Patents by Inventor Runsheng Li

Runsheng Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12215150
    Abstract: Provided are antibodies or fragment thereof having binding specificity to the human solute carrier 34 A2 (SLC34A2) protein. These antibodies are capable of binding to SLC34A2 at high affinity and can mediate antibody-dependent cellular cytotoxicity (ADCC) and effectively induce endocytosis. Also provided are methods and uses for treating cancers.
    Type: Grant
    Filed: May 6, 2024
    Date of Patent: February 4, 2025
    Assignee: LANOVA MEDICINES DEVELOPMENT CO., LTD.
    Inventors: Runsheng Li, Wentao Huang, Yifan Li
  • Publication number: 20250019442
    Abstract: Provided are bispecific antibodies capable of binding to human VEGF protein and human PD-1 protein. These bispecific antibodies are effective in treating cancer.
    Type: Application
    Filed: September 26, 2024
    Publication date: January 16, 2025
    Inventors: Runsheng Li, Wei CAO, Haijuan GU, Wentao HUANG, Ying Qin ZANG
  • Patent number: 12194106
    Abstract: Provided are antibodies and fragments thereof having binding specificity to the liver receptor homolog 1 (LIV-1. SLC39A6 or ZIP6) protein as well as their derivatives and uses.
    Type: Grant
    Filed: May 6, 2024
    Date of Patent: January 14, 2025
    Assignee: LANOVA MEDICINES LIMITED
    Inventors: Runsheng Li, Wentao Huang, Ying Qin Zang, Zhifang Liu, Yifan Li
  • Publication number: 20250011419
    Abstract: Provided are antibodies or fragment thereof having binding specificity to the wild-type human claudin 18.2 (CLDN18.2) protein and also capable of binding the M149L mutant. By contrast, such antibodies and fragments do not or weakly bind to claudin 18.1 (CLDN18.1).
    Type: Application
    Filed: June 24, 2024
    Publication date: January 9, 2025
    Inventor: Runsheng Li
  • Patent number: 12180276
    Abstract: Provided are antibodies and fragments thereof having binding specificity to the claudin 6 (CLDN6) protein as well as their derivatives and uses.
    Type: Grant
    Filed: May 6, 2024
    Date of Patent: December 31, 2024
    Assignee: LANOVA MEDICINES LIMITED
    Inventors: Runsheng Li, Wentao Huang, Ying Qin Zang, Zhifang Liu
  • Publication number: 20240400701
    Abstract: Provided are anti-AMHRII antibodies and antigen-binding fragments, as well as their bispecific or multispecific counterparts. Methods of using the antibodies for treating and diagnosing diseases such as cancer are also provided.
    Type: Application
    Filed: October 8, 2022
    Publication date: December 5, 2024
    Inventors: Runsheng LI, Wentao HUANG, Yifan LI
  • Publication number: 20240383993
    Abstract: Provided are anti-4-1BB nanobodies and bispecific or multispecific antibodies that incorporate the nanobodies. Methods of using the antibodies for treating and diagnosing diseases such as cancer are also provided.
    Type: Application
    Filed: August 29, 2022
    Publication date: November 21, 2024
    Inventors: Runsheng LI, Wentao HUANG
  • Publication number: 20240325555
    Abstract: Provided are antibodies and fragments thereof having binding specificity to the liver receptor homolog 1 (LIV-1, SLC39A6 or ZIP6) protein as well as their derivatives and uses.
    Type: Application
    Filed: May 6, 2024
    Publication date: October 3, 2024
    Inventors: Runsheng Li, Wentao Huang, Ying Qin Zang, Zhifang LIU, Yifan Li
  • Publication number: 20240317851
    Abstract: Provided are antibodies and fragments thereof having binding specificity to the claudin 6 (CLDN6) protein as well as their derivatives and uses.
    Type: Application
    Filed: May 6, 2024
    Publication date: September 26, 2024
    Inventors: Runsheng Li, Wentao Huang, Ying Qin Zang, Zhifang LIU
  • Publication number: 20240301052
    Abstract: Provided are antibodies or fragment thereof having binding specificity to the human solute carrier 34 A2 (SLC34A2) protein. These antibodies are capable of binding to SLC34A2 at high affinity and can mediate antibody-dependent cellular cytotoxicity (ADCC) and effectively induce endocytosis. Also provided are methods and uses for treating cancers.
    Type: Application
    Filed: May 6, 2024
    Publication date: September 12, 2024
    Inventors: Runsheng Li, Wentao Huang, Yifan Li
  • Publication number: 20240294656
    Abstract: Provided are bispecific or multispecific antibodies that include an anti-CEACAM5 portion and one or more anti-4-1BB nanobodies whose agonist activity is dependent on the presence of the CEACAM5 antigen. Such bispecific or multispecific antibodies are safe, and are efficacious in treating cancer and have long-term protective immunological memory against tumors. Methods of using the antibodies for treating diseases such as cancer are also provided.
