Patents by Inventor Rung-Ywan Tsai

Rung-Ywan Tsai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10598658
    Abstract: A reduced graphene oxide-based biosensor includes a nano-structure field-effect transistor including a channel region which includes a reduced graphene oxide having a linking moiety to be bonded to a receptor specific to an analyte, and which is represented by a formula of —(C?O)—X—COOH, wherein X represents a C1-C3 alkenylene group or a C1-C3 alkylene group.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: March 24, 2020
    Assignee: Chang Gung University
    Inventors: Mu-Yi Hua, Hsiao-Chien Chen, Yi-Ting Chen, Rung-Ywan Tsai, Min-Cheng Chen, Chien-Lun Chen
  • Patent number: 10520436
    Abstract: An optical scanning system adapted to scan a sample on a chip is provided. The optical scanning system includes at least one optical scanning head, at least one scanning light source, a light receiving device and a processor. Each of at least one optical scanning head includes a focusing light source, a first optical guiding structure, and a control unit. The first optical guiding structure is configured to guide the focusing light emitted from the focusing light source to travel to the sample, and the first optical guiding structure is configured to guide the at least one scanning light emitted from the at least one scanning light source to the sample to generate a secondary light. The control unit is configured to control the first optical guiding structure to keep the focusing light and at least one scanning light focusing on a surface of the chip. The light receiving device receives the secondary light and generates a scanning electronic signal.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: December 31, 2019
    Assignee: Caduceus Biotechnology Inc.
    Inventors: Golden Tiao, Jung-Po Chen, Chien-Chung Pien, Tsung-Kai Chang, Feng-Hsiang Lo, Jean-Dow Lee, Jinn-Cherng Yang, Rung-Ywan Tsai
  • Patent number: 9995683
    Abstract: An apparatus for detecting an object capable of emitting light. The apparatus includes a light source and a waveguide. The waveguide includes a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further includes a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: June 12, 2018
    Assignee: Industrial Technology Research Institute
    Inventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu
  • Publication number: 20180149611
    Abstract: A biosensors and a method of forming a probe on a solid surface of a biosensor are disclosed and the method includes the following steps. A unit (a nucleotide or an amino acid) capped with a protecting group is covalently bonded on the solid surface of one of a plurality of sensor cells of the biosensor. At least one cycle of the following steps is performed until a desired number of units is formed: irradiating the one of the plurality of sensor cells, so as to remove the protecting group of the unit; and binding a unit capped with the protecting group to the de-protected unit. The one of the plurality of sensor cells is irradiated to remove the protecting group.
    Type: Application
    Filed: November 28, 2017
    Publication date: May 31, 2018
    Applicants: Caduceus Biotechnology Inc., HELIOS BIOELECTRONICS INC.
    Inventors: Golden Tiao, Rung-Ywan Tsai, Wen-Yih Chen
  • Publication number: 20180149594
    Abstract: An optical scanning system adapted to scan a sample on a chip is provided. The optical scanning system includes at least one optical scanning head, at least one scanning light source, a light receiving device and a processor. Each of at least one optical scanning head includes a focusing light source, a first optical guiding structure, and a control unit. The first optical guiding structure is configured to guide the focusing light emitted from the focusing light source to travel to the sample, and the first optical guiding structure is configured to guide the at least one scanning light emitted from the at least one scanning light source to the sample to generate a secondary light. The control unit is configured to control the first optical guiding structure to keep the focusing light and at least one scanning light focusing on a surface of the chip. The light receiving device receives the secondary light and generates a scanning electronic signal.
    Type: Application
    Filed: February 24, 2017
    Publication date: May 31, 2018
    Applicant: Caduceus Biotechnology Inc.
    Inventors: Golden Tiao, Jung-Po Chen, Chien-Chung Pien, Tsung-Kai Chang, Feng-Hsiang Lo, Jean-Dow Lee, Jinn-Cherng Yang, Rung-Ywan Tsai
  • Publication number: 20160334399
    Abstract: A reduced graphene oxide-based biosensor includes a nano-structure field-effect transistor including a channel region which includes a reduced graphene oxide having a linking moiety to be bonded to a receptor specific to an analyte, and which is represented by a formula of —(C?O)—X—COOH, wherein X represents a C1-C3 alkenylene group or a C1-C3 alkylene group.
