancers, definitions of substituent groups in general formula (I) being same as definitions in the specification.

Abstract: A solid dispersion, a method for preparing same, and a solid preparation comprising the solid dispersion. The solid dispersion contains (R)-4-amino-1-(1-(but-2-ynylacyl)pyrrolidin-3-yl)-3-(4-(2,6-difluorophenoxy)phenyl)-1,6-dihydro-7H-pyrrolo[2,3-d]pyridazine-7-one or a pharmaceutically acceptable salt thereof, and a carrier material. The carrier material is selected from hydroxypropyl methylcellulose acetate succinate and hydroxypropyl methylcellulose phthalate.

Abstract: The embodiment of the present application provides a method and apparatus for detection of false alarm obstacle, and relates to the field of identification and detection technology, in order to improve accuracy for the obstacle detection. The method includes: obtaining a first view at a moment t and a second view at a moment t-1, collected by a camera; determining location information of the same obstacle to be detected in the first view and the second view; determining motion information of the camera from moment t-1 to the moment t; judging whether the location information of the same obstacle to be detected in two views being matched with the motion information of the camera; and if not, judging the obstacle to be detected as a false alarm obstacle. The embodiment of the present application is applied to obstacle detection.

Abstract: The present disclosure provides a visual navigation method and a visual navigation device. The method may include steps of: obtaining a plurality of ambient sub-images for a collected ambient image based on the collected ambient image; performing a region-matching process on each of the ambient sub-images to determine a disparity between at least two of the ambient sub-images; and determining coordinates of an object in the ambient image based on the determined disparity, and performing a navigation based on the determined coordinates. In the present disclosure, the ambient image is collected by a single camera, the plurality of ambient sub-images is obtained by the micro-lens array based on the collected ambient image, and then stereo matching and three-dimensional (3D) reconstruction are implemented based on the ambient sub-images to perform the visual navigation.

Abstract: The present disclosure provides a visual navigation method and a visual navigation device. The method may include steps of: obtaining a plurality of ambient sub-images for a collected ambient image based on the collected ambient image; performing a region-matching process on each of the ambient sub-images to determine a disparity between at least two of the ambient sub-images; and determining coordinates of an object in the ambient image based on the determined disparity, and performing a navigation based on the determined coordinates. In the present disclosure, the ambient image is collected by a single camera, the plurality of ambient sub-images is obtained by the micro-lens array based on the collected ambient image, and then stereo matching and three-dimensional (3D) reconstruction are implemented based on the ambient sub-images to perform the visual navigation.

Abstract: The present invention discloses modified Hdm2 proteins that are soluble. In addition, the present invention discloses nucleic acids that encode the modified Hdm2 proteins of the present invention. The invention also provides crystals of modified Hdm2 proteins that are suitable for X-ray crystallization analysis. The present invention also discloses methods of using the modified Hdm2 proteins and crystals thereof to identify, select and/or design compounds that may be used as anticancer agents. The present invention further discloses compounds that bind to modified Hdm2 proteins in protein-ligand complexes.

Abstract: The present invention relates to HDM2 polypeptides and mutants thereof which are complexed with various compounds, e.g., HDM2 inhibitors.

Abstract: In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.

Abstract: The present invention relates to HDM2 polypeptides and mutants thereof which are complexed with various compounds, e.g., HDM2 inhibitors.

Abstract: The present invention discloses modified Hdm2 proteins that are soluble. In addition, the present invention discloses nucleic acids that encode the modified Hdm2 proteins of the present invention. The invention also provides crystals of modified Hdm2 proteins that are suitable for X-ray crystallization analysis. The present invention also discloses methods of using the modified Hdm2 proteins and crystals thereof to identify, select and/or design compounds that may be used as anticancer agents. The present invention further discloses compounds that bind to modified Hdm2 proteins in protein-ligand complexes.

Abstract: The present invention provides, inter alia, peptide compositions and methods for treating and preventing Flaviviridae virus (e.g., HCV) infections.

Abstract: The present invention relates to HDM2 polypeptides and mutants thereof which are complexed with various compounds, e.g., HDM2 inhibitors.

Abstract: The present invention discloses modified Hdm2 proteins that are soluble. In addition, the present invention discloses nucleic acids that encode the modified Hdm2 proteins of the present invention. The invention also provides crystals of modified Hdm2 proteins that are suitable for X-ray crystallization analysis. The present invention also discloses methods of using the modified Hdm2 proteins and crystals thereof to identify, select and/or design compounds that may be used as anticancer agents. The present invention further discloses compounds that bind to modified Hdm2 proteins in protein-ligand complexes.

Abstract: The present invention provides, inter alia, peptide compositions and methods for treating and preventing Flaviviridae virus (e.g., hepatitis C virus) infections.