Abstract: An example method of determining operational health of a virtualized computing system includes: monitoring, at a service executing in the virtualized computing system, a current configuration of a software-defined data center (SDDC) with respect to a desired state, the desired state including: a host cluster having hosts executing a virtualization layer thereon; a software-defined (SD) network deployed in the host cluster; shared storage accessible by the host cluster; a virtual infrastructure (VI) control plane managing the host cluster, the SD network, and the shared storage; and an orchestration control plane integrated with the virtualization layer and the VI control plane; determining a configuration status for the current configuration of the SDDC; monitoring, at the service, operational status of an application management system executing on the SDDC having the current configuration; and determining at least one measure of the operational health in response to the configuration status and the operation

Abstract: An example virtualized computing system includes a host cluster having a virtualization layer directly executing on hardware platforms of hosts, the virtualization layer supporting execution of virtual machines (VMs), the VMs including pod VMs, the pod VMs including container engines supporting execution of containers in the pod VMs; an orchestration control plane integrated with the virtualization layer, the orchestration control plane including a master server and pod VM controllers, the pod VM controllers executing in the virtualization layer external to the VMs, the pod VM controllers configured as agents of the master server to manage the pod VMs; pod VM agents, executing in the pod VMs, configured as agents of the pod VM controllers to manage the containers executing in the pod VMs.

Abstract: A container image registry is managed in a virtualized computing system. The container image registry manages container images for deploying containers in a host cluster, the host cluster includes hosts and a virtualization layer executing on hardware platforms of the hosts, and the virtualization layer supports execution of virtual machines (VMs). The method includes: creating a namespace for an orchestration control plane integrated with the virtualization layer, the namespace including constraints for deploying workloads in the VMs; invoking, by a registry service in response to creation of the namespace, a management application programming interface (API) of the container image registry to create a project for the container images; and invoking, by the registry service, the management API of the container image registry to both add members to the project, and assign image registry roles to the members, in response to bindings of users and namespace roles derived from the constraints.

Abstract: An example virtualized computing system includes: a host cluster having hosts and a virtualization layer executing on hardware platforms of the hosts, the virtualization layer supporting execution of virtual machines (VMs); an orchestration control plane integrated with the virtualization layer, the orchestration control plane including a master server executing in a first VM of the VMs; guest cluster infrastructure software (GCIS) executing in the master server, the GCIS configured to create a set of objects defining a container orchestration cluster, and manage lifecycles of second VMs of the VMs based on state of the set of objects; and guest software executing in the second VMs to implement the container orchestration cluster as a guest cluster of the host cluster, the guest software having components that interface with the GCIS.

Abstract: An example method of managing an application in a virtualized computing system that includes a cluster of hosts managed by a virtualization management server, the hosts including a virtualization layer executing on hardware platforms is described.

Abstract: An example method of checking compatibility of a guest cluster executing as a virtual extension of a host cluster having an orchestration control plane managing the guest cluster, the host cluster being part of a software defined data center (SDDC), is described.

Abstract: Container images are managed in a clustered container host system with a shared storage device. Hosts of the system include a virtualization software layer that supports execution of virtual machines (VMs) in the hosts, and one or more VMs have implemented therein a container engine that supports execution of containers within the respective VMs. Deploying a container in a first VM includes creating a virtual disk in the storage device, storing a container image in the virtual disk, mounting the virtual disk to the first VM, and updating a metadata cache to associate the container image to the virtual disk. Deploying the container in a second VM executed in a host different from a host in which the first VM is executed, includes checking the metadata cache to determine that the container image is stored in the virtual disk, and mounting the virtual disk to the second VM.

Abstract: Servers and methods for determining geo-relevant interactive assets are provided. A server and method can be configured to determine a starting location, a direction, and a speed of travel. The server can then calculate future location information, and use the future location information to filter one or more geo-relevant interactive assets. Filtered geo-relevant interactive assets can be added to a map, and current location information can be determined. Geo-relevant interactive assets can be played or displayed according to the current location information.

Abstract: Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by dysregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.

Abstract: Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.

Abstract: Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.

Abstract: Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.

Abstract: Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.

Abstract: Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.

Abstract: A fluid collection system includes a disposable collection container configured to receive a disposable collection container. The fluid collection container may include a flexible liner configured to collapse during evacuation of the fluid from the liner. The system may include a receiving housing sized to receive the disposable collection container, the receiving housing including a cavity and a piston assembly positioned within the cavity, the piston including a piston check valve. The system includes a suction source connectable to the disposable collection container and a filter positioned between the suction source and the cavity. A first connecting line extends between a suction source opening, configured to communicate the suction source to the disposable collection container, and the filter. A first check valve connects to the first connecting line between the suction source opening and the filter.

Abstract: Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.

Abstract: Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.

Abstract: Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by dysregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.

Abstract: Apparatus and methods for an adjustable plant support comprising a plurality of modular components that can be arranged in various configurations and dimensions to accommodate different sized and shaped plants, and can be adjusted over time in relation to the plant and its growth or other changes. When assembled, the plant support creates a dynamic frame for supporting a plant over its life and/or guiding the direction of growth of a plant and/or limiting its growth in one or more directions.

Abstract: Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.