Abstract: A plunger assembly of a drug solution dosage device includes a feed screw including a male thread portion and an extending portion, a first plunger including a first female thread portion, a second plunger including a nut accommodating portion, a nut member including a second female thread portion, and a base portion that guides the second plunger. The nut accommodating portion accommodates the nut member so that the nut member is non-rotatable and movable in an axial direction.

Abstract: A drug solution injection device is provided with a barrel, a gasket, and a plunger mechanism. The plunger mechanism is provided with a rotation member, a first moving member, and a second moving member. The plunger mechanism is configured to perform a first extension operation and a second extension operation. In the first extension operation, the first moving member advances to a predetermined position with respect to the rotation member and the second moving member in conjunction with rotation of the rotation member. In the second extension operation, the second moving member advances with respect to the rotation member together with the first moving member after the first extension operation, in conjunction with rotation of the rotation member.

Abstract: To provide a protein preparation which enables reduction of aggregation and a stable long-time preservation, in a protein preparation having a high concentration or a protein preparation susceptible to aggregation. The protein preparation is a gel preparation which is thixotropic and in which an included protein is protected from a physical or chemical stress, is inhibited from aggregation, and thereby stably exists.

Abstract: Provided is a method for producing a protein for medical use/polyamino acid complex, the method being able to more stably improve a formation rate (yield) of the protein for medical use/polyamino acid complex. A method for producing a protein for medical use/polyamino acid complex, the method including forming the complex in a mixed solution obtained by mixing a solution A containing a polyamino acid and at least one of alcohol or a hydrophilic polymer with a solution B containing a protein for medical use.

Abstract: A plunger assembly of a drug solution dosage device includes a feed screw including a male thread portion and an extending portion, a first plunger including a first female thread portion, a second plunger including a nut accommodating portion, a nut member including a second female thread portion, and a base portion that guides the second plunger. A nut accommodating portion accommodates the nut member so that the nut member is non-rotatable and movable in the axial direction.

Abstract: A syringe assembly includes a barrel having a barrel tip portion, a puncture needle projecting from the barrel tip portion, and a cap that is detachably mountable to the barrel so as to seal a distal end of a needle hole. The cap has a receiving hole that receives the puncture needle, a bottom wall portion into which the puncture needle is inserted, and a stopper portion that defines an insertion length of the puncture needle relative to the bottom wall portion. In a state in which the cap is mounted to the barrel, the length from the most proximal position of a contact region between the cap and the puncture needle to the most proximal position of an edge surface is 1 to 3 mm.

Abstract: A puncture assisting device includes a pair of plate-like pinching portions that face each other, and that are attached to each other so as to be openable and closeable; a biasing portion that biases the pair of pinching portions to be in a closed position; a pair of gripping portions configured to operate the pair of pinching portions to be in an open position; and a rod insertion portion that is disposed between the pair of pinching portions, the rod insertion portion being configured such that a rod portion of a syringe is insertable into the rod insertion portion to widen a gap between the pair of pinching portions.

Abstract: A drug solution injection device is provided with a barrel, a gasket, and a plunger mechanism. The plunger mechanism is provided with a rotation member, a first moving member, and a second moving member. The plunger mechanism is configured to perform a first extension operation and a second extension operation. In the first extension operation, the first moving member advances to a predetermined position with respect to the rotation member and the second moving member in conjunction with rotation of the rotation member. In the second extension operation, the second moving member advances with respect to the rotation member together with the first moving member after the first extension operation, in conjunction with rotation of the rotation member.

Abstract: A rubber stopper includes: a main body; and a cylindrical container insertion portion extending downward from a lower surface of the main body and configured to fit into a neck portion of a drug container. The main body includes a peripheral edge portion that is disposed on a radially outer side of the container insertion portion and that is configured to abut on an upper surface of an opening portion of the drug container when attached to the drug container. The container insertion portion includes: an outer surface portion that is configured to annularly contact an inner surface of the neck portion, an upper inner surface portion that forms a columnar gap portion, and at least one inclined surface extending obliquely downward toward the outer surface portion of the container insertion portion.

