Patents by Inventor Russell J. Composto

Russell J. Composto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small Diameter Vascular Graft Produced by a Hybrid Method
    Publication number: 20150359619
    Abstract: The present invention relates to a hybrid graft and methods of generating the hybrid graft. The hybrid graft comprises an exterior surface and a luminal surface. The luminal surface comprises a micropattern of grooves to which cells adhere and orient along. The exterior surface comprises electrospun microfibers wherein the microfibers provide mechanical properties to the graft. The hybrid graft is capable supporting endothelial cell attachment, endothelial cell alignment, cell proliferation, and maintaining their in vivo function. The graft of the invention can recapitulate the in vivo morphology and function of natural vascular endothelium.
    Type: Application
    Filed: July 10, 2015
    Publication date: December 17, 2015
    Inventors: Peter I. Lelkes, Mengyan Li, Anat Perets, Pimporn Uttayarat, Robert J. Levy, Russell J. Composto
  • Small diameter vascular graft produced by a hybrid method
    Patent number: 9107739
    Abstract: The present invention relates to a hybrid graft and methods of generating the hybrid graft. The hybrid graft comprises an exterior surface and a luminal surface. The luminal surface comprises a micropattern of grooves to which cells adhere and orient along. The exterior surface comprises electrospun microfibers wherein the microfibers provide mechanical properties to the graft. The hybrid graft is capable supporting endothelial cell attachment, endothelial cell alignment, cell proliferation, and maintaining their in vivo function. The graft of the invention can recapitulate the in vivo morphology and function of natural vascular endothelium.
    Type: Grant
    Filed: November 24, 2010
    Date of Patent: August 18, 2015
    Assignees: Drexel University, The Children's Hospital of Philadelphia, The Trustees of the University of Pennsylvania
    Inventors: Peter I. Lelkes, Mengyan Li, Anat Perets, Pimporn Uttayarat, Robert J. Levy, Russell J. Composto
  • Small Diameter Vascular Graft Produced by a Hybrid Method
    Publication number: 20130018454
    Abstract: The present invention relates to a hybrid graft and methods of generating the hybrid graft. The hybrid graft comprises an exterior surface and a luminal surface. The luminal surface comprises a micropattern of grooves to which cells adhere and orient along. The exterior surface comprises electrospun microfibers wherein the microfibers provide mechanical properties to the graft. The hybrid graft is capable supporting endothelial cell attachment, endothelial cell alignment, cell proliferation, and maintaining their in vivo function. The graft of the invention can recapitulate the in vivo morphology and function of natural vascular endothelium.
    Type: Application
    Filed: November 24, 2010
    Publication date: January 17, 2013
    Inventors: Peter I. Lelkes, Mengyan Li, Anat Perets, Pimporn Uttayarat, Robert J. Levy, Russell J. Composto