Patents by Inventor Rune Kjeken

Rune Kjeken has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230001190
    Abstract: Described is a device and method for administration of molecules to tissue in vivo for various medical applications, the device comprising a single hypodermic injection needle and at least two spaced elongate electrodes which provide for the ability, when the needle is inserted into tissue, such as skin or muscle, to pulse tissue with a non-uniform electric field sufficient to cause reversible poration of cells lying along or in close proximity to the track made by the needle upon its insertion into said tissue.
    Type: Application
    Filed: April 29, 2022
    Publication date: January 5, 2023
    Inventors: Rune KJEKEN, Iacob MATHIESEN, Torunn Elisabeth TJELLE, George MCHUGH
  • Patent number: 11331479
    Abstract: Described is a device and method for administration of molecules to tissue in vivo for various medical applications, the device comprising a single hypodermic injection needle and at least two spaced elongate electrodes which provide for the ability, when the needle is inserted into tissue, such as skin or muscle, to pulse tissue with a non-uniform electric field sufficient to cause reversible poration of cells lying along or in close proximity to the track made by the needle upon its insertion into said tissue.
    Type: Grant
    Filed: July 9, 2019
    Date of Patent: May 17, 2022
    Assignee: Inovio Pharmaceuticals, Inc.
    Inventors: Rune Kjeken, Iacob Mathiesen, Elisabeth Torunn Tjelle, George McHugh
  • Publication number: 20210353939
    Abstract: The present invention relates to dual depth electroporation devices capable of electorporating both muscle tissue and skin tissue in a single application in order to generate a broad immune response in a subject, and uses of the same.
    Type: Application
    Filed: July 27, 2021
    Publication date: November 18, 2021
    Inventors: Kate Broderick, Feng LIN, Jay McCoy, Stephen V. Kemmerrer, Rune KJEKEN
  • Patent number: 11097099
    Abstract: The present invention relates to dual depth electroporation devices capable of electorporating both muscle tissue and skin tissue in a single application in order to generate a broad immune response in a subject, and uses of the same.
    Type: Grant
    Filed: March 1, 2011
    Date of Patent: August 24, 2021
    Assignee: Inovio Pharmaceuticals, Inc.
    Inventors: Kate Broderick, Feng Lin, Jay McCoy, Stephen V Kemmerrer, Rune Kjeken
  • Publication number: 20200289818
    Abstract: This invention comprises an improved electroporation electrode system comprising a single needle and a ring or donut shaped electrode wherein the difference in surface area of the electrodes provide for a substantial reduction of current density near the surface of the treated tissue and a more concentrated current density sufficient for electroporation only in tissues adjacent to the terminal portion of the single needle electrode. Thus, this invention provides for targeting specific tissue for electroporation and also should provide for lessening the sensation of electric current in the treated tissue.
    Type: Application
    Filed: February 28, 2020
    Publication date: September 17, 2020
    Inventors: Rune KJEKEN, Stephen Vincent KEMMERRER, Feng LIN, Dietmar RABUSSAY, Thomas Joseph KARDOS
  • Patent number: 10610684
    Abstract: This invention comprises an improved electroporation electrode system comprising a single needle and a ring or donut shaped electrode wherein the difference in surface area of the electrodes provide for a substantial reduction of current density near the surface of the treated tissue and a more concentrated current density sufficient for electroporation only in tissues adjacent to the terminal portion of the single needle electrode. Thus, this invention provides for targeting specific tissue for electroporation and also should provide for lessening the sensation of electric current in the treated tissue.
    Type: Grant
    Filed: July 14, 2010
    Date of Patent: April 7, 2020
    Assignee: Genetronics, Inc.
    Inventors: Rune Kjeken, Stephen Vincent Kemmerrer, Feng Lin, Dietmar Rabussay, Thomas Joseph Kardos
  • Publication number: 20200001076
    Abstract: Described is a device and method for administration of molecules to tissue in vivo for various medical applications, the device comprising a single hypodermic injection needle and at least two spaced elongate electrodes which provide for the ability, when the needle is inserted into tissue, such as skin or muscle, to pulse tissue with a non-uniform electric field sufficient to cause reversible poration of cells lying along or in close proximity to the track made by the needle upon its insertion into said tissue.
    Type: Application
    Filed: July 9, 2019
    Publication date: January 2, 2020
    Inventors: Rune KJEKEN, Iacob MATHIESEN, Elisabeth Torunn TJELLE, George McHUGH
  • Patent number: 10369359
    Abstract: Described is a device and method for administration of molecules to tissue in vivo for various medical applications, the device comprising a single hypodermic injection needle and at least two spaced elongate electrodes which provide for the ability, when the needle is inserted into tissue, such as skin or muscle, to pulse tissue with a non-uniform electric field sufficient to cause reversible poration of cells lying along or in close proximity to the track made by the needle upon its insertion into said tissue.
    Type: Grant
    Filed: February 9, 2007
    Date of Patent: August 6, 2019
    Assignee: Genetronics, Inc.
    Inventors: Rune Kjeken, Iacob Mathiesen, Elisabeth Torunn Tjelle, George McHugh
  • Publication number: 20190167983
    Abstract: Devices and methods for delivering an electropermeabilizing pulse of electric energy to a tissue surface to enable delivery into cells in the tissue therapeutic substances. The device incorporates a source capable of generating a sufficient voltage potential to deliver a spark across a gap and delivers same to the tissue surface.
