Patents by Inventor Russel Thomas

Russel Thomas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Azole methylidene cyanide derivatives and their use as protein kinase modulators
    Publication number: 20070123530
    Abstract: An azole derivative of formula (I) a medicament that contains the azole derivative of formula (I), a method of treating a disease with the azole derivative of formula (I), and a method of preparing the azole derivative of formula (I).
    Type: Application
    Filed: June 13, 2003
    Publication date: May 31, 2007
    Inventors: Pascale Gaillard, Jean-Pierre Gottenland, Isabelle Jeanclaude-Etter, Matthias Schwarz, Russel Thomas
  • Aryl dicarboxamides
    Publication number: 20060189583
    Abstract: The present invention is related to aryl dicarboxamides of formula (I) and use thereof for the treatment and/or prevention of obesity and/or metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type I and/or II, inadequate glucose tolerance, insulin resistance, hyperlipidemia, hypertriglyceridemia, hypercholes-terolemia, polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of aryl dicarboxamides of formula (I) to modulate, notably to inhibit the activity of PTPs.
    Type: Application
    Filed: July 20, 2004
    Publication date: August 24, 2006
    Inventors: Russel Thomas, Dominique Swinnen, Jean-Francois Pons, Agnes Bombrun
  • Pharmaceutically active pyrrolidine derivatives as Bax inhibitors
    Patent number: 7018988
    Abstract: The present invention is related to new substituted pyrrolidine derivatives of formula (I). Said compounds are preferably for use as pharmaceutically active compounds. Specifically, pyrrolidine derivatives of formula (I) are useful in the treatment and/or prevention of neurodegenerative disorders, diseases associated with polygultamine tracts, epilepsy, ischemia, infertility, cardiovascular disorders renal hypoxia, hepatitis and AIDS. Said pyrrolidine derivatives display a modulatory and most notably a down-regulating-up to an inhibitory-activity with respect to the cellular death agonist Bax and/or the activation pathways leading to Bax and allows therefore to block the release of cytochrome (c).
    Type: Grant
    Filed: March 20, 2001
    Date of Patent: March 28, 2006
    Assignee: Applied Research Systems ARS Holding N.V.
    Inventors: Serge Halazy, Anna Quattropani, Agnes Bombrun, Mattias Schwarz, Russel Thomas, Anthony Baxter
  • Pharmaceutically active pyrrolidine derivatives as bax inhibitors
    Publication number: 20030171309
    Abstract: The present invention is related to new substituted pyrrolidine derivatives of formula (I). Said compounds are preferably for use as pharmaceutically active compounds. Specifically, pyrrolidine derivatives of formula (I) are useful in the treatment and/or prevention of neurodegenerative disorders, diseases associated with polygultamine tracts, epilepsy, ischemia, infertility, cardiovascular disorders renal hypoxia, hepatitis and AIDS. Said pyrrolidine derivatives display a modulatory and most notably a down-regulating-up to an inhibitory-activity with respect to the cellular death agonist Bax and/or the activation pathways leading to Bax and allows therefore to block the release of cytochrome (c).
    Type: Application
    Filed: April 28, 2003
    Publication date: September 11, 2003
    Inventors: Serge Halazy, Anna Quattropani, Agnes Bombrun, Mattias Schwarz, Russel Thomas, Anthony Baxter
  • Process for the preparation of cyclohexyl-azetidinones
    Patent number: 5817806
    Abstract: 1. A process for the preparation of compounds of formula (I) wherein R.sub.1 is a hydroxyl protecting group ##STR1## which comprises reacting the azetidinone (II) with the homochiral (2S)-2- methoxycyclohexane (III) or the complex thereof formed with one molecule of stannic chloide.
    Type: Grant
    Filed: January 3, 1997
    Date of Patent: October 6, 1998
    Assignee: Glaxo Wellcome SpA
    Inventors: Tino Rossi, Paola Zarantonello, John Russel Thomas