Patents by Inventor Russel Jackson Lander

Russel Jackson Lander has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purification process for plasmid DNA
    Patent number: 7767399
    Abstract: Methods of isolating clinical-grade plasmid DNA from manufacturing processes, including large-scale fermentation regimes, are disclosed which encompass alternatives to two core unit operations common to plasmid DNA purification processes. The novel upstream and downstream purification processes disclosed herein provide for reduced production costs and increase process robustness. Either or both of the purification processes disclosed herein may be used in combination with additional purification steps known in the art that are associated with DNA plasmid purification technology.
    Type: Grant
    Filed: January 27, 2006
    Date of Patent: August 3, 2010
    Assignee: Merck & Co., Inc.
    Inventors: Jason C. Murphy, David B. Boyd, Adam Joel Kristopeit, Russel Jackson Lander, Michael Albert Winters
  • Upstream and a Downstream Purification Process for Large Scale Production of Plasmid Dna
    Publication number: 20080138886
    Abstract: Methods of isolating clinical-grade plasmid DNA from manufacturing processes, including large-scale fermentation regimes, are disclosed which encompass alternatives to two core unit operations common to plasmid DNA purification processes. The novel upstream and downstream purification processes disclosed herein provide for reduced production costs and increase process robustness. Either or both of the purification processes disclosed herein may be used in combination with additional purification steps known in the art that are associated with DNA plasmid purification technology.
    Type: Application
    Filed: January 27, 2006
    Publication date: June 12, 2008
    Inventors: Jason C. Murphy, David B. Boyd, Adam Joel Kristopeit, Russel Jackson Lander, Michael Albert Winters
  • Process for the scaleable purification of plasmid DNA
    Patent number: 7285651
    Abstract: The present invention relates to a nonchromatographic-based process for the isolation of clinical grade plasmid DNA from bacterial cells. The exemplified methods described herein outline a scaleable, economically favorable protocol for the purification of clinical grade plasmid DNA from E. coli which includes CTAB-based precipitation of DNA in combination with adsorption of impurities to calcium silicate.
    Type: Grant
    Filed: August 19, 2004
    Date of Patent: October 23, 2007
    Assignee: Merck & Co., Inc.
    Inventors: Russel Jackson Lander, Michael Albert Winters, Francis Jeremiah Meacle
  • Process for the scaleable purification of plasmid DNA
    Patent number: 6797476
    Abstract: The present invention relates to a nonchromatographic-based process for the isolation of clinical grade plasmid DNA from bacterial cells. The exemplified methods described herein outline a scaleable, economically favorable protocol for the purification of clinical grade plasmid DNA from E. coli which includes CTAB-based precipitation of DNA in combination with adsorption of impurities to calcium silicate.
    Type: Grant
    Filed: April 1, 2002
    Date of Patent: September 28, 2004
    Assignee: Merck & Co., Inc.
    Inventors: Russel Jackson Lander, Michael Albert Winters, Francis Jeremiah Meacle
  • Process for the scaleable purification of plasmid DNA
    Publication number: 20020151048
    Abstract: The present invention relates to a nonchromatographic-based process for the isolation of clinical grade plasmid DNA from bacterial cells. The exemplified methods described herein outline a scaleable, economically favorable protocol for the purification of clinical grade plasmid DNA from E. coli which includes CTAB-based precipitation of DNA in combination with adsorption of impurities to calcium silicate.
    Type: Application
    Filed: April 1, 2002
    Publication date: October 17, 2002
    Applicant: Merck & Co., Inc.
    Inventors: Russel Jackson Lander, Michael Albert Winters, Francis Jeremiah Meacle
  • Process for the scaleable purification of plasmid DNA
    Publication number: 20020012990
    Abstract: The present invention relates to a nonchromatographic-based process for the isolation of clinical grade plasmid DNA from bacterial cells. The exemplified methods described herein outline a scaleable, economically favorable protocol for the purification of clinical grade plasmid DNA from E. coli which includes CTAB-based precipitation of DNA in combination with adsorption of impurities to calcium silicate.
    Type: Application
    Filed: June 6, 2001
    Publication date: January 31, 2002
    Inventors: Russel Jackson Lander, Michael Albert Winters, Francis Jeremiah Meacle
  • Process for the scaleable purification of plasmid DNA
    Publication number: 20010044136
    Abstract: The present invention relates to a nonchromatographic-based process for the isolation of clinical grade plasmid DNA from bacterial cells. The exemplified methods described herein outline a scaleable, economically favorable protocol for the purification of clinical grade plasmid DNA from E. coli which includes CTAB-based precipitation of DNA in combination with adsorption of impurities to calcium silicate.
    Type: Application
    Filed: December 21, 2000
    Publication date: November 22, 2001
    Inventors: Russel Jackson Lander, Michael Albert Winters, Francis Jeremiah Meacle