Patents by Inventor Ruoyao ZHANG

Ruoyao ZHANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aggregation-induced emission luminogens useful for cancer cell discrimination and monitoring
    Patent number: 11965100
    Abstract: Provided herein are aggregation-induced emission luminogens useful for imaging and/or detecting cancer cells and dynamically monitoring the viability of cancer cells and methods of use and preparation thereof.
    Type: Grant
    Filed: April 20, 2021
    Date of Patent: April 23, 2024
    Assignee: The Hong Kong University of Science and Technology
    Inventors: Benzhong Tang, Ruoyao Zhang
  • Single AIEgen for multiple tasks: imaging of dual organelles and evaluation of cell viability
    Patent number: 11754498
    Abstract: A fluorescent probe can include a compound exhibiting aggregation-induced emission (AIE). The probe can be used for selectively staining mitochondria and lipid droplets and detecting esterase activity. The probe includes an acetoxyl group which can be recognized by esterase in an esterase activity assay. As enzyme activity can reflect cell viability, the probe can be useful in cell viability detection. In addition, the probe includes a cationic moiety to target mitochondria and a lipophilic moiety that can target lipid droplets. A calculated log P value of the lipophilic moiety can be larger than 5.
    Type: Grant
    Filed: October 9, 2020
    Date of Patent: September 12, 2023
    Assignee: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Benzhong Tang, Ruoyao Zhang
  • AGGREGATION-INDUCED EMISSION LUMINOGENS USEFUL FOR CANCER CELL DISCRIMINATION AND MONITORING
    Publication number: 20210324199
    Abstract: Provided herein are aggregation-induced emission luminogens useful for imaging and/or detecting cancer cells and dynamically monitoring the viability of cancer cells and methods of use and preparation thereof.
    Type: Application
    Filed: April 20, 2021
    Publication date: October 21, 2021
    Inventors: Benzhong TANG, Ruoyao ZHANG
  • Single AIEgen for Multiple Tasks: Imaging of Dual Organelles and Evaluation of Cell Viability
    Publication number: 20210109024
    Abstract: A fluorescent probe can include a compound exhibiting aggregation-induced emission (AIE). The probe can be used for selectively staining mitochondria and lipid droplets and detecting esterase activity. The probe includes an acetoxyl group which can be recognized by esterase in an esterase activity assay. As enzyme activity can reflect cell viability, the probe can be useful in cell viability detection. In addition, the probe includes a cationic moiety to target mitochondria and a lipophilic moiety that can target lipid droplets. A calculated log P value of the lipophilic moiety can be larger than 5.
    Type: Application
    Filed: October 9, 2020
    Publication date: April 15, 2021
    Inventors: Benzhong TANG, Ruoyao ZHANG