Patents by Inventor Ruochen Jia

Ruochen Jia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds targeting mutant calreticulin
    Patent number: 12410185
    Abstract: The present invention relates to compounds binding to calreticulin which selectively inhibit growth of CALR mutant cells and/or exhibit selective cytotoxicity towards CALR mutant cells, to pharmaceutical compositions comprising such compounds as well as to their use in treating diseases or conditions caused by or associated with a mutation of CALR, in particular myeloid malignancies, such as myeloproliferative neoplasms or myelodysplasia syndrome. The present invention also relates to screening assays allowing the identification of such compounds.
    Type: Grant
    Filed: October 23, 2019
    Date of Patent: September 9, 2025
    Assignee: MYELOPRO DIAGNOSTICS AND RESEARCH GmbH
    Inventors: Oleh Zagrijtschuk, Ruochen Jia
  • COMPOUNDS TARGETING MUTANT CALRETICULIN
    Publication number: 20220024944
    Abstract: The present invention relates to compounds binding to calreticulin which selectively inhibit growth of CALR mutant cells and/or exhibit selective cytotoxicity towards CALR mutant cells, to pharmaceutical compositions comprising such compounds as well as to their use in treating diseases or conditions caused by or associated with a mutation of CALR, in particular myeloid malignancies, such as myeloproliferative neoplasms or myelodysplasia syndrome. The present invention also relates to screening assays allowing the identification of such compounds.
    Type: Application
    Filed: October 23, 2019
    Publication date: January 27, 2022
    Inventors: Oleh Zagrijtschuk, Ruochen Jia