Abstract: Embodiments of negative pressure wound therapy systems, apparatuses, and methods for operating the systems and apparatuses are disclosed. In some embodiments, the apparatus includes a negative pressure source, a connector port, at least one switch, and a controller. The negative pressure source is connected through the connector port to either (i) a wound dressing having a canister configured to store fluid aspirated from the wound or (ii) a wound dressing without a canister between the connector port and the wound dressing. The controller determines, based on a signal received from the at least one switch, whether the canister is positioned in the fluid flow path and adjusts one or more operational parameters of negative pressure wound therapy based on the determination. The switch is activated by the connection of either the canister or canisterless wound dressing to the apparatus.

Abstract: Provided herein are compositions and methods of making high density nucleic acid polymers.

Abstract: In some examples, a first computing device of a plurality of computing devices may be a member of a first partition group. For example, the first partition group may correspond to a first partition of multiple partitions of a metadata database. The first partition group may include at least one other computing device. Furthermore, each of the plurality of computing devices may maintain at least one partition of the metadata database so that the metadata database is partitioned into multiple partitions distributed across the computing devices. The first computing device may determine a first time threshold for a heartbeat communication to be sent to the other computing device(s) in the first partition group, and may select a random time before the first time threshold. The first computing device may send, based on the selected random time, the heartbeat communication to the other computing device(s) in the first partition group.

Abstract: According to one embodiment, a thermal management system for electronic devices, including a heat frame, a conformal slot portion, chassis frame, and heat fins wherein the heat frame, conformal slot, chassis frame, and heat fins are integrally formed as a unitary structure by additive manufacturing. In another example, there is a modular vapor assembly for electronic components having a vapor chamber comprising a component surface and a top surface with a vapor channel formed therebetween with at least one liquid receptacle and having a wick structure on at least some of an interior of the component surface. In operation, there is a circuit card with at least some of the electronic components coupled to the vapor chamber component surface and the wick structures transfer at least some of the liquid from the receptacle towards the electronic components, wherein the liquid turns to a vapor that moves towards the receptacle.

Abstract: Provided herein are engineered hMPV F proteins. In some aspects, the engineered F proteins exhibit enhanced conformational stability and/or antigenicity. Methods are also provided for use of the engineered F proteins as diagnostics, in screening platforms, and/or in vaccine compositions.

Abstract: Systems and methods which allow for the integration of occupancy detection with traditional leak detection systems to further enhance the detection of dangerous leaks and allow them to be responded to in a more effective manner. The occupancy system will typically be integrated with flow detection systems, however, water presence detectors can also be integrated in another embodiment.

Abstract: The present invention provides compounds of the formula: wherein A, Z, G, R1, R2, and R4 are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and pharmaceutically acceptable salts thereof for treating patients for cancer.

Abstract: An application for providing a flight planning tool is disclosed. The application may be configured to execute on a client device to: establish, using at least one Application Program Interface (API), communication between the client device and a system; receive a request based on a user input indicative of first information related to a flight; request, from the system, flight plan information based on the first information and second information from a third-party device; receive the flight plan information; and provide one or more user interfaces for displaying the flight plan information at the client device.

Abstract: Immersive systems and methods are provided for aggregation and organization of image, video and digital rights data. In exemplary embodiments, a system and method for aggregation and organization of media data acquired from a plurality of sources is provided. The system and method include a data collection element, a brand commercial (POPmercial) placement for sponsorship element, a stake and mining rewards (Futures In Popular) against placed media element and a user interface that allows publishing of a unique curated media stream as a first-time-ever NFT BROADCAST, (POPcast). Automated fair use, media literacy precepts, digital rights management, data harvesting, personalized content curation including story arc curation, emotion and bias identification and multiple metaverses and virtual worlds including e-commerce worlds may all be provided in within a gamified internet network.

Abstract: A processing device including a plurality of clusters of processor cores and a method for use in the processing device is disclosed. Each processor core in a cluster of processor cores is in communication with the other processor cores in the cluster and at least one processor core of each cluster is in communication with at least a processor core of a different cluster of processor cores. Each processor core is configured to store a product of a portion of a first matrix and a first portion of a second matrix in the memory, and store a product of the portion of the first matrix and a second portion of the second matrix in the memory, where the second portion of the second matrix is received from a processor core in the cluster of processor cores.

