Abstract: A blister package for a contact lens is provided. A deformable slider supporting a lens is movable via pull-tab or hinge to lift the contact lens out of a lens well. The deformable slider can include a hinge connected to a flexible peel-away top of the blister package or connected to a pull tab that can be pulled to pull taut the deformable slider. A blister package is also provided that includes a hinged shell having a lateral opening opposite the hinge, and a deformable slider that is folded over onto itself and seals both a top chamber and a bottom chamber. By pulling a tongue of the deformable slider, which extends from the lateral opening, the deformable slider can be removed from the closed shell and the closed shell can be opened enabling access to the contact lens.

Abstract: Compounds, compositions, and methods related to bioenergetic metabolism are provided. The compounds and compositions are suited to promote bioenergetic processes including cellular respiration and glycolytic flux and may be used to treat mitochondrial disorders, neurodegenerative diseases (such as Alzheimer's disease (AD), Parkinson's disease, and/or amyotrophic lateral sclerosis), multiple sclerosis, and/or epilepsy.

Abstract: Systems and methods for streaming of multimedia files over a network are described. A streaming delivery accelerator (SDA) caches content from a content provider and streams the cached content to a user. Cached content is incrementally added to the cache memory, and the SDA is disconnected from the content provider when sufficient content for a predetermined time of play has been received. The caching process can be iterative, with only content not previously retained in the cache requested from the content provider. A method for cache eviction of content no longer of interest to users is also described.

Abstract: The use of a compound comprising formula (I), or a salt, ester, amide or prodrug thereof in the treatment of obesity and related disorders. The invention also relates to novel compounds within formula (I), to processes for preparing them and pharmaceutical compositions containing them. In formula (I): A is an optionally substituted thienyl moiety, Y is O, S, or NR2, R1 is a branched or unbranched alkyl (optionally interrupted by one or more oxygen atoms), alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, reduced arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, reduced aryl, reduced heteroaryl, reduced heteroarylalkyl or a substituted derivative of any of the foregoing groups and R2 is hydrogen or a group as defined for R1.

Abstract: Systems and methods for streaming of multimedia files over a network are described. A streaming delivery accelerator (SDA) receives content from a content provider and streams the receives content to a user when a quality metric exceeds a predetermined value. A similar quality metric applies to caching and storing the received content in the SDA' cache. The caching process can be iterative, with only content not previously retained in the SDA's cache being requested from and retransmitted by the content provider.

Abstract: Systems and methods for streaming of multimedia files over a network are described. A streaming delivery accelerator (SDA) caches content from a content provider and streams the cached content to a user. Cached content is streamed when a quality metric exceeds a predetermined value that can depend on the transmission bandwidth to the user. The caching process can be iterative, with only content not previously retained in the cache requested from the content provider. Systems and methods for effective cache management are also described.

Abstract: Systems and methods for streaming of multimedia files over a network are described. A streaming delivery accelerator (SDA) caches content from a content provider and streams the cached content to a user. Cached content is incrementally added to the cache memory, and the SDA is disconnected from the content provider when sufficient content for a predetermined time of play has been received. The caching process can be iterative, with only content not previously retained in the cache requested from the content provider. A method for cache eviction of content no longer of interest to users is also described.