Patents by Inventor Rupert Mutzel

Rupert Mutzel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for obtaining new life forms
    Patent number: 7960103
    Abstract: The present invention relates to a method for generating a novel form of life comprising the steps consisting of: a) irreversible alteration of the genome of a microbial clone; b) cultivation of a vast population of microbial cells originating from the altered clone obtained in step a) during numerous generations under conditions allowing selection for a higher and stable proliferation rate; c) isolation of descendant clones within the cultivated population of step b) still bearing the alteration of step a).
    Type: Grant
    Filed: September 13, 2006
    Date of Patent: June 14, 2011
    Assignees: Institut Pasteur, Evologic SA, Centre National de la Recherche Scientifique
    Inventors: Rupert Mutzel, Philippe Marliere, Didier Mazel
  • Descendants of bacteria devoid of N terminal formylation useful for the production of proteins and peptides
    Patent number: 7399611
    Abstract: Eubacterial cells which produce non-formylated proteins, polypeptides and/or peptides and methods for making such non-formylated products. The eubacterial cells may be produced by inactivating or deleting the def (deformylase) and/or fmt (Met-tRNA transformylase) gene(s) from the def-fmt operon of the corresponding wild-type strain.
    Type: Grant
    Filed: July 8, 2005
    Date of Patent: July 15, 2008
    Assignee: Institut Pasteur
    Inventors: Philippe Marliere, Rupert Mutzel, Didier Mazel
  • Method for obtaining new life forms
    Publication number: 20070212781
    Abstract: The present invention relates to a method for generating a novel form of life comprising the steps consisting of: a) irreversible alteration of the genome of a microbial clone; b) cultivation of a vast population of microbial cells originating from the altered clone obtained in step a) during numerous generations under conditions allowing selection for a higher and stable proliferation rate; c) isolation of descendant clones within the cultivated population of step b) still bearing the alteration of step a).
    Type: Application
    Filed: September 13, 2006
    Publication date: September 13, 2007
    Applicants: INSTITUT PASTEUR, EVOLOGIC SA, Rupert MUTZEL, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Rupert Mutzel, Philippe Marliere, Didier Mazel
  • Descendants of bacteria devoid of N terminal formylation useful for the production of proteins and peptides
    Publication number: 20060014250
    Abstract: Eubacterial cells which produce non-formylated proteins, polypeptides and/or peptides and methods for making such non-formylated products. The eubacterial cells may be produced by inactivating or deleting the def (deformylase) and/or fmt (Met-tRNA transformylase) gene(s) from the def-fmt operon of the corresponding wild-type strain.
    Type: Application
    Filed: July 8, 2005
    Publication date: January 19, 2006
    Applicant: INSTITUT PASTEUR
    Inventors: Philippe Marliere, Rupert Mutzel, Didier Mazel
  • Descendants of bacteria devoid of N terminal formylation useful for the production of proteins and peptides
    Patent number: 6962807
    Abstract: The present invention relates to producing non-formylated proteins and/or peptides in bacterial cells lacking deformylase and/or transformylase.
    Type: Grant
    Filed: July 8, 2002
    Date of Patent: November 8, 2005
    Inventors: Philippe Marliere, Rupert Mutzel, Didier Mazel
  • Method and device for selecting accelerated proliferation of living cells in suspension
    Patent number: 6686194
    Abstract: The present invention relates to a method and a device for selecting accelerated proliferation of living cells in suspension. The culture apparatus (2) of the present invention enables cells to proliferate in suspension over unlimited periods of time. Natural selection results in the accumulation of genetic variants which are increasingly better adapted to the chosen culture conditions. The organisms used can be prokaryotic or eukaryotic. The organisms used can be naturally occurring organisms or genetically modified organisms. The culture apparatus of the present invention is also suitable for using continuous, periodical or conditional culture conditions. The physical and chemical characteristics of the culture media used can be chosen by the user. The requirement that a population of cells proliferates exclusively in suspension in continuous culture conditions is satisfied by the periodical transfer of the organism suspension from a first culture vessel into a second culture vessel.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: February 3, 2004
    Assignees: Institut Pasteur
    Inventors: Rupert Mutzel, Philippe Marliere
  • Descendants of bacteria devoid of N terminal formylation useful for the production of proteins and peptides
    Publication number: 20030143680
    Abstract: The present invention relates to producing non-formylated proteins and/or peptides in bacterial cells lacking deformylase and/or transformylase.
    Type: Application
    Filed: July 8, 2002
    Publication date: July 31, 2003
    Inventors: Philippe Marliere, Rupert Mutzel, Didier Mazel