Patents by Inventor Russell Higuchi

Russell Higuchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INTEGRATED PURIFICATION AND MEASUREMENT OF DNA METHYLATION AND CO-MEASUREMENT OF MUTATIONS AND/OR MRNA EXPRESSION LEVELS IN AN AUTOMATED REACTION CARTRIDGE
    Publication number: 20240141415
    Abstract: In various embodiments methods of determining methylation of DNA are provided.
    Type: Application
    Filed: January 11, 2023
    Publication date: May 2, 2024
    Applicant: Cepheid
    Inventors: Edwin Wei-Lung Lai, Andrew Kohlway, Reuel Van Atta, Russell Higuchi, Alexander A. Gall, Kriszten Kocmond
  • Exponential base-greater-than-2 nucleic acid amplification
    Patent number: 11952621
    Abstract: Described herein are methods and compositions that provide highly efficient nucleic acid amplification. In some embodiments, this allows a greater than 2-fold increase of amplification product for each amplification cycle and therefore increased sensitivity and speed over conventional PCR.
    Type: Grant
    Filed: May 3, 2021
    Date of Patent: April 9, 2024
    Assignee: CEPHEID
    Inventor: Russell Higuchi
  • PSEUDO-COMPLEMENTARY BASES IN GENOTYPING AND NUCLEIC ACID SEQUENCING
    Publication number: 20230167490
    Abstract: Described herein are methods and compositions that make use of pseudo-complementary bases to reduce unwanted hybridization in assays to detect and/or quantify particular nucleotide sequences, as well as in nucleic acid sequencing protocols.
    Type: Application
    Filed: April 27, 2021
    Publication date: June 1, 2023
    Applicant: Cepheid
    Inventors: Russell Higuchi, Nicholas Wang
  • EXPONENTIAL BASE-3 AND GREATER NUCLEIC ACID AMPLIFICATION WITH REDUCED AMPLIFICATION TIME
    Publication number: 20230096557
    Abstract: Described herein are methods and compositions that provide highly efficient nucleic acid amplification. In some embodiments, this allows a 3-fold or greater increase of amplification product for each amplification cycle and therefore increased sensitivity and speed over conventional PCR. Modified bases can be employed in primers to provide this base-3 or greater amplification with satisfactory PCR cycle times, which are improved, as compared to those observed in the absence of modified bases.
    Type: Application
    Filed: May 5, 2022
    Publication date: March 30, 2023
    Applicant: Cepheid
    Inventor: Russell Higuchi
  • Integrated purification and measurement of DNA methylation and co-measurement of mutations and/or MRNA expression levels in an automated reaction cartridge
    Patent number: 11603555
    Abstract: In various embodiments methods of determining methylation of DNA are provided.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: March 14, 2023
    Assignee: CEPHEID
    Inventors: Edwin W. Lai, Andrew Kohlway, Reuel Vanatta, Russell Higuchi, Alexander Gall, Kriszten Kocmond
  • INTEGRATED PURIFICATION AND MEASUREMENT OF DNA METHYLATION AND CO-MEASUREMENT OF MUTATIONS AND/OR MRNA EXPRESSION LEVELS IN AN AUTOMATED REACTION CARTRIDGE
    Publication number: 20220226809
    Abstract: Methods of determining methylation of DNA are provided.
    Type: Application
    Filed: January 27, 2022
    Publication date: July 21, 2022
    Applicant: Cepheid
    Inventors: Edwin Wei-Lung Lai, Andrew Kohlway, Reuel Van Atta, Russell Higuchi, Alexander A. Gall, Kriszten Kocmond
  • Exponential base-3 and greater nucleic acid amplification with reduced amplification time
    Patent number: 11352622
    Abstract: Described herein are methods and compositions that provide highly efficient nucleic acid amplification. In some embodiments, this allows a 3-fold or greater increase of amplification product for each amplification cycle and therefore increased sensitivity and speed over conventional PCR. Modified bases can be employed in primers to provide this base-3 or greater amplification with satisfactory PCR cycle times, which are improved, as compared to those observed in the absence of modified bases.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: June 7, 2022
    Assignee: CEPHEID
    Inventor: Russell Higuchi
  • Integrated purification and measurement of DNA methylation and co-measurement of mutations and/or mRNA expression levels in an automated reaction cartridge
    Patent number: 11260387
    Abstract: Methods of determining methylation of DNA are provided.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: March 1, 2022
    Assignee: CEPHEID
    Inventors: Edwin Wei-Lung Lai, Andrew Kohlway, Reuel Van Atta, Russell Higuchi, Alexander A. Gall, Kriszten Kocmond
  • EXPONENTIAL BASE-3 AND GREATER NUCLEIC ACID AMPLIFICATION WITH CYCLING PROBE
    Publication number: 20210403981
    Abstract: Described herein are methods and compositions that provide highly efficient nucleic acid amplification and signal detection using a cycling probe. In some embodiments, this allows a 3-fold or greater increase of amplification product for each amplification cycle and therefore increased sensitivity and speed over conventional PCR. Modified bases can be employed in primers to provide this base-3 or greater amplification with satisfactory PCR cycle times, which are improved, as compared to those observed in the absence of modified bases.
    Type: Application
    Filed: April 26, 2021
    Publication date: December 30, 2021
    Inventors: Russell Higuchi, Sergey G. Lokhov, Victoria Le, Benjamin Pavlik, Gongbo Wang
  • EXPONENTIAL BASE-GREATER-THAN-2 NUCLEIC ACID AMPLIFICATION
    Publication number: 20210395797
    Abstract: Described herein are methods and compositions that provide highly efficient nucleic acid amplification. In some embodiments, this allows a greater than 2-fold increase of amplification product for each amplification cycle and therefore increased sensitivity and speed over conventional PCR.
