Abstract: Provided is a novel peripherally restricted multi-target cyclopeptide molecule for an opioid receptor and a neuropeptide FF (NPFF) receptor, or a pharmaceutically acceptable salt thereof. By using DN-9 as a chemical template, structural optimization is performed on opioid peptide and NPFF pharrnacophores by means of polypeptide chemical strategies such as amino acid replacement and cyclization modification to obtain a series of cyclopeptide molecules. The cyclopeptide molecules can activate both opioid receptors and NPFF receptors, and the analgesic activity and the analgesic duration thereof are greatly increased compared with parent DN-9 molecules, and opioid side effects such as analgesic tolerance, constipation, and addiction are reduced.

Abstract: A method and system for pretreating waste plastics and a method and system for producing an automotive fuel from waste plastics are provided. The method for pretreating waste plastics includes the steps of: 1) contacting a waste plastic with a pretreating agent and a solvent oil for impurity removal; and 2) subjecting the effluent from step 1) to solid-liquid separation to obtain an insoluble material and an impurity-removed plastic-containing solution. The impurity-removed plastic-containing solution obtained by the method and system for pretreating waste plastics has very low metal content, chlorine content and silicon content.

Abstract: A microsphere of oxide has an opening on its surface connected to a hollow core inside, forming a cavity. The oxide the microsphere is made of is selected from the group consisting of alumina, silica, zirconia, magnesium oxide, calcium oxide and titania. The microsphere of oxide shows better mass and heat transfer characteristics, and has strength significantly higher than that of existing products with similar structures. A FT synthesis catalyst has the microsphere of oxide as a support and an active metal component disposed on the support. The active metal component is one or more selected from the group consisting of Co, Fe, and Ru.