Patents by Inventor Russell A. Kern

Russell A. Kern has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of neural cells derived from human pluripotent stem cells for the treatment of neurodegenerative diseases
    Patent number: 11007232
    Abstract: The present invention is based in part methods for treating neurodegenerative diseases and disorders. Specifically, the present invention disclose methods for treating neurodegenerative disorders suing neural stem cells (NSCs) and/or pluripotent stem cell (PSC) derived neurons or neuron precursor cells. The present invention also discloses methods to induce endogenous dopaminergic neurons to release dopamine and increase the levels of dopamine in a subject.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: May 18, 2021
    Assignee: International Stem Cell Corporation
    Inventors: Russell A. Kern, Rodolfo Gonzalez, Ibon Garitaonandia
  • CHEMICAL DIFFERENTIATION OF PLURIPOTENT STEM CELLS INTO RETINAL EPITHELIAL CELLS
    Publication number: 20200024573
    Abstract: The present invention is based in part on a chemically defined method of generating retinal epithelial cells and retinal pigmented epithelial cells from human pluripotent stem cells (hpSCs). The present invention also provides methods and kits for treating degenerative eye disorders.
    Type: Application
    Filed: September 16, 2019
    Publication date: January 23, 2020
    Inventors: Russell A. Kern, Rodolfo Gonzalez
  • Chemical differentiation of pluripotentstem cells into retinal epithelial cells
    Patent number: 10457915
    Abstract: The present invention is based in part on a chemically defined method of generating retinal epithelial cells and retinal pigmented epithelial cells from human pluripotent stem cells (hpSCs). The present invention also provides methods and kits for treating degenerative eye disorders.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: October 29, 2019
    Assignee: International Stem Cell Corporation
    Inventors: Russell A. Kern, Rodolfo Gonzalez
  • Small molecules that promote skin regeneration
    Patent number: 10335422
    Abstract: Provided herein are small molecules for the induction of fibroblast proliferation and increased secretion or production of proteins. The small molecules described herein can be used for the promotion of skin regeneration. Also provided herein are methods for promoting skin regeneration and wound healing.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: July 2, 2019
    Assignee: International Stem Cell Corporation
    Inventors: Rodolfo Gonzalez, Maxim Poustovoitov, Russell A. Kern
  • Method of prevention of neurological diseases
    Patent number: 10258632
    Abstract: Provided herein are small molecules that have a neuroprotective or modulatory effect in the nervous system. The small molecules provided herein modulate dopaminergic neuronal activity. Also provided herein are methods of for the prophylaxis of or preventing the progression of Parkinson's Disease (PD).
    Type: Grant
    Filed: June 3, 2013
    Date of Patent: April 16, 2019
    Assignee: International Stem Cell Corporation
    Inventors: Rodolfo Gonzalez, Ibon Garitaonandia, Russell A. Kern
  • Topical Skin Care Compositions and Methods
    Publication number: 20190105354
    Abstract: Topical compositions containing lysate of human parthenogenetic stem cells (hpSCs), preferably within a liposomal dispersion, that reduce the visible signs of skin aging and/or cellulite.
    Type: Application
    Filed: December 4, 2018
    Publication date: April 11, 2019
    Inventors: Andrey Semechkin, Nikolay A. Turovets, Larissa S. Agapova, Russell A. Kern, Jeffrey D. Janus
  • Topical skin care compositions and methods
    Patent number: 10172890
    Abstract: Topical compositions containing lysate of human parthenogenetic stem cells (hpSCs), preferably within a liposomal dispersion, that reduce the visible signs of skin aging and/or cellulite.
    Type: Grant
    Filed: August 2, 2011
    Date of Patent: January 8, 2019
    Inventors: Andrey Semechkin, Nikolay A. Turovets, Larisa S. Agapova, Russell A. Kern, Jeffrey D. Janus
  • USE OF NEURAL CELLS DERIVED FROM HUMAN PLURIPOTENT STEM CELLS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
    Publication number: 20180339000
    Abstract: The present invention is based in part methods for treating neurodegenerative diseases and disorders. Specifically, the present invention disclose methods for treating neurodegenerative disorders suing neural stem cells (NSCs) and/or pluripotent stem cell (PSC) derived neurons or neuron precursor cells. The present invention also discloses methods to induce endogenous dopaminergic neurons to release dopamine and increase the levels of dopamine in a subject.
    Type: Application
    Filed: August 6, 2018
    Publication date: November 29, 2018
    Inventors: Russell A. Kern, Rodolfo Gonzalez, Ibon Garitaonandia
  • USE OF NEURAL CELLS DERIVED FROM HUMAN PLURIPOTENT STEM CELLS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
    Publication number: 20180339001
    Abstract: The present invention is based in part methods for treating neurodegenerative diseases and disorders. Specifically, the present invention disclose methods for treating neurodegenerative disorders suing neural stem cells (NSCs) and/or pluripotent stem cell (PSC) derived neurons or neuron precursor cells. The present invention also discloses methods to induce endogenous dopaminergic neurons to release dopamine and increase the levels of dopamine in a subject.
    Type: Application
    Filed: August 6, 2018
    Publication date: November 29, 2018
    Inventors: Russell A. Kern, Rodolfo Gonzalez, Ibon Garitaonandia
  • Use of neural cells derived from human pluripotent stem cells for the treatment of neurodegenerative diseases
    Patent number: 10039794
    Abstract: The present invention is based in part methods for treating neurodegenerative diseases and disorders. Specifically, the present invention disclose methods for treating neurodegenerative disorders suing neural stem cells (NSCs) and/or pluripotent stem cell (PSC) derived neurons or neuron precursor cells. The present invention also discloses methods to induce endogenous dopaminergic neurons to release dopamine and increase the levels of dopamine in a subject.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: August 7, 2018
    Assignee: International Stem Cell Corporation
    Inventors: Russell A. Kern, Rodolfo Gonzalez, Ibon Garitaonandia