Publication number: 20250090721
Abstract: Charged citrate-based compositions are provided for use in regenerative applications. The disclosed compositions generally include (i) a citrate component, (ii) a diol, and/or (iii) a charged moiety. The compositions may be used to fabricate scaffolds. The citrate component may take the form of citric acid, citrate, or ester of citric acid, the polyol may take the form of a diol, such as butanediol, hexanediol, octanediol, glycerol or xylitol, and the charged moiety is an anionic or cationic moiety. The anionic moiety may take the form of sulfate, sulfonate, phosphate, phosphonate, sulfamate, or carboxylic acid, and the cationic moiety may take the form of quaternary ammonium, pyridinium, piperidinium, pyrrolidinium, imidazolium, or phosphonium. The anionic or cationic moiety can be presented in the polyol. The composition may include a particulate inorganic material, such as hydroxyapatite, tricalcium phosphate, biphasic calcium phosphate, or bioglass.
Type:
Application
Filed:
September 20, 2024
Publication date:
March 20, 2025
Applicant:
Acuitive Technologies, Inc.
Inventors:
Minh-Tuan Richard Tran, Ruqiang Lu, Angelina Mauriello