Patents by Inventor Russell-John Krom

Russell-John Krom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineered phagemids
    Patent number: 11473104
    Abstract: Provided herein, in some embodiments, are engineered phagemids that comprise at least one synthetic genetic circuit, wherein the at least one synthetic genetic circuit comprises gene sequences encoding at least one non-lytic antimicrobial peptides (AMPs) and/or antibacterial toxin proteins, a stable origin of replication, and a bacteriophage-packaging signal, wherein the engineered phagemid does not comprise some or all gene sequences encoding bacteriophage proteins required for assembly of a bacteriophage particle.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: October 18, 2022
    Assignees: Massachusetts Institute of Technology, Trustees of Boston University, President and Fellows of Harvard College
    Inventors: Russell-John Krom, James J. Collins, Prerna Saluja Bhargava, Michael Andrew Lobritz
  • FUNCTIONALIZATION OF ENDOGENOUS BACTERIA
    Publication number: 20220033830
    Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.
    Type: Application
    Filed: March 1, 2021
    Publication date: February 3, 2022
    Applicants: Trustees of Boston University, Massachusetts Institute of Technology
    Inventors: Timothy Kuan-Ta Lu, Robert James Citorik, James Collins, Russell-John Krom
  • Functionalization of endogenous bacteria
    Patent number: 10968454
    Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: April 6, 2021
    Assignees: Massachusetts Institute of Technology, Trustees of Boston University
    Inventors: Timothy Kuan-Ta Lu, Robert James Citorik, James Collins, Russell-John Krom
  • ENGINEERED PHAGEMIDS
    Publication number: 20180355378
    Abstract: Provided herein, in some embodiments, are engineered phagemids that comprise at least one synthetic genetic circuit, wherein the at least one synthetic genetic circuit comprises gene sequences encoding at least one non-lytic antimicrobial peptides (AMPs) and/or antibacterial toxin proteins, a stable origin of replication, and a bacteriophage-packaging signal, wherein the engineered phagemid does not comprise some or all gene sequences encoding bacteriophage proteins required for assembly of a bacteriophage particle.
    Type: Application
    Filed: December 4, 2015
    Publication date: December 13, 2018
    Applicants: Massachusetts Institute of Technology, Trustees of Boston University, President and Fellows of Harvard College
    Inventors: Russell-John KROM, James J. COLLINS, Prerna Saluja BHARGAVA, Michael Andrew LOBRITZ
  • FUNCTIONALIZATION OF ENDOGENOUS BACTERIA
    Publication number: 20180305703
    Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.
    Type: Application
    Filed: March 16, 2018
    Publication date: October 25, 2018
    Applicants: Trustees of Boston University, Massachusetts Institute of Technology
    Inventors: Timothy Kuan-Ta Lu, Robert James Citorik, James Collins, Russell-John Krom
  • Functionalization of endogenous bacteria
    Patent number: 9957511
    Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: May 1, 2018
    Assignees: Massachusetts Institute of Technology, Trustees of Boston University
    Inventors: Timothy Kuan-Ta Lu, Robert James Citorik, James Collins, Russell-John Krom
  • FUNCTIONALIZATION OF ENDOGENOUS BACTERIA
    Publication number: 20150004705
    Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.
    Type: Application
    Filed: July 1, 2014
    Publication date: January 1, 2015
    Applicants: Massachusetts Institute of Technology, Trustees of Boston University
    Inventors: Timothy Kuan-Ta Lu, Robert James Citorik, James Collins, Russell-John Krom