Abstract: A method and system for determining a route map and a route for a vehicle. Generating the route map comprises obtaining historical data comprising a plurality of data points for each of a plurality of vehicles from storage and determining a plurality of nodes each representing a subset of the data points. The historical data is applied to the plurality of nodes to determine the closest node for each vehicle. The nodes are ordered for each of the plurality of vehicles in the historical data by time; and a directed edge is generated between a first and second node of the plurality of ordered nodes, based on when the historical data indicates that a given vehicle has transited from the first node and the second node. A route is determined for the vehicle based on the generated route map and outputted route to a control system.

Abstract: The invention relates to a macromolecule comprising a polymer central core having at least two atoms to which at least two monomers are attached forming a dendrimeric structure comprising at least three polymer bonds, at least two linear polymers (b) being bond to said polymer bonds, wherein said polymers (b) at least have terminal functional groups for cytotoxic agents and at least on extended polymer (a) having a size of at least 1 carbon atoms longer than said polymers (b) and at least a terminal functional group for a targeting agent. The invention also relates to a macromolecule conjugate as well as a macromolecule biotin conjugate comprising said macromolecule, methods to produce said macromolecules as well as kits or system comprising said macromolecules and method of treating a mammal by said macromolecules.

Abstract: A method for the conditioning of an extracorporeal device is described, as well as method for extracorporeal extraction of toxic material from mammalian body fluids in connection with diagnosis or treatment of a mammalian condition or disease, in which methods reagents having the ability to extract toxic material from mammalian body fluids are involved, and an extracorporeal device comprising said reagent.

Abstract: The invention relates to a macromolecule comprising a polymer central core having at least two atoms to which at least two monomers are attached forming a dendrimeric structure comprising at least three polymer bonds, at least two linear polymers (b) being bond to said polymer bonds, wherein said polymers (b) at least have terminal functional groups for cytotoxic agents and at least on extended polymer (a) having a size of at least 1 carbon atoms longer than said polymers (b) and at least a terminal functional group for a targeting agent. The invention also relates to a macromolecule conjugate as well as a macromolecule biotin conjugate comprising said macromolecule, methods to produce said macromolecules as well as kits or system comprising said macromolecules and method of treating a mammal by said macromolecules.

Abstract: The invention relates to an adsorption device for removal and/or reduction of undesirable components from blood, such as whole blood, comprising, porous cross-linked polysaccharide particles or beads, wherein the particles or beads have an average size from about 210±50 ?m, at least 30% of the particles have a size from about 180 to about 240 ?m, at least 70% of the particles have a size from about 150 to about 300 ?m and said particles have at least one immobilised ligand, wherein said immobilised ligand have a size of about 150 kD or less. The invention also relates to kits comprising said adsorption device as well as the use of said adsorption device in different applications such as cleaning of blood.

Abstract: A conjugate comprising a) a trifunctional cross-linking moiety, to which is coupled b) an affinity ligand via a linker 1, c) a cytotoxic agent, optionally via a linker 2, and d) an anti Erb antibody or variants thereof having the ability to bind to Erb antigens expressed on mammalian tumour surfaces with an affinity-binding constant of at least 5×106 M?1, wherein the affinity ligand is biotin, or a biotin derivative having essentially the same binding function to avidin or streptavidin as biotin, wherein stability towards enzymatic cleavage of the biotinamide bond has been introduced in linker 1.

Abstract: A medical agent comprising a reagent conjugated to an anti-lymphoma antibody is disclosed, as well as a kit containing said medical agent, use of said medical agent, and a method for treatment of lymphoma. The reagent may comprise an effector, e.g. an antitumor agent or a diagnostic marker, and an affinity ligand enabling extracorporeal clearance of the agent. The three components are bound by a trifunctional linker.

Abstract: At least one alkyl paraben is used in an aqueous antimicrobial preservation composition for eliminating or reducing the microbial content of a microbially contaminated separation matrix, which is to be used in a housing of a separation device, the separation matrix being microbially contaminated. Also, in a method of producing a separation matrix with eliminated or reduced microbial content, the method comprises the steps of providing said separation matrix, microbially contaminated, in a housing or container; adding an aqueous antimicrobial preservation composition, which comprises at least one alkyl paraben, to said separation matrix in said housing or container; allowing said aqueous antimicrobial preservation composition to exert its effect in said housing or container until the number of colony forming units (CFU) per g preservative composition is sufficiently reduced; and rinsing said aqueous antimicrobial preservation composition from said housing or container.

Abstract: The present invention provide methods to improve the treatment of cancer in mammals, including ovarian cancer, where intraperitoneal administration of cytotoxic medical agents or immunoconjugates are utilized. The invention provides means of substantially reducing the level of cytotoxic medical agents or immunoconjugates in the circulating blood. Hence, the organ exposure of circulating cytotoxic agents is minimized using the invention and the invention offers opportunities to use more effective dose treatment regime.

