Patents by Inventor Russell Digate

Russell Digate has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Complexation of fatty acid-conjugated molecules with albumin
    Patent number: 9309303
    Abstract: The present disclosure relates generally to novel methods and compositions for using engineered reprogramming factor(s) for the creation of induced pluripotent stem cells (iPSCs) through a kinetically controlled process. Specifically, this disclosure relates to establishing combinations of reprogramming factors, including fusions between conventional reprogramming factors with transactivation domains, optimized for reprogramming various types of cells. More specifically, the exemplary methods disclosed herein can be used for creating induced pluripotent stem cells from various mammalian cell types, including human fibroblasts. Exemplary methods of feeder-free derivation of human induced pluripotent stem cells using synthetic messenger RNA are also disclosed.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: April 12, 2016
    Assignee: The University of the Sciences in Philadelphia
    Inventors: Zhlyu Li, Russell Digate
  • Complexation of Fatty Acid-Conjugated Molecules with Albumin
    Publication number: 20140286863
    Abstract: The present disclosure relates generally to novel methods and compositions for using engineered reprogramming factor(s) for the creation of induced pluripotent stem cells (iPSCs) through a kinetically controlled process. Specifically, this disclosure relates to establishing combinations of reprogramming factors, including fusions between conventional reprogramming factors with transactivation domains, optimized for reprogramming various types of cells. More specifically, the exemplary methods disclosed herein can be used for creating induced pluripotent stem cells from various mammalian cell types, including human fibroblasts. Exemplary methods of feeder-free derivation of human induced pluripotent stem cells using synthetic messenger RNA are also disclosed.
    Type: Application
    Filed: December 3, 2013
    Publication date: September 25, 2014
    Applicant: The University of the Sciences in Philadelphia
    Inventors: Zhlyu LI, Russell DIGATE
  • Complexation of fatty acid-conjugated molecules with albumin
    Patent number: 8598311
    Abstract: The technology described herein is directed to conjugating various therapeutic or functional molecules, such small chemical drugs, peptides, oligonucleotides, isotopes and imaging regents with fatty acids, such as LCFAs. The fatty acid-conjugated molecules are complexed with a human serum albumin protein in vitro.
    Type: Grant
    Filed: November 20, 2008
    Date of Patent: December 3, 2013
    Assignee: The University of the Sciences in Philadelphia
    Inventors: Zhlyu Li, Russell Digate
  • COMPLEXATION OF FATTY ACID-CONJUGATED MOLECULES WITH ALBUMIN
    Publication number: 20100272644
    Abstract: The technology described herein is directed to conjugating various therapeutic or functional molecules, such small chemical drugs, peptides, oligonucleotides, isotopes and imaging regents with fatty acids, such as LCFAs. The fatty acid-conjugated molecules are complexed with a human serum albumin protein in vitro.
    Type: Application
    Filed: November 20, 2008
    Publication date: October 28, 2010
    Applicant: The University of the Sciences in Philadelphia
    Inventors: Zhlyu Li, Russell Digate