    Type: Application
    Filed: November 16, 2015
    Publication date: November 17, 2016
    Inventors: Mu-Yi Hua, Hsiao-Chien Chen, Yi-Ting Chen, Rung-Ywan Tsai, Min-Cheng Chen, Chien-Lun Chen
  • Patent number: 9181167
    Abstract: A chemically-modified graphene includes a graphene layer and a plurality of functional groups that are grafted to the graphene layer and each of which is represented by —CO—R—COOH, wherein R is an optionally substituted C1-C5 alkylene group or an optionally substituted C1-C5 alkenylene group. A method for producing a chemically-modified grapheme includes subjecting a cyclic anhydride and graphite to a Friedel-Crafts reaction in the presence of a Lewis acid.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: November 10, 2015
    Assignee: Chang Gung University
    Inventors: Mu-Yi Hua, Shi-Liang Chen, Hsiao-Chien Chen, Rung-Ywan Tsai, Wu-Shiung Feng, Ming-Jer Jeng
  • Patent number: 9117149
    Abstract: A carrier with the optical registration function is disclosed. The carrier allows the registration of inspected results of the sampling images of the sample to the corresponding address codes of the address coding site of the carrier.
    Type: Grant
    Filed: July 21, 2013
    Date of Patent: August 25, 2015
    Assignee: Industrial Technology Research Institute
    Inventors: Kuo-Tung Tiao, Sheng-Li Chang, Jung-Po Chen, Chun-Chieh Huang, Jyh-Chern Chen, Rung-Ywan Tsai, Tai-Ting Huang, Yuan-Chin Lee, Feng-Hsiang Lo, Lung-Pin Chung, Hung-Chih Chiang, Kuo-Yao Weng
  • Patent number: 8992990
    Abstract: The present invention discloses a magnetic nanocomposite for inhibiting/treating cancer and a method for fabricating the same. The magnetic nanocomposite comprises a core formed of a plurality of magnetic nanoparticles made of ferric ferrous oxide (Fe3O4); a shell made of a carboxy-functionalized polyaniline; and an anti-tumor medicine bound to the external surface of the shell. The method of the present invention fast fabricates the magnetic nanocomposite in a simple way. The medicine of the present invention has a longer half life and a better thermal stability. The present invention disperses the water-insoluble medicine in water uniformly to decrease the biological rejection. Moreover, the magnetic nanocomposite of the present invention is guided to the nidus by an external magnetic field to increase the local concentration of the medicine and provide an effective chemotherapy. Therefore, the present invention has competitive advantage over the conventional BCNU.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: March 31, 2015
    Assignee: Chang Gung University
    Inventors: Mu-Yi Hua, Hung-Wei Yang, Rung-Ywan Tsai, Kuo-Chen Wei, Pin-Yuan Chen, Chiung-Yin Huang
  • Patent number: 8974769
    Abstract: The present invention proposes a magnetic nanocomposite with multi-biofunctional groups, which comprises a core and a shell wrapping the core, wherein the core contains magnetic nanoparticles, and wherein the shell is made of a conductive polymer with multi-biofunctional groups where a medicine, an antibody or a fluorescent label can be attached.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: March 10, 2015
    Assignee: Chang Gung University
    Inventors: Mu-Yi Hua, Hung-Wei Yang, Rung-Ywan Tsai, Kuo-Chen Wei, Pin-Yuan Chen, Hao-Li Liu
  • Publication number: 20140367589
    Abstract: An apparatus for detecting an object capable of emitting light. The apparatus includes a light source and a waveguide. The waveguide includes a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further includes a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.
    Type: Application
    Filed: June 18, 2014
    Publication date: December 18, 2014
    Inventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu
  • Patent number: 8894206
    Abstract: A diagnostic equipment having an auto-focusing function comprising a image detection device, a first scanning device, a mobile optical lens assembly, a focusing detection device and a first splitter assembly is provided. The image detection device comprises a first light source and a first photo detector. The first light source provides a first incident light and the first incident light incident to an object and becomes a first signal light. The first photo detector is for receiving the first signal light. The first scanning device is for adjusting a path of the first incident light and to scan the object. The mobile optical lens assembly has a lens and a mobile platform. The first splitter assembly is for transmitting the first and the second signal light to the first and the second photo detector, respectively.
    Type: Grant
    Filed: December 27, 2012
    Date of Patent: November 25, 2014
    Assignee: Industrial Technology Research Institute
    Inventors: Yuan-Chin Lee, Rung-Ywan Tsai, Chi-Shen Chang, Tai-Ting Huang, Hung-Yueh Chen, Hong-Chou Lyu
  • Patent number: 8889192
    Abstract: The present invention discloses a magnetic nanomedicine for inhibiting/treating human prostate cancer, which comprises a core containing a magnetic particle having a diameter of less than 10 nm; a shell made of a carboxylated polyaniline and encapsulating the core; and a medicine covalently linked to the shell and able to inhibit/treat prostate cancer. The magnetic nanomedicine of the present invention not only has superior thermal stability and but also has water solubility higher than that of the conventional anti-prostate cancer medicine. Further, the magnetic nanomedicine of the present invention can be magnetically conducted to the cancer area to increase the local concentration of medicine and enhance the therapeutic effect.