    Type: Application
    Filed: February 11, 2019
    Publication date: June 6, 2019
    Applicant: VGX Pharmaceuticals, LLC
    Inventors: Thomas Joseph KARDOS, Stephen Vincent KEMMERRER, Rune KJEKEN, Kate BRODERICK, Jay MCCOY, Michael P. FONS
  • Patent number: 10232173
    Abstract: Devices and methods for delivering an electropermeabilizing pulse of electric energy to a tissue surface to enable delivery into cells in the tissue therapeutic substances. The device incorporates a source capable of generating a sufficient voltage potential to deliver a spark across a gap and delivers same to the tissue surface.
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: March 19, 2019
    Assignee: VGX Pharmaceuticals, LLC
    Inventors: Thomas Joseph Kardos, Stephen Vincent Kemmerer, Rune Kjeken, Kate Broderick, Jay McCoy, Michael P Fons
  • Publication number: 20130066296
    Abstract: A novel electroporation device for the delivery of vaccines that is both effective in generating a protective immune response and tolerable delivery to a subject (or near painless); and also methods of using same device to vaccinate a subject against a variety of infectious diseases and types of cancer in a near painless.
    Type: Application
    Filed: March 1, 2011
    Publication date: March 14, 2013
    Inventors: Kate Broderick, Jay McCoy, Stephen V. Kemmerrer, Feng Lin, Rune Kjeken
  • Publication number: 20120323165
    Abstract: The present invention relates to dual depth electroporation devices capable of electorporating both muscle tissue and skin tissue in a single application in order to generate a broad immune response in a subject, and uses of the same.
    Type: Application
    Filed: March 1, 2011
    Publication date: December 20, 2012
    Inventors: Kate Broderick, Feng Lin, Jay McCoy, Stephen V. Kemmerrer, Rune Kjeken
  • Publication number: 20120046598
    Abstract: Devices and methods for delivering an electropermeabilizing pulse of electric energy to a tissue surface to enable delivery into cells in the tissue therapeutic substances. The device incorporates a source capable of generating a sufficient voltage potential to deliver a spark across a gap and delivers same to the tissue surface.
    Type: Application
    Filed: April 16, 2010
    Publication date: February 23, 2012
    Applicant: VGX PHARMACEUTICALS, LLC
    Inventors: Thomas Joseph Kardos, Stephen Vincent Kemmerer, Rune Kjeken, Kate Broderick, Jay McCoy, Michael P Fons
  • Publication number: 20110009807
    Abstract: This invention comprises an improved electroporation electrode system comprising a single needle and a ring or donut shaped electrode wherein the difference in surface area of the electrodes provide for a substantial reduction of current density near the surface of the treated tissue and a more concentrated current density sufficient for electroporation only in tissues adjacent to the terminal portion of the single needle electrode. Thus, this invention provides for targeting specific tissue for electroporation and also should provide for lessening the sensation of electric current in the treated tissue.
    Type: Application
    Filed: July 14, 2010
    Publication date: January 13, 2011
    Applicant: GENETRONICS, INC.
    Inventors: Rune KJEKEN, Stephen Vincent KEMMERRER, Feng LIN, Dietmar RABUSSAY, Thomas Joseph KARDOS
  • Publication number: 20100285040
    Abstract: Disclosed are methods of enhancing immune responses. Such methods involve the administration of vaccine compositions to different tissues to elicit an enhanced immune response. The enhanced response arises from the vaccination and boosting route of administration in two separate patient tissues, for example, by first administering a priming vaccination into skin and later administering a boost vaccination in muscle. In each case, priming and boosting, the administration of the vaccine composition is preferably carried out using contemporaneous electroporation-assisted delivery of the antigenic agent.
    Type: Application
    Filed: November 16, 2007
    Publication date: November 11, 2010
    Inventors: Iacob Mathiesen, Torunn Elisabeth Tjelle, Rune Kjeken, Dietmar Paul Rabussay, Feng Lin
  • Publication number: 20080287857
    Abstract: Described is a device and method for administration of molecules to tissue in vivo for various medical applications, the device comprising a single-needle electrode which provides for the ability, when the needle is inserted into tissue, such as skin or muscle, to pulse tissue with a non-uniform electric field sufficient to cause reversible poration of cells lying along or in close proximity to the track made by the needle upon its insertion into said tissue
    Type: Application
    Filed: August 20, 2007
    Publication date: November 20, 2008
    Inventors: Rune Kjeken, Iacob Mathiesen, Torunn Elisabeth Tjelle, George McHugh
  • Publication number: 20080045880
    Abstract: Described is a device and method for administration of molecules to tissue in vivo for various medical applications, the device comprising a single-needle electrode which provides for the ability, when the needle is inserted into tissue, such as skin or muscle, to pulse tissue with a non-uniform electric field sufficient to cause reversible poration of cells lying along or in close proximity to the track made by the needle upon its insertion into said tissue
    Type: Application
    Filed: May 18, 2007
    Publication date: February 21, 2008
    Inventors: Rune Kjeken, Iacob Mathiesen, Elisabeth Tjelle, George McHugh
  • Publication number: 20070287950
    Abstract: Described is a device and method for administration of molecules to tissue in vivo for various medical applications, the device comprising a single hypodermic injection needle and at least two spaced elongate electrodes which provide for the ability, when the needle is inserted into tissue, such as skin or muscle, to pulse tissue with a non-uniform electric field sufficient to cause reversible poration of cells lying along or in close proximity to the track made by the needle upon its insertion into said tissue.
    Type: Application
    Filed: February 9, 2007
    Publication date: December 13, 2007
    Inventors: Rune Kjeken, Iacob Mathiesen, Elisabeth Tjelle, George McHugh