    Type: Application
    Filed: May 3, 2021
    Publication date: December 23, 2021
    Inventor: Russell Higuchi
  • Exponential base-greater-than-2 nucleic acid amplification
    Patent number: 11028434
    Abstract: Described herein are methods and compositions that provide highly efficient nucleic acid amplification. In some embodiments, this allows a greater than 2-fold increase of amplification product for each amplification cycle and therefore increased sensitivity and speed over conventional PCR.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: June 8, 2021
    Assignee: CEPHEID
    Inventor: Russell Higuchi
  • EXPONENTIAL BASE-3 AND GREATER NUCLEIC ACID AMPLIFICATION WITH REDUCED AMPLIFICATION TIME
    Publication number: 20200239878
    Abstract: Described herein are methods and compositions that provide highly efficient nucleic acid amplification. In some embodiments, this allows a 3-fold or greater increase of amplification product for each amplification cycle and therefore increased sensitivity and speed over conventional PCR. Modified bases can be employed in primers to provide this base-3 or greater amplification with satisfactory PCR cycle times, which are improved, as compared to those observed in the absence of modified bases.
    Type: Application
    Filed: October 29, 2019
    Publication date: July 30, 2020
    Applicant: Cepheid
    Inventor: Russell Higuchi
  • Methods of Detecting Bladder Cancer
    Publication number: 20190382847
    Abstract: Compositions and methods for detecting bladder cancer are provided. In some embodiments, methods of detecting low grade bladder cancer are provided. In some embodiments, methods of monitoring recurrence of bladder cancer are provided. In some embodiments, the methods comprise detecting androgen receptor (AR) and/or uroplakin 1B (UPK1B).
    Type: Application
    Filed: May 14, 2019
    Publication date: December 19, 2019
    Applicant: Cepheid
    Inventors: Leena McCann, Stacey Ellen Wallace, Edwin Wei-Lung Lai, Russell Higuchi
  • Methods of Detecting Bladder Cancer
    Publication number: 20190360050
    Abstract: Compositions and methods for detecting bladder cancer are provided. In some embodiments, methods of monitoring recurrence of bladder cancer are provided. In some embodiments, the methods comprise detecting a set of markers consisting of CRH, IGF2, KRT20, and ANXA10.
    Type: Application
    Filed: February 11, 2019
    Publication date: November 28, 2019
    Inventors: Russell Higuchi, Stacey Ellen Wallace, Edwin Wei-Lung Lai
  • EXPONENTIAL BASE-GREATER-THAN-2 NUCLEIC ACID AMPLIFICATION
    Publication number: 20190203266
    Abstract: Described herein are methods and compositions that provide highly efficient nucleic acid amplification. In some embodiments, this allows a greater than 2-fold increase of amplification product for each amplification cycle and therefore increased sensitivity and speed over conventional PCR.
    Type: Application
    Filed: March 20, 2019
    Publication date: July 4, 2019
    Inventor: Russell Higuchi
  • Methods of detecting bladder cancer
    Patent number: 10329622
    Abstract: Compositions and methods for detecting bladder cancer are provided. In some embodiments, methods of detecting low grade bladder cancer are provided. In some embodiments, methods of monitoring recurrence of bladder cancer are provided. In some embodiments, the methods comprise detecting androgen receptor (AR) and/or uroplakin 1B (UPK1B).
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: June 25, 2019
    Assignee: Cepheid
    Inventors: Leena McCann, Stacey Ellen Wallace, Edwin Wei-Lung Lai, Russell Higuchi
  • Exponential base-greater-than-2 nucleic acid amplification
    Patent number: 10273534
    Abstract: Described herein are methods and compositions that provide highly efficient nucleic acid amplification. In some embodiments, this allows a greater than 2-fold increase of amplification product for each amplification cycle and therefore increased sensitivity and speed over conventional PCR.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: April 30, 2019
    Assignee: CEPHEID
    Inventor: Russell Higuchi
  • Compositions and methods for detecting markers associated with bladder cancer
    Patent number: 10202653
    Abstract: Compositions and methods for detecting bladder cancer are provided. In some embodiments, methods of monitoring recurrence of bladder cancer are provided. In some embodiments, the methods comprise detecting a set of markers consisting of CRH, IGF2, KRT20, and ANXA10.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: February 12, 2019
    Assignee: Cepheid
    Inventors: Russell Higuchi, Stacey Ellen Wallace, Edwin Wei-Lung Lai
  • INTEGRATED PURIFICATION AND MEASUREMENT OF DNA METHYLATION AND CO-MEASUREMENT OF MUTATIONS AND/OR MRNA EXPRESSION LEVELS IN AN AUTOMATED REACTION CARTRIDGE
    Publication number: 20180214864
    Abstract: Methods of determining methylation of DNA are provided.
    Type: Application
    Filed: December 12, 2017
    Publication date: August 2, 2018
    Inventors: EDWIN WEI-LUNG LAI, ANDREW KOHLWAY, REUEL VAN ATTA, RUSSELL HIGUCHI, ALEXANDER A. GALL, KRISZTEN KOCMOND
  • EXPONENTIAL BASE-GREATER-THAN-2 NUCLEIC ACID AMPLIFICATION
    Publication number: 20180066304
    Abstract: Described herein are methods and compositions that provide highly efficient nucleic acid amplification. In some embodiments, this allows a greater than 2-fold increase of amplification product for each amplification cycle and therefore increased sensitivity and speed over conventional PCR.
    Type: Application
    Filed: December 15, 2015
    Publication date: March 8, 2018
    Inventor: Russell HIGUCHI