Abstract: Provided herein are polypeptides including an amino acid sequence having at least 70% sequence identity with an Isthmin 1 (ISM1) protein or a GRP78-activating fragment thereof, as well as expressible nucleic acids encoding said polypeptides. Uses of such agents, as well as methods for inducing apoptosis in alveolar macrophages and/or for treating, ameliorating, or preventing inflammation or lung disease such as chronic obstructive pulmonary disease (COPD), emphysema, asthma, acute lung injury (ALI), lung fibrosis, and/or acute respiratory distress syndrome.

Abstract: This disclosure provides methods of a method of treating a retinal angiogenic disease in a subject comprising administering an effective amount of an Angio-3 peptide.

Abstract: This disclosure relates to therapeutic agents comprising polypeptides and peptides that include the amino acid sequence motif arginine-lysine-aspartic acid [RKD] and their use in the treatment of conditions associated with abnormal angiogenesis.

Abstract: The present invention provides peptides having potent anti-angiogenic activity and endothelial cell proliferation inhibition activity. The peptides can be administered as pharmaceutical compositions for prevention or treatment of undesired angiogenesis, for instance for prevention of tumor metastasis or inhibition of primary tumor growth.

Abstract: The invention provides a novel surface polypeptide from Aeromonas hydrophila as well as fragments, variants and derivatives of this polypeptide. Also provided are polynucleotides encoding the polypeptide, fragments, variants and derivatives. Compositions containing the polypeptide and polynucleotides of the invention are also disclosed as well as methods useful in the treatment and prevention of bacterial infection in an animal, wherein said infection is caused by bacteria of a genus selected from the group consisting of Aeromonas, Vibrio and Edwardsiella, and in the diagnosis of bacterial infection in an animal, wherein said infection is caused by bacteria of a genus Aeromonas.

Abstract: The present invention provides peptides having potent anti-angiogenic activity and endothelial cell proliferation inhibition activity. The peptides can be administered as pharmaceutical compositions for prevention or treatment of undesired angiogenesis, for instance for prevention of tumor metastasis or inhibition of primary tumor growth.

Abstract: The present invention provides peptides having potent anti-angiogenic activity. The peptides can be administered as pharmaceutical compositions for prevention or treatment of undesired angiogenesis, for instance for prevention of tumor metastasis or inhibition of primary tumor growth.