Patents by Inventor Russel E. Kaufman

Russel E. Kaufman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and Compositions for Treating or Diagnosing Melanoma
    Publication number: 20150166646
    Abstract: Methods and compositions are provided for treating melanoma in a mammalian subject by reducing, inhibiting or down-regulating tumor-associated macrophage (TAM) production or activity in the subject. The methods can involve a combination of reducing macrophage production and number while administering an anti-cancer therapy. The treatment can involve the combined blocking or down-regulating of the nucleic acid or protein expression or activity, or the downstream pathway of CCL-2; with the blocking or down-regulating of the nucleic acid or protein expression or activity, or the downstream pathway of a matrix metalloprotease (e.g., MMP9). Another aspect involves blocking the expression or activity of VEGF. Another aspect involves blocking or down-regulating the expression, activity or signaling of the MAPK pathway or the PI3K-AKT-mTOR pathway.
    Type: Application
    Filed: March 15, 2013
    Publication date: June 18, 2015
    Inventors: Tao Wang, Meenhard Herlyn, Russel E. Kaufman
  • Antibodies to the K12 protein
    Patent number: 7022820
    Abstract: The present invention relates, in general, to a cancer-related protein and to a nucleic acid sequence encoding same. In particular, the invention relates to a protein over expressed in certain neoplastic cells, including breast and ovarian cancer cells, to its encoding sequence, and to diagnostic and treatment methodologies based on same.
    Type: Grant
    Filed: February 25, 2002
    Date of Patent: April 4, 2006
    Assignee: Duke University
    Inventors: Russel E. Kaufman, Kimberly Slentz-Kesler
  • Gene product over expressed in cancer cells
    Publication number: 20030096326
    Abstract: The present invention relates, in general, to a cancer-related protein and to a nucleic acid sequence encoding same. In particular, the invention relates to a protein over expressed in certain neoplastic cells, including breast and ovarian cancer cells, to its encoding sequence, and to diagnostic and treatment methodologies based on same.
    Type: Application
    Filed: February 25, 2002
    Publication date: May 22, 2003
    Applicant: DUKE UNIVERSITY
    Inventors: Russel E. Kaufman, Kimberly Slentz-Kesler
  • Gene product over expressed in cancer cells
    Patent number: 6350615
    Abstract: The present invention relates, in general, to a cancer-related protein and to a nucleic acid sequence encoding same. In particular, the invention relates to a protein over expressed in certain neoplastic cells, including breast and ovarian cancer cells, to its encoding sequence, and to diagnostic and treatment methodologies based on same.
    Type: Grant
    Filed: March 31, 2000
    Date of Patent: February 26, 2002
    Assignee: Duke University
    Inventors: Russel E. Kaufman, Kimberly Slentz-Kesler
  • Gene product over expressed in cancer cells
    Patent number: 6072034
    Abstract: The present invention relates, in general, to a cancer-related protein and to a nucleic acid sequence encoding same. In particular, the invention relates to a protein over expressed in certain neoplastic cells, including breast and ovarian cancer cells, to its encoding sequence, and to diagnostic and treatment methodologies based on same.
    Type: Grant
    Filed: December 14, 1998
    Date of Patent: June 6, 2000
    Assignee: Duke University
    Inventors: Russel E. Kaufman, Kimberly Slentz-Kesler
  • Gene product over expressed in cancer cells
    Patent number: 5912142
    Abstract: The present invention relates, in general, to a cancer-related protein and to a nucleic acid sequence encoding same. In particular, the invention relates to a protein over expressed in certain neoplastic cells, including breast and ovarian cancer cells, to its encoding sequence, and to diagnostic and treatment methodologies based on same.
    Type: Grant
    Filed: November 22, 1996
    Date of Patent: June 15, 1999
    Assignee: Duke University
    Inventors: Russel E. Kaufman, Kimberly Slentz-Kesler