Abstract: A liquid administration device includes an operation unit; a structure that includes an accommodation body configured to accommodate the liquid therein and a needle tube communicatable with the inside of the accommodation body; a cover member that is movable between a protection position and an exposure position; a biasing member that biases the cover member in a distal direction; an exposure restriction unit configured to restrict movement of the cover member to the exposure position when a movement amount of the cover member with respect to the structure reaches a predetermined exposure restriction operation amount; and a movement amount restriction unit.

Abstract: A liquid administration device includes a structure that includes an accommodation body configured to accommodate liquid therein and a needle configured to communicate with an inside of the accommodation body; an operation unit configured to discharge the liquid inside the accommodation body from the needle by moving toward the structure in a distal direction; a cover member that is movable between a protection position at which the needle is covered and an exposure position at which the needle is exposed; a first biasing member that biases the operation unit toward the structure in the distal direction; and a second biasing member that biases the cover member in the distal direction. The operation unit has a first contact portion and the structure has a second contact portion, the contact portions being configured to come into contact with each other when the operation unit moves toward the structure in the distal direction.

Abstract: A resin hollow needle includes a distal end section including a puncture end portion, a large-diameter section having a diameter greater than that of the distal end section, a tapered section that is located between the large-diameter section and the distal end section, and a hub section. The distal end section includes a hole that is provided on a proximal end side in comparison to a distal end and on a distal end side of the tapered section, and communicates with the inside and the outside of a hollow needle, and a tapered puncture end portion. The distal end section has a total length of 7 to 14 mm and a maximum outer diameter of 1.5 to 3.0 mm. The tapered section has a length of 0.3 to 4.7 mm and a taper angle of 10° to 50°. The large-diameter section has a length of 4 mm or greater, and a distal end outer diameter that is greater than the maximum outer diameter of the distal end section by 0.6 to 3.0 mm.

Abstract: A syringe assembly includes a barrel having a barrel tip portion, a puncture needle projecting from the barrel tip portion, and a cap that is detachably mountable to the barrel so as to seal a distal end of a needle hole. The cap has a receiving hole that receives the puncture needle, a bottom wall portion into which the puncture needle is inserted, and a stopper portion that defines an insertion length of the puncture needle relative to the bottom wall portion. In a state in which the cap is mounted to the barrel, the length from the most proximal position of a contact region between the cap and the puncture needle to the most proximal position of an edge surface is 1 to 3 mm.

Abstract: A puncture assisting device includes a pair of plate-like pinching portions that face each other, and that are attached to each other so as to be openable and closeable; a biasing portion that biases the pair of pinching portions to be in a closed position; a pair of gripping portions configured to operate the pair of pinching portions to be in an open position; and a rod insertion portion that is disposed between the pair of pinching portions, the rod insertion portion being configured such that a rod portion of a syringe is insertable into the rod insertion portion to widen a gap between the pair of pinching portions.

Abstract: To provide a protein preparation which enables reduction of aggregation and a stable long-time preservation, in a protein preparation having a high concentration or a protein preparation susceptible to aggregation. The protein preparation is a gel preparation which is thixotropic and in which an included protein is protected from a physical or chemical stress, is inhibited from aggregation, and thereby stably exists.

Abstract: A liquid administration device includes an operation unit; a structure that includes an accommodation body configured to accommodate the liquid therein and a needle tube communicatable with the inside of the accommodation body; a cover member that is movable between a protection position and an exposure position; a biasing member that biases the cover member in a distal direction; an exposure restriction unit configured to restrict movement of the cover member to the exposure position when a movement amount of the cover member with respect to the structure reaches a predetermined exposure restriction operation amount; and a movement amount restriction unit.

Abstract: A liquid administration device includes a structure that includes an accommodation body configured to accommodate liquid therein and a needle configured to communicate with an inside of the accommodation body; an operation unit configured to discharge the liquid inside the accommodation body from the needle by moving toward the structure in a distal direction; a cover member that is movable between a protection position at which the needle is covered and an exposure position at which the needle is exposed; a first biasing member that biases the operation unit toward the structure in the distal direction; and a second biasing member that biases the cover member in the distal direction. The operation unit has a first contact portion and the structure has a second contact portion, the contact portions being configured to come into contact with each other when the operation unit moves toward the structure in the distal direction.