Abstract: Provided is a novel peripherally restricted multi-target cyclopeptide molecule for an opioid receptor and a neuropeptide FF (NPFF) receptor, or a pharmaceutically acceptable salt thereof. By using DN-9 as a chemical template, structural optimization is performed on opioid peptide and NPFF pharrnacophores by means of polypeptide chemical strategies such as amino acid replacement and cyclization modification to obtain a series of cyclopeptide molecules. The cyclopeptide molecules can activate both opioid receptors and NPFF receptors, and the analgesic activity and the analgesic duration thereof are greatly increased compared with parent DN-9 molecules, and opioid side effects such as analgesic tolerance, constipation, and addiction are reduced.

Abstract: The present disclosure relates to systems, methods, and computer-readable media for pre-provisioning server nodes of a server rack and causing the pre-provisioned server node to be deployed on an edge zone of a cloud computing system. In particular, systems described herein involve identifying server nodes based on a customer hardware deployment request and performing a series of pre-provision acts to the server nodes in accordance with the received hardware deployment request. For example, systems described herein pre-provision the hardware by configuring hardware and software on the server nodes, establishing communication with one or more control planes on a datacenter, and bringing the server nodes to a return to web (RTW) state. By pre-provisioning the hardware, the server hardware may be delivered and transitioned to a live state in an efficient manner and without jeopardizing security on the cloud.