Patents by Inventor Rung-Ywan Tsai
Rung-Ywan Tsai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10598658Abstract: A reduced graphene oxide-based biosensor includes a nano-structure field-effect transistor including a channel region which includes a reduced graphene oxide having a linking moiety to be bonded to a receptor specific to an analyte, and which is represented by a formula of —(C?O)—X—COOH, wherein X represents a C1-C3 alkenylene group or a C1-C3 alkylene group.Type: GrantFiled: November 16, 2015Date of Patent: March 24, 2020Assignee: Chang Gung UniversityInventors: Mu-Yi Hua, Hsiao-Chien Chen, Yi-Ting Chen, Rung-Ywan Tsai, Min-Cheng Chen, Chien-Lun Chen
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Patent number: 10520436Abstract: An optical scanning system adapted to scan a sample on a chip is provided. The optical scanning system includes at least one optical scanning head, at least one scanning light source, a light receiving device and a processor. Each of at least one optical scanning head includes a focusing light source, a first optical guiding structure, and a control unit. The first optical guiding structure is configured to guide the focusing light emitted from the focusing light source to travel to the sample, and the first optical guiding structure is configured to guide the at least one scanning light emitted from the at least one scanning light source to the sample to generate a secondary light. The control unit is configured to control the first optical guiding structure to keep the focusing light and at least one scanning light focusing on a surface of the chip. The light receiving device receives the secondary light and generates a scanning electronic signal.Type: GrantFiled: February 24, 2017Date of Patent: December 31, 2019Assignee: Caduceus Biotechnology Inc.Inventors: Golden Tiao, Jung-Po Chen, Chien-Chung Pien, Tsung-Kai Chang, Feng-Hsiang Lo, Jean-Dow Lee, Jinn-Cherng Yang, Rung-Ywan Tsai
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Patent number: 9995683Abstract: An apparatus for detecting an object capable of emitting light. The apparatus includes a light source and a waveguide. The waveguide includes a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further includes a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.Type: GrantFiled: June 18, 2014Date of Patent: June 12, 2018Assignee: Industrial Technology Research InstituteInventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu
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Publication number: 20180149611Abstract: A biosensors and a method of forming a probe on a solid surface of a biosensor are disclosed and the method includes the following steps. A unit (a nucleotide or an amino acid) capped with a protecting group is covalently bonded on the solid surface of one of a plurality of sensor cells of the biosensor. At least one cycle of the following steps is performed until a desired number of units is formed: irradiating the one of the plurality of sensor cells, so as to remove the protecting group of the unit; and binding a unit capped with the protecting group to the de-protected unit. The one of the plurality of sensor cells is irradiated to remove the protecting group.Type: ApplicationFiled: November 28, 2017Publication date: May 31, 2018Applicants: Caduceus Biotechnology Inc., HELIOS BIOELECTRONICS INC.Inventors: Golden Tiao, Rung-Ywan Tsai, Wen-Yih Chen
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Publication number: 20180149594Abstract: An optical scanning system adapted to scan a sample on a chip is provided. The optical scanning system includes at least one optical scanning head, at least one scanning light source, a light receiving device and a processor. Each of at least one optical scanning head includes a focusing light source, a first optical guiding structure, and a control unit. The first optical guiding structure is configured to guide the focusing light emitted from the focusing light source to travel to the sample, and the first optical guiding structure is configured to guide the at least one scanning light emitted from the at least one scanning light source to the sample to generate a secondary light. The control unit is configured to control the first optical guiding structure to keep the focusing light and at least one scanning light focusing on a surface of the chip. The light receiving device receives the secondary light and generates a scanning electronic signal.Type: ApplicationFiled: February 24, 2017Publication date: May 31, 2018Applicant: Caduceus Biotechnology Inc.Inventors: Golden Tiao, Jung-Po Chen, Chien-Chung Pien, Tsung-Kai Chang, Feng-Hsiang Lo, Jean-Dow Lee, Jinn-Cherng Yang, Rung-Ywan Tsai
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Publication number: 20160334399Abstract: A reduced graphene oxide-based biosensor includes a nano-structure field-effect transistor including a channel region which includes a reduced graphene oxide having a linking moiety to be bonded to a receptor specific to an analyte, and which is represented by a formula of —(C?O)—X—COOH, wherein X represents a C1-C3 alkenylene group or a C1-C3 alkylene group.Type: ApplicationFiled: November 16, 2015Publication date: November 17, 2016Inventors: Mu-Yi Hua, Hsiao-Chien Chen, Yi-Ting Chen, Rung-Ywan Tsai, Min-Cheng Chen, Chien-Lun Chen