Abstract: Methods of screening types and amounts of antioxidants, determining effectiveness of the antioxidants, preparing compositions including effective amounts of the antioxidants (and uses thereof), and reducing the formation of clogged pores and acne are provided. Methods include the formation of test samples in a solvent system (optionally with one or more bacterial metabolites) including one or more antioxidants in amounts to be evaluated for effectiveness against control samples without antioxidants. The samples are exposed to an oxidation-inducing element (such as UVA rays) and the amount of oxidation byproduct is evaluated. Based on the effectiveness of the antioxidant(s) in the amount(s) tested, formulations can be prepared to include the one or more antioxidants in the amount(s) effective to reduce oxidation of the oxidizable component, preventing and reducing the formation of the oxidation byproduct. The formulations can be used, for example, to reduce the formation of clogged pores and acne.

Abstract: An all-in-one osteotomy fixation device, along with various related components, systems, and methods. The various embodiments include a device body, a bone attachment structure, a removable slot body, and a movable cutting guide moveably attached to the body via a guide coupling structure. The various methods include using any single device embodiment herein to perform all of the steps of the osteotomy procedure.

Abstract: Certain aspects of the present disclosure provide a monitoring system comprising a continuous analyte sensor configured to generate a first set of analyte measurements associated with analyte levels of a host, and a sensor electronics module coupled to the continuous analyte sensor and configured to receive and process the first set of analyte measurements.

Abstract: Certain aspects of the present disclosure provide a monitoring system comprising a continuous analyte sensor configured to generate a first set of analyte measurements associated with analyte levels of a patient, and a sensor electronics module coupled to the continuous analyte sensor and configured to receive and process the first set of analyte measurements.

Abstract: An electric motor may include a stator assembly comprising a stator housing, and one or more rotors coupled to the stator by a rotor shaft assembly. The stator housing may include a cooling structure that has a plurality of cooling body portions and a plurality of cooling conduits defined by the plurality of cooling body portions. A method of forming a stator housing for an electric machine may include additively manufacturing a stator housing that includes a cooling structure defining a fluid domain, coupling a working fluid source to the stator housing and introducing a working fluid into the fluid domain defined by the cooling structure, and sealing the cooling structure with the working fluid contained within the fluid domain of the cooling structure.

Abstract: A prosthetic device includes a polymer lattice structure. The lattice structure includes a first surface arranged to face toward a residual limb, a second surface arranged to face away from the residual limb, a thickness between the first and second surfaces, and a variable lattice density across the thickness.

Abstract: The invention is directed to an engineered yeast including an exogenous nucleic acid encoding a glucoamylase comprising SEQ ID NO:1 and SEQ ID NO:4, or a variant thereof. The engineered yeast are able to provide glucoamylase into a fermentation media and cause degradation of starch material generating glucose for fermentation to a desired bioproduct, such as ethanol. High titers of bioproduct (e.g., 70 g/kg of ethanol) can be achieved, along with low residual glucose levels. Further the yeast exhibit good growth and bioproduct product at temperatures of 32° C. or greater.

Abstract: A universal filtering mouthpiece for smoking devices comprising a flexible and substantially conical shaped body having a small diameter end and a large diameter end; a hollow smoke passage which runs axially through the conical shaped body from the small diameter end to the large diameter end; a filter cartridge housing centered axially at the mouthpiece end of the said flexible and substantially conical shaped body which communicates with the hollow smoke passage and capable of housing a removable filter; and a disposable, high-airflow filter cartridge consisting of a rigid cylindrical frame having rounded edges, the rigid cylindrical frame housing a smoke filter inside the inner diameter of said rigid cylindrical frame. The universal filtering mouthpiece for smoking devices is readily implementable across a wide variety of smoking devices such as, but not limited to, pipes, bongs, hookahs, water pipes, electronic cigarettes, cigarettes, and pre-roll cigarettes.