Patents by Inventor Rustem F. Ismagilov

Rustem F. Ismagilov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DEVICES AND METHODS FOR DIRECT VISUAL DETECTION AND READOUT OF SINGLE NUCLEIC ACID MOLECULES
    Publication number: 20180321137
    Abstract: The present invention relates to methods, computer readable medium and systems for detecting and counting single nucleic acid molecules confined in nanoliter volumes using an unmodified camera, such as a cell phone camera. In particular, it identifies colorimetric amplification-indicator dyes that are compatible with the spectral sensitivity of standard mobile phones. The invention further provides an optimal ratiometric image-process for a selected dye to achieve a readout that is robust to lighting conditions and camera hardware and provides unambiguous quantitative results, even for colorblind users.
    Type: Application
    Filed: November 4, 2016
    Publication date: November 8, 2018
    Inventors: Rustem F. ISMAGILOV, Jesus Rodriguez MANZANO, Mikhail KARYMOV, David A. SELCK, Stefano BEGOLO, Erik B. JUE, Dmitriy V. ZHUKOV
  • Device and method for pressure-driven plug transport and reaction
    Patent number: 10118174
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: November 6, 2018
    Assignee: The University of Chicago
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song Baca, Lewis Spencer Roach
  • Method for Conducting an Autocatalytic Reaction in Plugs in a Microfluidic System
    Publication number: 20180304268
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: March 20, 2018
    Publication date: October 25, 2018
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
  • Device and method for pressure-driven plug transport and reaction
    Patent number: 10105703
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: October 23, 2018
    Assignee: The University of Chicago
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song Baca, Lewis Spencer Roach
  • Device and method for pressure-driven plug transport and reaction
    Publication number: 20180272352
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: March 20, 2018
    Publication date: September 27, 2018
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
  • MICROFLUIDIC MEASUREMENTS OF THE RESPONSE OF AN ORGANISM TO A DRUG
    Publication number: 20180274020
    Abstract: Disclosed herein are methods and devices for rapid assessment of whether a microorganism present in a sample is susceptible or resistant to a treatment.
    Type: Application
    Filed: November 5, 2015
    Publication date: September 27, 2018
    Inventors: Rustem F. ISMAGILOV, Eugenia KHOROSHEVA, Travis S. SCHLAPPI, Matthew S. CURTIS, Nathan G. SCHOEPP, Hedia MAAMAR, Feng SHEN, Erik B. JUE
  • Method for Conducting Reactions Involving Biological Molecules in Plugs in a Microfluidic System
    Publication number: 20180272351
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: March 20, 2018
    Publication date: September 27, 2018
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
  • Methods for manipulating spacing between microdroplets flowing in a microfluidic system
    Patent number: 10054961
    Abstract: The present invention provides manipulation of spacing between microdroplets flowing in a microfluidic system. The manipulation includes increasing and/or decreasing spacing between a pair of adjacent droplets of a sample fluid flowing in an immiscible carrier fluid within a main microfluidic channel. The main microfluidic channel includes a region having one or more side branch channels. The spacing between the pair of droplets flowing through the region can be increased or reduced with either the addition of or removal of immiscible carrier fluid between the adjacent droplets via at least one of the side branch channels, wherein the pair of droplets remain intact while flowing through the region and continue to flow within the main microfluidic channel downstream of the region.
    Type: Grant
    Filed: February 19, 2014
    Date of Patent: August 21, 2018
    Assignee: The University of Chicago
    Inventors: Rustem F. Ismagilov, Bo Zheng, Cory John Gerdts
  • DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION
    Publication number: 20180193838
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: January 3, 2018
    Publication date: July 12, 2018
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song Baca, Lewis Spencer Roach
  • DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION
    Publication number: 20180193837
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: January 3, 2018
    Publication date: July 12, 2018
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song Baca, Lewis Spencer Roach
  • DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION
    Publication number: 20180154362
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: November 29, 2017
    Publication date: June 7, 2018
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song Baca, Lewis Spencer Roach
  • Device and method for pressure-driven plug transport and reaction
    Patent number: 9968933
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: May 15, 2018
    Assignee: The University of Chicago
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song Baca, Lewis Spencer Roach
  • DIGITAL QUANTIFICATION OF DNA REPLICATION AND/OR CHROMOSOME SEGREGATION BASED DETERMINATION OF ANTIMICROBIAL SUSCEPTIBILITY
    Publication number: 20180105859
    Abstract: Disclosed herein are methods and devices for using digital isothermal amplification to detect subtle responses to environmental stimuli, such as detecting antibiotic susceptibility using digital quantification of DNA replication and/or chromosome segregation.
    Type: Application
    Filed: September 25, 2017
    Publication date: April 19, 2018
    Inventors: Rustem F. Ismagilov, Nathan G. Schoepp, Travis S. Schlappi, Matthew S. Curtis
  • Device and method for pressure-driven plug transport and reaction
    Patent number: 9889446
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: February 13, 2018
    Assignee: The University of Chicago
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song Baca, Lewis Spencer Roach
  • DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION
    Publication number: 20170368551
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: August 10, 2017
    Publication date: December 28, 2017
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song Baca, Lewis Spencer Roach
  • MICROFLUIDIC SYSTEM
    Publication number: 20170364101
    Abstract: The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.
    Type: Application
    Filed: June 30, 2017
    Publication date: December 21, 2017
    Inventors: Rustem F. Ismagilov, Bo Zheng, Cory John Gerdts
  • DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION
    Publication number: 20170361321
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Application
    Filed: August 10, 2017
    Publication date: December 21, 2017
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song Baca, Lewis Spencer Roach
  • Device and method for pressure-driven plug transport and reaction
    Patent number: 9839893
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: December 12, 2017
    Assignee: The University of Chicago
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song, Lewis Spencer Roach
  • Fluidic devices and systems for sample preparation or autonomous analysis
    Patent number: 9822356
    Abstract: The present invention relates to fluidic devices for preparing, processing, storing, preserving, and/or analyzing samples. In particular, the devices and related systems and methods allow for preparing and/or analyzing samples (e.g., biospecimen samples) by using one or more of capture regions and/or automated analysis.
    Type: Grant
    Filed: April 22, 2013
    Date of Patent: November 21, 2017
    Assignees: California Institute of Technology, SlipChip Corporation
    Inventors: Rustem F. Ismagilov, Feng Shen, Liang Li, Yu-Hsiang Hsu, Stefano Begolo, Mikhail Karymov, David Selck, Stephanie McCalla, Philip James Homewood
  • Fluidic devices for biospecimen preservation
    Patent number: 9808798
    Abstract: The present invention relates to fluidic devices for preparing, processing, storing, preserving, and/or analyzing samples. In particular, the devices and related systems and methods allow for preservation or storage of samples (e.g., biospecimen samples) by using one or more of a bridge, a membrane, and/or a desiccant.
    Type: Grant
    Filed: April 22, 2013
    Date of Patent: November 7, 2017
    Assignee: California Institute of Technology
    Inventors: Rustem F. Ismagilov, Qichao Pan, Stefano Begolo