Abstract: The present invention provides methods for treating cancers having a mutation in one or more tumor suppressor genes, comprising providing to a subject in need thereof an inhibitor of a kinase, as well as related methods and compositions.

Abstract: A tire includes a body ply sheet having a rubber core defined by a top surface having a length and a width, a bottom surface having substantially the same length and width, and side surfaces having a common height. The body ply sheet includes reinforcement cords spaced 0.1-4.0 mm apart from each other and spanning the width of the body ply sheet. Bleeder cords are disposed on the body ply sheet and spaced are 8-12 cm apart from each other. Conductive cords are also disposed on the body ply and are spaced 20-80 cm apart from each other. At least one of the conductive cords has a first end and a second end, the first end being located in a region within a middle 80% of a width of the circumferential tread.

Abstract: A tire includes a body ply sheet having a rubber core defined by a top surface having a length and a width, a bottom surface having substantially the same length and width, and side surfaces having a common height. The rubber core is further defined by a top rubber layer and a bottom rubber layer. The body ply sheet includes reinforcement cords disposed between the top rubber layer and the bottom rubber layer. The reinforcement cords are spaced 0.1-4.0 mm apart from each other and span the width of the body ply sheet. Bleeder cords are disposed on the body ply sheet and spaced 8-12 cm apart from each other. Conductive cords are also disposed on the body ply and spaced 20-80 cm apart from each other.

Abstract: The present invention provides methods for treating cancers having a mutation in one or more tumor suppressor genes, comprising providing to a subject in need thereof an inhibitor of a kinase, as well as related methods and compositions.

Abstract: An apparatus and method are disclosed for modeling at least a portion of a rolling tire (200). A finite element model of at least a portion of a tire (200) rolling against a tire contacting surface (202, 506, 602) is input into a finite element analysis system (100). The system executed instructions that result in the application of a constant force to the model tire (200) or portion thereof by the tire contacting surface (202, 506, 602). The application of force control boundary conditions, as opposed to displacement control, provides significant benefit in terms of computational time of the finite element analysis solution. A finite element analysis simulation of the model against the tire contacting surface (202, 506, 602) is performed while maintaining the force on the model tire (200). Alternatively, a camber (?) is also applied to the tire and maintained throughout the simulation.

Abstract: A tire includes annular beads, a body ply extending between the annular beads, and a circumferential belt disposed radially outward of the body ply. The tire further includes a circumferential tread disposed radially outward of the circumferential belt. At least three circumferential grooves divide the tread into two outer circumferential ribs and two inner circumferential ribs. A plurality of rib sipes are disposed on at least one circumferential rib. The tire includes a plurality of curvilinear spline sipes, wherein each curvilinear spline sipe has multiple inflection points. At least one curvilinear spline sipe is disposed on an outer circumferential rib and at least one curvilinear spline sipe is disposed on a different circumferential rib. A localized depth of the at least one curvilinear spline sipe disposed on the outer circumferential rib varies in proportion to the distance from the rib sipes that intersect the at least one curvilinear spline sipe.

Abstract: A tire includes a body ply sheet having a rubber core defined by a top surface having a length and a width, a bottom surface having substantially the same length and width, and side surfaces having a common height. The rubber core is further defined by a top rubber layer and a bottom rubber layer. The body ply sheet includes reinforcement cords disposed between the top rubber layer and the bottom rubber layer. The reinforcement cords are spaced 0.1-4.0 mm apart from each other and span the width of the body ply sheet. Bleeder cords are disposed on the body ply sheet and spaced 8-12 cm apart from each other. Conductive cords are also disposed on the body ply and spaced 20-80 cm apart from each other.

Abstract: A tire includes annular beads, a body ply extending between the annular beads, and a circumferential belt disposed radially outward of the body ply. The tire further includes a circumferential tread disposed radially outward of the circumferential belt. At least three circumferential grooves divide the tread into two outer circumferential ribs and two inner circumferential ribs. A plurality of rib sipes are disposed on at least one circumferential rib. The tire includes a plurality of curvilinear spline sipes, wherein each curvilinear spline sipe has multiple inflection points. At least one curvilinear spline sipe is disposed on an outer circumferential rib and at least one curvilinear spline sipe is disposed on a different circumferential rib. A localized depth of the at least one curvilinear spline sipe disposed on the outer circumferential rib varies in proportion to the distance from the rib sipes that intersect the at least one curvilinear spline sipe.

Abstract: An apparatus and method are disclosed for modeling at least a portion of a rolling tire (200). A finite element model of at least a portion of a tire (200) rolling against a tire contacting surface (202, 506, 602) is input into a finite element analysis system (100). The system executed instructions that result in the application of a constant force to the model tire (200) or portion thereof by the tire contacting surface (202, 506, 602). The application of force control boundary conditions, as opposed to displacement control, provides significant benefit in terms of computational time of the finite element analysis solution. A finite element analysis simulation of the model against the tire contacting surface (202, 506, 602) is performed while maintaining the force on the model tire (200). Alternatively, a camber (?) is also applied to the tire and maintained throughout the simulation.

Abstract: An electrical connector assembly includes a receptacle, a first ground plane partitioning the receptacle, a plug configured to mate with the receptacle, and a second ground plane partitioning the plug. Each of the first and second ground planes are in mechanical and electrical contact with one another when the plug is mated to the receptacle.