Patents by Inventor Runwei YANG

Runwei YANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SPLICE-SWITCHING OLIGONUCLEOTIDES FOR TREATING SYNGAP1-ASSOCIATED DISORDERS
    Publication number: 20260218181
    Abstract: Aspects of the disclosure relate to the discovery that antisense oligonucleotides (ASOs) that bind to a single regions of a SYNGAP1 pre-mRNA to block alternative splicing lead to an efficient increase of protein produced from matured SYNGAP1 pre-mRNA. This increase can alleviate issues related to loss-of-function mutations in the SYNGAP1 gene, including those that lead to haploinsufficiencies. Alleviating such issues can be useful to treat neurological disorders that result from such mutations.
    Type: Application
    Filed: December 28, 2023
    Publication date: July 30, 2026
    Applicant: THE UNIVERSITY OF CHICAGO
    Inventors: Xiaochang ZHANG, Runwei YANG