Patents by Inventor Russell F. Bey
Russell F. Bey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10996222Abstract: This disclosure presents an Enzyme-Linked Immunosorbent Assay (ELISA) for the selective detection of anti-Mycoplasma hyorhinis IgG in porcine serum, which may contain antibodies specific to multiple other Mycoplasma spp.Type: GrantFiled: December 7, 2015Date of Patent: May 4, 2021Assignee: Boehringer Ingelheim Animal Health USA Inc.Inventors: Paulraj Lawrence, Russell F. Bey, Mike Stoll, Eric Bumgardner, Douglas Stine
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Patent number: 10603371Abstract: The present invention provides attenuated P. multocida strains that elicit an immune response in animal P. multocida, compositions comprising said strains, methods of vaccination against P. multocida, and kits for use with such methods and compositions. The invention further provides novel, genetically-engineered mutations in P. multocida hyaD and nanPU genes, which are useful in the production of novel attenuated P. multocida bacterial strains.Type: GrantFiled: August 4, 2017Date of Patent: March 31, 2020Assignee: BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.Inventors: Paulraj Kirubakaran Lawrence, Russell F. Bey, Randy R. Simonson
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Patent number: 10058601Abstract: The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.Type: GrantFiled: May 12, 2017Date of Patent: August 28, 2018Assignee: MERIAL INC.Inventors: Russell F. Bey, Paulraj Kirubakaran Lawrence, Randy R. Simonson
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Publication number: 20180015157Abstract: The present invention provides attenuated P. multocida strains that elicit an immune response in animal P. multocida, compositions comprising said strains, methods of vaccination against P. multocida, and kits for use with such methods and compositions. The invention further provides novel, genetically-engineered mutations in P. multocida hyaD and nanPU genes, which are useful in the production of novel attenuated P. multocida bacterial strains.Type: ApplicationFiled: August 4, 2017Publication date: January 18, 2018Applicant: MERIAL INC.Inventors: Paulraj Kirubakaran Lawrence, Russell F. Bey, Randy R. Simonson
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Publication number: 20170363622Abstract: This disclosure presents an Enzyme-Linked Immunosorbent Assay (ELISA) for the selective detection of anti-Mycoplasma hyorhinis IgG in porcine serum, which may contain antibodies specific to multiple other Mycoplasma spp.Type: ApplicationFiled: December 7, 2015Publication date: December 21, 2017Applicant: MERIAL INC.Inventors: Paulraj Lawrence, Russell F. Bey, Mike Stoll, Eric Bumgardner, Douglas Stine
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Patent number: 9757445Abstract: The present invention provides attenuated P. multocida strains that elicit an immune response in animal P. multocida, compositions comprising said strains, methods of vaccination against P. multocida, and kits for use with such methods and compositions. The invention further provides novel, genetically-engineered mutations in P. multocida hyaD and nanPU genes, which are useful in the production of novel attenuated P. multocida bacterial strains.Type: GrantFiled: October 30, 2014Date of Patent: September 12, 2017Assignee: MERIAL INC.Inventors: Paulraj Kirubakaran Lawrence, Russell F. Bey
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Publication number: 20170246286Abstract: The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.Type: ApplicationFiled: May 12, 2017Publication date: August 31, 2017Applicant: MERIAL INC.Inventors: Russell F. Bey, Paulraj Kirubakaran Lawrence, Randy R. Simonson
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Patent number: 9675682Abstract: The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.Type: GrantFiled: January 8, 2016Date of Patent: June 13, 2017Assignee: MERIAL, INC.Inventors: Russell F. Bey, Paulraj Kirubakaran Lawrence, Randy R. Simonson
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Patent number: 9504740Abstract: The present invention is a Haemophilus parasuis vaccine against serovar type 4 capable of triggering a protective immune response when administered to pigs as a killed vaccine. The present invention is also a method for vaccinating swine against Haemophilus parasuis infection, serovar type 4, by a) clonally propagating one or more cells which are capable of triggering an immune response against Haemophilus parasuis infection, serovar type 4, that protects the pig against Haemophilus parasuis infection, and b) combining an immunologically effective amount of the cells with a veterinarily acceptable carrier in a form suitable for administration as a vaccine to the pig, and c) administering as a killed vaccine. The cell culture is from a pathogenic parent strain.Type: GrantFiled: October 6, 2014Date of Patent: November 29, 2016Assignee: MERIAL, INC.Inventors: Paulraj Kirubakaran Lawrence, Russell F. Bey
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Patent number: 9446117Abstract: The present invention provides Rotavirus antigenic polypeptides or antigens that elicit an immune response in animal or human against rotavirus, compositions comprising said rotavirus polypeptides, methods of vaccination against rotavirus, and kits for use with such methods and compositions. The invention further provide novel expression vectors for producing the vaccine antigenic polypeptides.Type: GrantFiled: February 14, 2013Date of Patent: September 20, 2016Assignee: Merial, Inc.Inventors: Russell F. Bey, Randy S Simonson, Kamesh Reddy Sirigireddy, Benjamin Matthew Hause
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Publication number: 20160199477Abstract: The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.Type: ApplicationFiled: January 8, 2016Publication date: July 14, 2016Applicant: Merial Inc.Inventors: Russell F. Bey, Paulraj Kirubakaran Lawrence, Randy R. Simonson