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Patent number: 9181167Abstract: A chemically-modified graphene includes a graphene layer and a plurality of functional groups that are grafted to the graphene layer and each of which is represented by —CO—R—COOH, wherein R is an optionally substituted C1-C5 alkylene group or an optionally substituted C1-C5 alkenylene group. A method for producing a chemically-modified grapheme includes subjecting a cyclic anhydride and graphite to a Friedel-Crafts reaction in the presence of a Lewis acid.Type: GrantFiled: September 14, 2012Date of Patent: November 10, 2015Assignee: Chang Gung UniversityInventors: Mu-Yi Hua, Shi-Liang Chen, Hsiao-Chien Chen, Rung-Ywan Tsai, Wu-Shiung Feng, Ming-Jer Jeng
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Patent number: 9117149Abstract: A carrier with the optical registration function is disclosed. The carrier allows the registration of inspected results of the sampling images of the sample to the corresponding address codes of the address coding site of the carrier.Type: GrantFiled: July 21, 2013Date of Patent: August 25, 2015Assignee: Industrial Technology Research InstituteInventors: Kuo-Tung Tiao, Sheng-Li Chang, Jung-Po Chen, Chun-Chieh Huang, Jyh-Chern Chen, Rung-Ywan Tsai, Tai-Ting Huang, Yuan-Chin Lee, Feng-Hsiang Lo, Lung-Pin Chung, Hung-Chih Chiang, Kuo-Yao Weng
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Patent number: 8992990Abstract: The present invention discloses a magnetic nanocomposite for inhibiting/treating cancer and a method for fabricating the same. The magnetic nanocomposite comprises a core formed of a plurality of magnetic nanoparticles made of ferric ferrous oxide (Fe3O4); a shell made of a carboxy-functionalized polyaniline; and an anti-tumor medicine bound to the external surface of the shell. The method of the present invention fast fabricates the magnetic nanocomposite in a simple way. The medicine of the present invention has a longer half life and a better thermal stability. The present invention disperses the water-insoluble medicine in water uniformly to decrease the biological rejection. Moreover, the magnetic nanocomposite of the present invention is guided to the nidus by an external magnetic field to increase the local concentration of the medicine and provide an effective chemotherapy. Therefore, the present invention has competitive advantage over the conventional BCNU.Type: GrantFiled: May 4, 2010Date of Patent: March 31, 2015Assignee: Chang Gung UniversityInventors: Mu-Yi Hua, Hung-Wei Yang, Rung-Ywan Tsai, Kuo-Chen Wei, Pin-Yuan Chen, Chiung-Yin Huang
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Patent number: 8974769Abstract: The present invention proposes a magnetic nanocomposite with multi-biofunctional groups, which comprises a core and a shell wrapping the core, wherein the core contains magnetic nanoparticles, and wherein the shell is made of a conductive polymer with multi-biofunctional groups where a medicine, an antibody or a fluorescent label can be attached.Type: GrantFiled: May 4, 2010Date of Patent: March 10, 2015Assignee: Chang Gung UniversityInventors: Mu-Yi Hua, Hung-Wei Yang, Rung-Ywan Tsai, Kuo-Chen Wei, Pin-Yuan Chen, Hao-Li Liu
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Publication number: 20140367589Abstract: An apparatus for detecting an object capable of emitting light. The apparatus includes a light source and a waveguide. The waveguide includes a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further includes a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.Type: ApplicationFiled: June 18, 2014Publication date: December 18, 2014Inventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu
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Patent number: 8894206Abstract: A diagnostic equipment having an auto-focusing function comprising a image detection device, a first scanning device, a mobile optical lens assembly, a focusing detection device and a first splitter assembly is provided. The image detection device comprises a first light source and a first photo detector. The first light source provides a first incident light and the first incident light incident to an object and becomes a first signal light. The first photo detector is for receiving the first signal light. The first scanning device is for adjusting a path of the first incident light and to scan the object. The mobile optical lens assembly has a lens and a mobile platform. The first splitter assembly is for transmitting the first and the second signal light to the first and the second photo detector, respectively.Type: GrantFiled: December 27, 2012Date of Patent: November 25, 2014Assignee: Industrial Technology Research InstituteInventors: Yuan-Chin Lee, Rung-Ywan Tsai, Chi-Shen Chang, Tai-Ting Huang, Hung-Yueh Chen, Hong-Chou Lyu
