Abstract: The present disclosure provides a flexible job-shop scheduling method and system and an electronic device. The method according to the present disclosure includes: randomly generating a plurality of flexible job-shop environments in a production job-shop according to a preset production target; constructing a scheduling strategy model of the production job-shop based on a Markov decision process; optimizing a feature extraction network, an actor network and a critic network simultaneously by using the scheduling strategy model and a plurality of data sets, and determining a scheduling plan corresponding to a maximum completion time as an optimal scheduling plan after the completion of the optimization; and completing the preset production target based on the optimal scheduling plan. According to the present disclosure, feature extraction is performed on the plurality of job-shop environments to generate a scheduling scheme, so as to improve the efficiency and rationality of flexible job-shop scheduling.

Abstract: Cycloalkyl and hetero-cycloalkyl inhibitors, preparation methods therefor, and the use thereof are described. Compounds of the present invention have a structure represented by formula (I). Further disclosed are preparation methods for said compounds, and the use of said compounds as KRASG12C inhibitors. The compounds have an excellent ability to selectively inhibit KRASG12C, improved pharmacodynamic and pharmacokinetic performance, and reduced toxic side effects.

Abstract: Cycloalkyl and hetero-cycloalkyl inhibitors, preparation methods therefor, and the use thereof are described. Compounds of the present invention have a structure represented by formula (I). Further disclosed are preparation methods for said compounds, and the use of said compounds as KRASG12C inhibitors. The compounds have an excellent ability to selectively inhibit KRASG12C, improved pharmacodynamic and pharmacokinetic performance, and reduced toxic side effects.