Patents by Inventor Ruslan M. Medzhitov

Ruslan M. Medzhitov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions of pamps and Listeria monocytogenes and methods of use
    Publication number: 20090081725
    Abstract: A composition comprising a pathogen associated molecular pattern (PAMP) protein that activates toll-like receptor 2 (TLR2) or toll-like receptor 5 (TLR5) signaling and at least two distinct antigens of Listeria monocytogenes. Amino acids, nucleotides, vectors, cell lines, and the methods for production and use of the compositions are provided.
    Type: Application
    Filed: August 3, 2006
    Publication date: March 26, 2009
    Inventors: Thomas J. Powell, Ruslan M. Medzhitov
  • RIP2: a mediator of signaling in the innate and adaptive immune systems
    Publication number: 20030224388
    Abstract: This invention provides a method of identifying a compound that modulates an innate immune response and an adaptive immune response comprising contacting cells expressing RIP2 with a candidate compound, and determining whether the candidate compound modulates RIP2 activity in the cells, wherein modulation of RIP2 activity in the cells by the candidate compound indicates that the candidate compound modulates the innate immune response and adaptive immune response.
    Type: Application
    Filed: January 9, 2003
    Publication date: December 4, 2003
    Inventors: Richard A. Flavell, Ruslan M. Medzhitov, Koichi Kobayashi
  • Innate immune system-directed vaccines
    Publication number: 20030175287
    Abstract: The present invention provides novel vaccines, methods for the production of such vaccines and methods of using such vaccines. The novel vaccines of the present invention combine both of the signals necessary to activate native T-cells—a specific antigen and the co-stimulatory signal—leading to a robust and specific T-cell immune response.
    Type: Application
    Filed: December 13, 2002
    Publication date: September 18, 2003
    Applicant: Yale University
    Inventors: Ruslan M. Medzhitov, Elizabeth Kopp
  • IRAK-M is a negative regulator of toll-like receptor signaling
    Publication number: 20030157539
    Abstract: Isolated nucleic acid encoding the amino acid sequence of murine IRAK-M; expression vectors comprising nucleic acid encoding IRAK-M and host cells comprising them are disclosed. IRAK-M is induced upon toll-like receptor (TLR) stimulation and negatively regulates TLR signaling. Methods for identifying antagonists and agonists of IRAK-M are described.
    Type: Application
    Filed: January 9, 2003
    Publication date: August 21, 2003
    Applicant: Yale University
    Inventors: Richard A. Flavell, Koichi Kobayashi, Ruslan M. Medzhitov