Abstract: Disclosed herein are novel cycloalka[b]heteroaryl compounds having CX3CR1/fractalkine receptor (CX3CR1) agonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with CX3CR1 receptor activity in animals, in particular humans.

Abstract: A heating apparatus, in particular for recreational vehicles like campers or caravans, comprises a heating unit and at least one heat exchanging unit coupled to the heating unit. The heating unit comprises at least one burner and at least one combustion air fan unit. The combustion air fan unit is configured to supply the burner with combustion air. The burneris configured to burn fuel gas or liquid further supplied to the burnertogether with the combustion air received from the combustion air fan unitto get hot exhaust gasses. The heat exchanging unitis configured to receive the exhaust gasses from the burnerand to transfer heat from the exhaust gasses to a fluid to be heated, provided within the heat exchanging unit. The burnercomprises at least two nozzles configured to supply fuel gas or liquid to a combustion area in which the fuel gas or liquid is to be burned with the combustion air.

Abstract: A heating apparatus, in particular for recreational vehicles like campers or caravans, comprises a heating unit and two separate heat exchanging units, which are coupled to the heating unit in parallel with each other. The heating unit comprises one burner for each heat exchanging unit, and at least one combustion air fan unit configured to supply the burners with combustion air. The burners are configured to burn fuel gas or liquid further supplied to each of the burners together with the combustion air received from the combustion air fan unit to get hot exhaust gasses. The heat exchanging units and are configured to receive the exhaust gasses from the burners, and to transfer heat from the exhaust gasses to fluids to be heated, provided within the heat exchanging units. The heat exchanging units are positioned in parallel with each other side by side on one side of the heating unit. Furthermore, the present invention refers to a recreational vehicle with such a heating apparatus.

Abstract: A heating apparatus, in particular for recreational vehicles like campers or caravans, comprises a heating unit and two separate heat exchanging units, which are coupled to the heating unit in parallel with each other. The heating unit comprises one burner for each heat exchanging unit and one common single combustion air fan unit. The single combustion air fan unit is configured to supply both burners with combustion air, and the burners are configured to burn fuel gas or liquid further supplied to each of the burners together with the combustion air received from the single combustion air fan unit to get hot exhaust gasses. The heat exchanging units are configured to receive the exhaust gasses from the burners, and to transfer heat from the exhaust gasses to fluids to be heated, provided within the heat exchanging units. Furthermore, the present invention refers to a recreational vehicle with such a heating apparatus and methods for heating two distinct fluids with the above heating apparatus.

Abstract: A probe system for facilitating inspection of a device under test comprising a plurality of panels, the probe system incorporating: a configurable universal probe bar comprising a plurality of probe blocks, the plurality of probe blocks comprising a plurality of probe pins positioned to simultaneously electrically engage a plurality of cell contact pads of the plurality of panels of the device under test to deliver a plurality of electrical test signals; and an alignment system configured to achieve an alignment of the plurality of probe pins with the plurality of the cell contact pads of the plurality of panels of the device under test.

Abstract: Communications are received from a transportation service provider and are parsed for data indicating capacity data. The data is then matched to a stored format for capacity data and the parsed data is extracted from the data matched to the stored format to a preferred data format, and reviewed to determine if the stored data reflects capacity indicated by the received communication. The data is then combined with preference data and performance data concerning the transportation service data and used to automatically match a demand for transportation services with the capacity to provide the transportation services.

Abstract: A fluid-fillable cushion comprises upper and lower layers, a first chamber and a second chamber and a discrete pressure distributing unit situated between the upper and lower layers, said pressure distributing unit providing a fluid connection between at least the first chamber and the second chamber. Such a cushion reduces leaks and allows controlled pressure equalisation between the chambers. Also disclosed is a process for making such cushions and seating products comprising such cushions.

Abstract: A mobile device (e.g., wireless wheeled vehicle) that includes one or more propulsion mechanisms (e.g., one or more drive wheels) and a member (e.g., a mechanized tail). The propulsion mechanism(s) are operable to propel the mobile device across a driving surface. The member is positionable to maintain or change an orientation of the mobile device with respect to the driving surface. The member has a base portion opposite a free end portion. The base portion is pivotably mounted to a portion of the mobile device. The base portion is pivotable to move the free end portion toward and away from the driving surface.

Abstract: Transportation services are matched with demand, in multiple segments in accordance with capabilities and business practices of a transportation service provider. A request for transportation services is received, including an origin, destination and a characterization of a load or service. Origin and destination geographical areas or locations are identified, and a main line segment and at least one distinct segment are identified to form a contiguous multi-segment routing. A transportation service provider is matched to the specified demand for transportation services, in order to comply with the scheduled sequence. One or more competitive bids are aggregated to provide a total bid price and provision of the transportation services are arranged using the candidate service interests winning the bid or bids.

Abstract: Communications are received from a transportation service provider and are parsed for data indicating capacity data. The data is then matched to a stored format for capacity data and the parsed data is extracted from the data matched to the stored format to a preferred data format, and reviewed to determine if the stored data reflects capacity indicated by the received communication. The data is then combined with preference data and performance data concerning the transportation service data and used to automatically match a demand for transportation services with the capacity to provide the transportation services.