    Type: Application
    Filed: May 8, 2024
    Publication date: September 5, 2024
    Inventors: Runsheng Li, Wei Cao, Ying Qin Zang, Wentao Huang
  • Publication number: 20240262841
    Abstract: The present disclosure relates to anticancer compounds, including, but not limited to, antibody-drug conjugates using the same, which compounds and ACDs thereof are suitable for the treatment of cancer.
    Type: Application
    Filed: February 6, 2024
    Publication date: August 8, 2024
    Inventors: Runsheng LI, Wentao HUANG, Zhifang LIU, Ying Qin ZANG
  • Patent number: 12018076
    Abstract: Provided are antibodies or fragment thereof having binding specificity to the wild-type human claudin 18.2 (CLDN18.2) protein and also capable of binding the M149L mutant. By contrast, such antibodies and fragments do not or weakly bind to claudin 18.1 (CLDN18.1).
    Type: Grant
    Filed: August 5, 2021
    Date of Patent: June 25, 2024
    Assignee: LaNova Medicines Limited Company
    Inventor: Runsheng Li
  • Publication number: 20240141052
    Abstract: Provided are antibodies or fragment thereof having binding specificity to the human chemokine (C-C motif) receptor 8 (CCR8) protein. These antibodies are capable of binding to CCR8 at high affinity and can mediate antibody-dependent cellular cytotoxicity (ADCC).
    Type: Application
    Filed: December 15, 2023
    Publication date: May 2, 2024
    Inventors: Runsheng Li, Wentao Huang
  • Publication number: 20240101716
    Abstract: Provided are antibodies and fragments having binding specificity to the signal regulatory protein alpha (SIRP?) protein and to the programmed death-ligand 1 (PD-L1) protein. The antibodies and fragments can bring peripheral macrophages to PD-L1+ tumor site, thereby enhancing tumor treatment.
    Type: Application
    Filed: December 17, 2021
    Publication date: March 28, 2024
    Inventors: Runsheng LI, Ying Qin ZANG
  • Patent number: 11873342
    Abstract: Provided are antibodies or fragment thereof having binding specificity to the human chemokine (C—C motif) receptor 8 (CCR8) protein. These antibodies are capable of binding to CCR8 at high affinity and can mediate antibody-dependent cellular cytotoxicity (ADCC).
    Type: Grant
    Filed: March 2, 2022
    Date of Patent: January 16, 2024
    Assignee: LaNova Medicines Limited
    Inventors: Runsheng Li, Wentao Huang
  • Publication number: 20230330253
    Abstract: Provided are antibody-drug conjugates containing a drug moiety attached to an antibody or fragment thereof having binding specificity to the wild-type human claudin 18.2 (CLDN18.2) protein. The antibody or the fragment thereof binds to the ?3-?4 loop (residues 45-63 of SEQ ID NO: 30, NYQGLWRSCVRESSGFTEC) and the ?5 strand (residues 169-172 of SEQ ID NO: 30, YTFG) of CLDN18.2.
    Type: Application
    Filed: December 13, 2022
    Publication date: October 19, 2023
    Inventor: RunSheng LI
  • Publication number: 20230203160
    Abstract: Provided are chimeric antigen receptors that include an antibody or fragment thereof having binding specificity to the human GPRC5D protein. The chimeric antigen receptors and immune cells expressing the chimeric antigen receptors are capable of targeting cancer cells expressing GPRC5D, and thus can be used to treat the cancer, in particular hematological cancer.
    Type: Application
    Filed: July 7, 2022
    Publication date: June 29, 2023
    Inventors: Runsheng Li, Wentao Huang
  • Publication number: 20230072565
    Abstract: Wire arc additive manufacturing-spinning combined machining device and method are provided. The machining device includes a spinning mechanism and a fused deposition modeling mechanism. The spinning mechanism includes a machine tool and a spinning head. The spinning head is installed on the machine tool by a main shaft, and the main shaft is configured to drive the spinning head to rotate to achieve the movement in three vertical directions. The spinning head includes a spinning base and balls. Each of the balls is installed in a corresponding one of arc grooves at a bottom of the spinning base. The fused deposition modeling mechanism includes a moving track, a robot and a heat source generator. The arc moving track is arranged around the machine tool in a surrounding mode. The robot is movably installed on the moving track. The heat source generator is installed at a tail end of the robot.
    Type: Application
    Filed: August 31, 2022
    Publication date: March 9, 2023
    Inventors: Hai'ou Zhang, Kai Wang, Fusheng Dai, Xushan Zhao, Runsheng Li, Jun Wu, Haitao Yang, Huayu Zhang
  • Patent number: 11554177
    Abstract: Provided are antibody-drug conjugates containing a drug moiety attached to an antibody or fragment thereof having binding specificity to the wild-type human claudin 18.2 (CLDN18.2) protein. The antibody or the fragment thereof binds to the ?3-?4 loop (residues 45-63 of SEQ ID NO: 30, NYQGLWRSCVRESSGFTEC) and the ?5 strand (residues 169-172 of SEQ ID NO: 30, YTFG) of CLDN18.2.
    Type: Grant
    Filed: November 18, 2021
    Date of Patent: January 17, 2023
    Assignee: Lanova Medicines Limited Company
    Inventor: RunSheng Li