Abstract: The present invention provides a method of treating a cancer in a subject comprising administering to the subject an effective amount of a CD33-targeted antibody-drug conjugate (ADC) and an effective amount of a poly-ADP ribose polymerase (PARP) inhibitor. Also provided are pharmaceutical compositions comprising an effective amount of a CD33-targeted ADC and an effective amount of a PARP inhibitor.

Abstract: A device and method for shelling nuts. The device may be attached to a belt sander. The device includes a hopper into which the nuts are initially placed. Two large threaded fasteners on the central portion are used to adjust the system for the size of nut being shelled. A bracket placed behind the central portion attaches the device to the sander. The rotating belt brings the nut down to a lower opening formed to be just smaller than the shell of the nut being shelled. As the shell of the nut is caused to pass through this opening, the shell cracks. The nut with the cracked shell now impacts on one or more strike plates. These impacts further propagate the cracks formed in the shell so that the fragmented shells fall away from the nut. The nut and the cracked shells fall into the collection bag.

Abstract: A device and method for shelling nuts. The device may be attached to a belt sander. The device includes a hopper into which the nuts are initially placed. Two large threaded fasteners on the central portion are used to adjust the system for the size of nut being shelled. A bracket placed behind the central portion attaches the device to the sander. The rotating belt brings the nut down to a lower opening formed to be just smaller than the shell of the nut being shelled. As the shell of the nut is caused to pass through this opening, the shell cracks. The nut with the cracked shell now impacts on one or more strike plates. These impacts further propagate the cracks formed in the shell so that the fragmented shells fall away from the nut. The nut and the cracked shells fall into the collection bag.

Abstract: The system and method of the present invention includes three parts. Uppermost is a mesh tray on which to rest the food items being cooked. Under the mesh tray is a tray having openings formed therein. Under the tray with openings formed therein is a solid tray. Materials which emit a scent when heated which will permeate the food items being cooked are placed between the bottom of the tray with openings formed therein and the top of the solid tray.

Abstract: The disclosed invention includes a set of nested socket members, screw bits, an adaptor, and an elongated hollow handle with an array of additional accessories to improve the operability and utility of the basic tool.

Abstract: A computer based method, in a system wherein a plurality of predetermined users, each having a predetermined sales region and each having access to a secured portion of a main server, for enhancing each user's ability to rapidly respond to internet based inquiries regarding construction machinery and earth moving equipment, includes the steps of receiving, at an internet web site of the main server, a plurality of customer inquiries, the inquiries each including information about the customer, opening an inquiry file on each received, unanswered inquiry, each inquiry file including the customer information, and sorting each inquiry file into one of a plurality of predetermined regions corresponding to sales regions of the users, wherein the sorting is based upon the customer information.

Abstract: A safety shutter for use in ordnance fuzes and the like consisting of two more metal plates in contact, with each region of contact shaped so that the plates are touching, or nearly touching, only at isolated points or small regions over the confronting faces so that there are six spaces between and intermingled with the areas of contact of the plates such that the broken interfaces between the plates interrupt the transmission of a shock wave capable of inducing spalling from the surface of the shutter which faces the secondary explosive thereby preventing accidental initiation of a propagating detonation. The broken interfaces also absorb the energy of an inadvertently functioned detonator by local crushing and shearing of the metal protuberances on each of the confronting faces of the plates.