Abstract: A method for the conditioning of an extracorporeal device is described, as well as method for extracorporeal extraction of toxic material from mammalian body fluids in connection with diagnosis or treatment of a mammalian condition or disease, in which methods reagents having the ability to extract toxic material from mammalian body fluids are involved, and an extracorporeal device comprising said reagent.

Abstract: An apparatus for use in connection with removal of elements, especially exogenous antibodies, from blood or plasma flowing in an extracorporeal blood circulation system of a patient, where said apparatus comprises a container (1). This container is adapted to receive an adsorbent and comprises an inlet (15) and an outlet (16) which are adapted to be connected to an inlet conduit (19) and an outlet conduit (20), respectively, forming part of the blood circulation system. The container (1) comprises an inlet chamber (31), an adsorption chamber (32) adapted to receive the adsorbent, and an outlet chamber (33). These chambers are arranged in sequence when seen in the flow direction of the blood or the plasma through the container (1) and are separated by means of filter units (11, 12) allowing passage of the blood or the plasma. The inlet (15) and the outlet (16) are arranged adjacent one another in connection with a common movable valve means (21).

Abstract: A method for the conditioning of an extracorporeal device is described, as well as a method for extracorporeal extraction of toxic material from mammalian body fluids in connection with diagnosis or treatment of a mammalian condition or disease, in which methods reagents having the ability to extract toxic material from mammalian body fluids are involved, and an extracorporeal device comprising said reagent.

Abstract: A method and apparatus for feeding of strip material to a working machine in which the material is worked upon and separated into individual parts includes intermittent feeding of the strip material to working machines wherein the feed rate is controlled in relation to the speed of the working machine. The control of the feed rate is by a control system having a processor that is supplied with signals which correspond to the speed and position of the working machine and the feed rate and fed length of the material.

Abstract: The present invention is for a method and a means for feeding of strip material to working machine in which the material is worked upon and separated into individual parts. Primarily the invention is for feeding of metal strip to presses. At intermittent feeding of long objects (3) to working machines (2)the feed rate is controlled in relation to the speed of the working machine. The control of the feed rate is by means of a control system having a processor is supplied with signals which correspond to the speed and position of the working machine and the feed rate and fed length of the fed material (3).

Abstract: A method and a system is described for reducing non-target levels of specific molecules intended for diagnostic and/or therapeutic applications to vertebrate hosts, wherein said molecules are administered to a vertebrate host and kept therein for a certain time in order to be concentrate to the target by being attached thereto. The molecules which are not attached to the target are removed from the blood circulation system or at least reduced to a lower concentration by passing the blood through an extra-corporeal device.

Abstract: A transportation method of individual objects and a means for sorting each object into a receiver is disclosed. In accordance with the method, each object is individually picked from a conveyor and delivered to a selected collecting cassette, the objects being centered on the conveyor before being transferred to a pick-up device. The individual objects are delivered to the cassette with the pick-up device which turns 90 degrees and which tilts toward the selected cassette to deliver the object.The apparatus for handling of the individual objects includes a conveyor, a pick-up device mounted to a conveyor belt intended to pick-up and move the individual objects, and a device for centering each object before transference to the pick-up device. The pick-up device is turnable by 90 degrees in each direction, and is tiltable in the direction of the object.

Abstract: This invention concerns a device for checking the depth reached by operation of a digging machine including a digging implement (11) arranged on an arm (8) pivotably supported relative to the machine. The device comprises a fluid-filled conduit (13) associated with the arm (8) and extending between a location (14) thereon and a location (15) on the machine separated from the arm. The conduit is associated with a pressure sensor (17) for delivering information corresponding to the height of the fluid column between the locations. On the arm (8), there is provided, in addition to the first mentioned sensor (17), a second sensor (18) adapted to deliver information as to the inclination of the arm. In this way, the pressure sensor (17) may be provided at an arbitrary location on the arm 8.

Abstract: There is provided a measuring apparatus for successively and intermittently feeding one or more elongate workpieces (A) to a working machine. Between an attachment means (2) and a fixed clamping element (4) there is arranged a further clamping element (7) which is reciprocatingly movable along a pair of guides (6). As the movable clamping element (7) makes a working stroke, the workpiece (A) is able to pass freely through the fixed clamping element (4). Upon return movement of the movable clamping element (7), however, the workpiece is held by the fixed clamping element, with the movable clamping element (7) returning to its rearward limit position out of engagement with the workpiece. The movable clamping element (7) is connected, via a piston rod (10), to the piston (9) of a pneumatic cylinder (8) of variable volume, said cylinder having an end plate (11) which is displaceable therein.