    Type: Grant
    Filed: July 6, 2011
    Date of Patent: November 18, 2014
    Assignee: Chang Gung University
    Inventors: Mu-Yi Hua, Hung-Wei Yang, Cheng-Keng Chuang, See-Tong Pang, Hao-Li Liu, Rung-Ywan Tsai, Kun-Lung Chuang
  • Patent number: 8873034
    Abstract: A fiber-type image capturing apparatus includes a fiber optic, an optical rotating module, an outer tube, an air inlet hole, and an air outlet hole. The optical rotating module is connected to one end of the fiber optic and has a light forward exit and a light lateral exit. The optical rotating module further includes a stator, a rotor, and a light path selector. The stator is fixed correspondingly to the fiber optic. The rotor has a fan blade which is pivotally connected to the stator. The light path selector is installed at the rotor and has a forward scanning path and a lateral scanning path. The outer tube fixes the fiber optic and the optical rotating module. The air inlet hole is disposed at the outer tube and feeds the fan blade with air. The air outlet hole is disposed at the outer tube and vents the air.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: October 28, 2014
    Assignees: China Medical University, Industrial Technology Research Institute
    Inventors: Shinn-Zong Lin, Horng-Jyh Harn, Rung-Ywan Tsai, Yuan-Chin Lee
  • Patent number: 8865077
    Abstract: An apparatus for detecting an object capable of emitting light. The apparatus comprises a light source and a waveguide. The waveguide comprises a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further comprises a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: October 21, 2014
    Assignee: Industrial Technology Research Institute
    Inventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu
  • Patent number: 8865078
    Abstract: An apparatus for detecting an object capable of emitting light. The apparatus includes a light source and a waveguide. The waveguide includes a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further includes a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.
    Type: Grant
    Filed: July 29, 2010
    Date of Patent: October 21, 2014
    Assignee: Industrial Technology Research Institute
    Inventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu
  • Patent number: 8858767
    Abstract: This invention is directed to a polyamic acid represented by the following formula (I), and an electrode having an active layer made from the polyamic acid of formula (I).
    Type: Grant
    Filed: April 12, 2012
    Date of Patent: October 14, 2014
    Assignee: Chang Gung University
    Inventors: Mu-Yi Hua, Yaw-Terng Chern, Hsiao-Chien Chen, Rung-Ywan Tsai
  • Patent number: 8816249
    Abstract: An apparatus for fabricating patterns using a laser diode is presented. The apparatus includes at least one laser diode, at least one lens and a mask having at least one pin hole, wherein light emitted from the laser diode is emitted through the lens and the pin hole to be focused on a first material layer.
    Type: Grant
    Filed: April 27, 2011
    Date of Patent: August 26, 2014
    Assignee: Industrial Technology Research Institute
    Inventors: Ying-Chi Chen, Rung-Ywan Tsai, Golden Tiao
  • Publication number: 20140168654
    Abstract: A fiber-type image capturing apparatus includes a fiber optic, an optical rotating module, an outer tube, an air inlet hole, and an air outlet hole. The optical rotating module is connected to one end of the fiber optic and has a light forward exit and a light lateral exit. The optical rotating module further includes a stator, a rotor, and a light path selector. The stator is fixed correspondingly to the fiber optic. The rotor has a fan blade which is pivotally connected to the stator. The light path selector is installed at the rotor and has a forward scanning path and a lateral scanning path. The outer tube fixes the fiber optic and the optical rotating module. The air inlet hole is disposed at the outer tube and feeds the fan blade with air. The air outlet hole is disposed at the outer tube and vents the air.
    Type: Application
    Filed: March 18, 2013
    Publication date: June 19, 2014
    Applicants: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE, CHINA MEDICAL UNIVERSITY
    Inventors: Shinn-Zong LIN, Horng-Jyh HARN, Rung-Ywan TSAI, Yuan-Chin LEE
  • Patent number: 8721969
    Abstract: An apparatus for detecting an object capable of emitting light. The apparatus comprises a light source and a waveguide. The waveguide comprises a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further comprises a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: May 13, 2014
    Assignee: Industrial Technology Research Institute
    Inventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu