Abstract: An electroporation device having a handle section, a set of electrodes, and an electrode guide assembly. The handle section is operatively connected to an elongate introducer shaft, which has a longitudinal axis and a distal tip. The set of electrodes includes respective distal electrode tips. The electrode guide assembly is arranged inside the elongate introducer shaft and includes a set of electrode channels with each electrode channel guiding one or several electrodes. Each electrode is slidably arranged within an electrode channel between (a) a retracted position, where the distal electrode tips are enclosed inside the introducer shaft, and (b) an advanced position, where the distal electrode tips project to an outside of the introducer shaft. A set of longitudinally extending tip electrode channels are arranged in the distal tip and adapted to guide respective travel trajectories of the distal electrode tips during electrode advancement and retraction.