Abstract: Methods for observing the activity of compounds, cells, and cell components during a cellular event are provided. Such live cell observation allows one to assess the function and impact of various compounds and other molecules upon the biochemical pathways responsible for the event. Embodiments of the present invention describe the live cell observation of compounds' effects on PTTG during mitosis; specifically, the ramifications that such effects may have on treating aneuploidy and/or cancer. Alternate embodiments of the present invention describe the combination of the live cell method with high throughput screening, to efficiently identify and examine compounds for a desirable effect on a cellular event, such as compounds that may be effective in the treatment of aneuploidy or cancer.

Abstract: Disclosed is a method of modulating angiogenesis in a tissue comprising mammalian cells, including cells of human origin, in vitro or in vivo. Also disclosed are a method of enhancing wound healing and/or tissue regeneration and a method of limiting scar formation.