Patents by Inventor Russel C. Sequeira

Russel C. Sequeira has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OVARIAN FOLLICLE CELLS AND CONSTRUCTS FOR FERTILITY TREATMENT AND HORMONE REPLACEMENT THERAPY
    Publication number: 20260185044
    Abstract: A method of providing a culture of oogonia stem cells comprising oogonia stem cells is provided. The method may further include culturing the oogonia stem cells with granulosa and theca cells to differentiate the oogonia stem cells into oocytes. In some embodiments, the culturing comprises including the oogonia stem cells in an in vitro follicle construct or a microcapsule comprising said granulosa and theca cells. Further described herein is a method of forming a bioengineered follicle construct capable of releasing a mature oocyte. An in vitro fertilization method using the mature oocyte is also provided.
    Type: Application
    Filed: February 25, 2026
    Publication date: July 2, 2026
    Inventors: Sittadjody Sivanandane, Russel C. Sequeira, John D. Jackson, Anthony Atala, James J. Yoo
  • Ovarian follicle cells and constructs for fertility treatment and hormone replacement therapy
    Patent number: 12584104
    Abstract: A method of providing a culture of oogonia stem cells comprising oogonia stem cells is provided. The method may further include culturing the oogonia stem cells with granulosa and theca cells to differentiate the oogonia stem cells into oocytes. In some embodiments, the culturing comprises including the oogonia stem cells in an in vitro follicle construct or a microcapsule comprising said granulosa and theca cells. Further described herein is a method of forming a bioengineered follicle construct capable of releasing a mature oocyte. An in vitro fertilization method using the mature oocyte is also provided.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: March 24, 2026
    Assignee: Wake Forest University Health Sciences
    Inventors: Sittadjody Sivanandane, Russel C. Sequeira, John D. Jackson, Anthony Atala, James J. Yoo
  • OVARIAN FOLLICLE CELLS AND CONSTRUCTS FOR FERTILITY TREATMENT AND HORMONE REPLACEMENT THERAPY
    Publication number: 20220010270
    Abstract: A method of providing a culture of oogonia stem cells comprising oogonia stem cells is provided. The method may further include culturing the oogonia stem cells with granulosa and theca cells to differentiate the oogonia stem cells into oocytes. In some embodiments, the culturing comprises including the oogonia stem cells in an in vitro follicle construct or a microcapsule comprising said granulosa and theca cells. Further described herein is a method of forming a bioengineered follicle construct capable of releasing a mature oocyte. An in vitro fertilization method using the mature oocyte is also provided.
    Type: Application
    Filed: September 27, 2021
    Publication date: January 13, 2022
    Inventors: Sittadjody Sivanandane, Russel C. Sequeira, John D. Jackson, Anthony Atala, James J. Yoo