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Patent number: 9370561Abstract: The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.Type: GrantFiled: November 8, 2013Date of Patent: June 21, 2016Assignee: MERIAL, INC.Inventors: Russell F. Bey, Paulraj Kirubakaran Lawrence, Randy R. Simonson
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Publication number: 20160158336Abstract: The present invention provides attenuated M. haemolytica strains that elicit an immune response in animals against M. haemolytica, compositions comprising said strains, methods of vaccination against M. haemolytica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.Type: ApplicationFiled: November 6, 2015Publication date: June 9, 2016Inventors: Russell F Bey, Paulraj Kirubakaran Lawrence, Randy R Simonson, Robert E Briggs, Fred M Tatum
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Patent number: 9289484Abstract: The present invention provides attenuated S. suis strains that elicit an immune response in animals against S. suis, compositions comprising said strains, methods of vaccination against S. suis, and kits for use with such methods and compositions. The invention further provides novel, mutagenically-induced mutations in S. suis genes, which are useful in the production of novel attenuated S. suis bacterial strains.Type: GrantFiled: June 24, 2013Date of Patent: March 22, 2016Assignee: MERIAL, INC.Inventors: Russell F Bey, Paulraj Kirubakaran Lawrence, Randy R Simonson, Kamesh Reddy Sirigireddy, Danielle A McKeown
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Patent number: 9132183Abstract: The present invention is a live vaccine from a culture of cells of Haemophilus parasuis exhibiting attenuated pathogenicity and capable of triggering a protective immune response when administered to pigs. The cell culture was modified from a pathogenic parent strain by MNNG mutagenesis and was selected by complete dependence on streptomycin for growth. Several SNPs have been identified as associated with specific proteins that are associated with virulence as seen in the literature in H. parasuis or related bacterial species.Type: GrantFiled: February 13, 2012Date of Patent: September 15, 2015Assignee: NEWPORT LABORATORIESInventors: Kamesh R. Sirigireddy, Paulraj K. Lawrence, Russell F. Bey, Randy R. Simonson
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Publication number: 20150125487Abstract: The present invention provides attenuated P. multocida strains that elicit an immune response in animal P. multocida, compositions comprising said strains, methods of vaccination against P. multocida, and kits for use with such methods and compositions. The invention further provides novel, genetically-engineered mutations in P. multocida hyaD and nanPU genes, which are useful in the production of novel attenuated P. multocida bacterial strains.Type: ApplicationFiled: October 30, 2014Publication date: May 7, 2015Applicant: MERIAL LIMITEDInventors: Paulraj Kirubakaran Lawrence, Russell F. Bey
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Publication number: 20150098968Abstract: The present invention is a Haemophilus parasuis vaccine against serovar type 4 capable of triggering a protective immune response when administered to pigs as a killed vaccine. The present invention is also a method for vaccinating swine against Haemophilus parasuis infection, serovar type 4, by a) clonally propagating one or more cells which are capable of triggering an immune response against Haemophilus parasuis infection, serovar type 4, that protects the pig against Haemophilus parasuis infection, and b) combining an immunologically effective amount of the cells with a veterinarily acceptable carrier in a form suitable for administration as a vaccine to the pig, and c) administering as a killed vaccine. The cell culture is from a pathogenic parent strain.Type: ApplicationFiled: October 6, 2014Publication date: April 9, 2015Applicant: MERIAL LIMITEDInventors: Paulraj Kirubakaran Lawrence, Russell F. Bey
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Publication number: 20140170190Abstract: The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.Type: ApplicationFiled: November 8, 2013Publication date: June 19, 2014Applicant: MERIAL LIMITEDInventors: Russell F Bey, Paulraj Kirubakaran Lawrence, Randy R Simonson
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Publication number: 20140004144Abstract: The present invention provides attenuated S. suis strains that elicit an immune response in animal S. suis, compositions comprising said strains, methods of vaccination against S. suis, and kits for use with such methods and compositions. The invention further provides novel, mutagenically-induced mutations in S. suis genes, which are useful in the production of novel attenuated S. suis bacterial strains.Type: ApplicationFiled: June 24, 2013Publication date: January 2, 2014Applicant: MERIAL LIMITEDInventors: Russell F Bey, Paulraj Kirubakaran Lawrence, Randy R Simonson, Kamesh Reddy Sirigireddy, Danielle A McKeown
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Publication number: 20130209507Abstract: The present invention provides Rotavirus antigenic polypeptides or antigens that elicit an immune response in animal or human against rotavirus, compositions comprising said rotavirus polypeptides, methods of vaccination against rotavirus, and kits for use with such methods and compositions. The invention further provide novel expression vectors for producing the vaccine antigenic polypeptides.Type: ApplicationFiled: February 14, 2013Publication date: August 15, 2013Applicant: MERIAL LIMITEDInventors: Russell F. Bey, Randy S. Simonson, Kamesh Reddy Sirigireddy, Benjamin Matthew Hause