Abstract: A method for treating type 1 and type 2 diabetes by administering an oral pharmaceutical formulation which comprises of insulin or its analogs amalgamated with suitable encapsulating agents and pharmaceutical excipients. The encapsulated pharmaceutical oral formulation protects insulin or its analogs from harsh milieu of the gastrointestinal tract and facilitates efficient delivery of insulin at targeted sites with sustained hypoglycemic activity.

Abstract: Transportation services are matched with a specified demand for transportation services. Categories of transportation services met by capabilities of the transportation service provider are determined, along with preference data concerning the transportation service provider, in which non-user-defined preference data is at least partially obtained by machine learning. Candidate service interest is used to match the transportation service provider to the specified demand for transportation services. Competitive bids are obtained to meet a specified demand for transportation services, and the transportation service provider is offered inclusion in the competitive bids based on the candidate service interest.

Abstract: A mobile device (e.g., wireless wheeled vehicle) that includes one or more propulsion mechanisms (e.g., one or more drive wheels) and a member (e.g., a mechanized tail). The propulsion mechanism(s) are operable to propel the mobile device across a driving surface. The member is positionable to maintain or change an orientation of the mobile device with respect to the driving surface. The member has a base portion opposite a free end portion. The base portion is pivotably mounted to a portion of the mobile device. The base portion is pivotable to move the free end portion toward and away from the driving surface.

Abstract: Matches for load or transportation services with transportation service providers (TSPs) are established, and estimated arrival times are provided. A transportation service request is arranged and an estimate of time of arrival is made based on an estimation of a time for performing a delivery of the load or provide the transportation service, and the time of arrival estimate is adjusted by at least one external factor expected to affect transit time. An anticipated turn-around time for availability of the TSP is made for a subsequent leg or backhaul and the adjusted time of arrival estimate and the anticipated turn-around time are used to estimate a time of availability of the TSP for the subsequent leg or backhaul. An accepted bid for the subsequent leg or backhaul is made based on an estimated time of availability.

Abstract: Matches for transportation services with transportation service providers (TSPs) and providing tracking are combined with an option for location tracking of the load or transportation service. Bids are accepted for transportation services and, on acceptance, a request is made for the TSP or driver “opt-in” to location tracking through a mobile device. The system automatically communicates with the driver to confirm acceptance of mobile telephone tracking (opt-in) and location tracking is initiated. The location is reported according to a threshold, along with updated estimates of pick-up and of completion of delivery. The tracking provides substantially a “24/7” access to the location and updated estimated completion of delivery. Upon completion of delivery, the tracking is terminated (automatic opt-out).

Abstract: A fluid-fillable cushion comprises upper and lower layers, a first chamber and a second chamber and a discrete pressure distributing unit situated between the upper and lower layers, said pressure distributing unit providing a fluid connection between at least the first chamber and the second chamber. Such a cushion reduces leaks and allows controlled pressure equalisation between the chambers. Also disclosed is a process for making such cushions and seating products comprising such cushions.

Abstract: A probe system for facilitating inspection of a device under test comprising a plurality of panels, the probe system incorporating: a configurable universal probe bar comprising a plurality of probe blocks, the plurality of probe blocks comprising a plurality of probe pins positioned to simultaneously electrically engage a plurality of cell contact pads of the plurality of panels of the device under test to deliver a plurality of electrical test signals; and an alignment system configured to achieve an alignment of the plurality of probe pins with the plurality of the cell contact pads of the plurality of panels of the device under test.

Abstract: Transportation services are matched with demand, in multiple segments in accordance with capabilities and business practices of a transportation service provider. A request for transportation services is received, including an origin, destination and a characterization of a load or service. Origin and destination geographical areas or locations are identified, and a main line segment and at least one distinct segment are identified to form a contiguous multi-segment routing. A transportation service provider is matched to the specified demand for transportation services, in order to comply with the scheduled sequence. One or more competitive bids are aggregated to provide a total bid price and provision of the transportation services are arranged using the candidate service interests winning the bid or bids.

Abstract: An adjustable recessed trim for a lighting fixture includes an enclosure with a light output opening and a light source opening provided upward from the light output opening. An adjustable cover piece having a cover piece light source opening is provided over the enclosure in registration with the enclosure light source opening and is adjustable between at least a first position and a second position.

Abstract: Transportation services are matched with a specified demand for transportation services. Categories of transportation services met by capabilities of the transportation service provider is determined, along with preference data concerning the transportation service provider. Candidate service interest is used to match the transportation service provider to the specified demand for transportation services. Competitive bids are obtained to meet a specified demand for transportation services, and the transportation service provider is offered inclusion in the competitive bids based on the candidate service interest. If the transportation service provider wins the bid, provision of the transportation service are arranged, and if the transportation service provider loses the bid, repeating the sequence of using the candidate service interest to match the transportation service provider to the specified demand for transportation services.