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Patent number: 8889192Abstract: The present invention discloses a magnetic nanomedicine for inhibiting/treating human prostate cancer, which comprises a core containing a magnetic particle having a diameter of less than 10 nm; a shell made of a carboxylated polyaniline and encapsulating the core; and a medicine covalently linked to the shell and able to inhibit/treat prostate cancer. The magnetic nanomedicine of the present invention not only has superior thermal stability and but also has water solubility higher than that of the conventional anti-prostate cancer medicine. Further, the magnetic nanomedicine of the present invention can be magnetically conducted to the cancer area to increase the local concentration of medicine and enhance the therapeutic effect.Type: GrantFiled: July 6, 2011Date of Patent: November 18, 2014Assignee: Chang Gung UniversityInventors: Mu-Yi Hua, Hung-Wei Yang, Cheng-Keng Chuang, See-Tong Pang, Hao-Li Liu, Rung-Ywan Tsai, Kun-Lung Chuang
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Patent number: 8873034Abstract: A fiber-type image capturing apparatus includes a fiber optic, an optical rotating module, an outer tube, an air inlet hole, and an air outlet hole. The optical rotating module is connected to one end of the fiber optic and has a light forward exit and a light lateral exit. The optical rotating module further includes a stator, a rotor, and a light path selector. The stator is fixed correspondingly to the fiber optic. The rotor has a fan blade which is pivotally connected to the stator. The light path selector is installed at the rotor and has a forward scanning path and a lateral scanning path. The outer tube fixes the fiber optic and the optical rotating module. The air inlet hole is disposed at the outer tube and feeds the fan blade with air. The air outlet hole is disposed at the outer tube and vents the air.Type: GrantFiled: March 18, 2013Date of Patent: October 28, 2014Assignees: China Medical University, Industrial Technology Research InstituteInventors: Shinn-Zong Lin, Horng-Jyh Harn, Rung-Ywan Tsai, Yuan-Chin Lee
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Patent number: 8865077Abstract: An apparatus for detecting an object capable of emitting light. The apparatus comprises a light source and a waveguide. The waveguide comprises a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further comprises a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.Type: GrantFiled: June 11, 2010Date of Patent: October 21, 2014Assignee: Industrial Technology Research InstituteInventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu
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Patent number: 8865078Abstract: An apparatus for detecting an object capable of emitting light. The apparatus includes a light source and a waveguide. The waveguide includes a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further includes a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.Type: GrantFiled: July 29, 2010Date of Patent: October 21, 2014Assignee: Industrial Technology Research InstituteInventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu
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Patent number: 8858767Abstract: This invention is directed to a polyamic acid represented by the following formula (I), and an electrode having an active layer made from the polyamic acid of formula (I).Type: GrantFiled: April 12, 2012Date of Patent: October 14, 2014Assignee: Chang Gung UniversityInventors: Mu-Yi Hua, Yaw-Terng Chern, Hsiao-Chien Chen, Rung-Ywan Tsai
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Patent number: 8816249Abstract: An apparatus for fabricating patterns using a laser diode is presented. The apparatus includes at least one laser diode, at least one lens and a mask having at least one pin hole, wherein light emitted from the laser diode is emitted through the lens and the pin hole to be focused on a first material layer.Type: GrantFiled: April 27, 2011Date of Patent: August 26, 2014Assignee: Industrial Technology Research InstituteInventors: Ying-Chi Chen, Rung-Ywan Tsai, Golden Tiao
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Publication number: 20140168654Abstract: A fiber-type image capturing apparatus includes a fiber optic, an optical rotating module, an outer tube, an air inlet hole, and an air outlet hole. The optical rotating module is connected to one end of the fiber optic and has a light forward exit and a light lateral exit. The optical rotating module further includes a stator, a rotor, and a light path selector. The stator is fixed correspondingly to the fiber optic. The rotor has a fan blade which is pivotally connected to the stator. The light path selector is installed at the rotor and has a forward scanning path and a lateral scanning path. The outer tube fixes the fiber optic and the optical rotating module. The air inlet hole is disposed at the outer tube and feeds the fan blade with air. The air outlet hole is disposed at the outer tube and vents the air.Type: ApplicationFiled: March 18, 2013Publication date: June 19, 2014Applicants: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE, CHINA MEDICAL UNIVERSITYInventors: Shinn-Zong LIN, Horng-Jyh HARN, Rung-Ywan TSAI, Yuan-Chin LEE
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Patent number: 8721969Abstract: An apparatus for detecting an object capable of emitting light. The apparatus comprises a light source and a waveguide. The waveguide comprises a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further comprises a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.Type: GrantFiled: June 11, 2010Date of Patent: May 13, 2014Assignee: Industrial Technology Research InstituteInventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu